Publications by authors named "Gasparik J"

Article Synopsis
  • Streptomyces coelicolor is a bacterium found in soil that produces antibiotics, but nickel accumulation can hinder its ability to create one specific antibiotic, undecylprodigiosin.
  • The transcriptional repressor Nur, which regulates nickel uptake, has two metal-binding sites (M-site and Ni-site) that are crucial for its activity.
  • Research using mutational studies and metal binding analysis has revealed a model showing how binding of metals to Nur influences its ability to bind DNA and activate its functions, with findings suggesting that binding to the Ni-site reduces DNA affinity despite cooperative metal binding.
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Due to environmental pollution, wild animals are exposed to various pollutants. Some game animals, such as wild boars are used by people for food, but their meat is not evaluated regarding pollution transfer, since they are unavailable on the official market. The aim of this paper is to present the concentrations of chosen metals (Cd, Co, Cu, Hg, Pb, and Zn) in the kidneys, liver, and muscles of wild boars (n = 40) hunted in eastern Slovakia, as derivatives of physiological distribution and anthropogenic pollution.

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Lead poisoning has been reported in almost every country on earth. In this study the effect of experimental lead pellet intake (2-6 pellets per week [groups B2, B4, B6] and ad libitum [BAD] accessibility for 10 weeks) on its distribution in liver, kidney, pectoral muscle, ovary, eggs and the effect of selected reproductive parameters (egg weight, fertilization, hatchability) was analyzed in breeding pheasants. Lead pellets were force fed to the digestive tract (struma, ingluvies) and the ingestion was controlled.

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This study aimed at obtaining the data on the occurrence, levels and correlations of organic pollutants present in game animals (n = 75, Brown hare, Lepus europaeus Pall.) in the region of south-western Slovakia. The analyses performed included dichlorodiphenyltrichloroethane (DDT), hexachlorobenzen (HCB), alpha- and beta hexachlorocyclohexane (α+β-HCH), gamma-hexachlorocyclohexane (γ-HCH), and polychlorinated biphenyls (PCB-delor, commercial mixture of PCB congeners).

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The aim of this study was to monitor accumulation of cadmium (Cd), mercury (Hg), zinc (Zn), copper (Cu) and cobalt (Co) in the muscle, liver and kidney of wild boar (Sus scrofa scrofa) from hunting place of western Slovakia and the correlations among the observed elements. A total of 120 samples were involved for analyses by atomic absorption spectrophotometry (AAS). The significantly highest accumulation of Cd in the kidney followed by the liver and muscles was found.

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The aim of this study was to monitor accumulation of lead, cadmium, mercury and arsenic in leg skeletal muscle of some wild birds from selected areas of Slovakia and the correlations among the heavy metals. A total of 160 wild birds representing 3 species-Eurasian coot (Fulica atra) (n = 24), mallard (Anas platyrhynchos) (n = 68) and pheasant (Phasianus colchicus) (n = 68) were involved for analyses. Concentrations of heavy metals from samples were measured using atomic absorption spectrophotometry (AAS).

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The content of cadmium and lead, as risk factors of environment, in liver and kidneys of wild animals as brown hare (Lepus europaeus), yellow-necked mouse (Apodemus flavicollis), wood mouse (Cleithrionomys glareolus), and red deer (Cervus elaphus) were studied. Samples were analyzed by the atomic absorption spectrophotometry method (AAS). The highest levels of cadmium were found in kidneys (0.

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Concentration of cadmium, lead, chromium, zinc, copper, and manganese in liver, kidney, and muscle of red deer was investigated. For analysis of the content of these trace elements an AAS method was used. The concentration of cadmium was significantly (p < 0.

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Investigations of the conformation of endogenous enkephalins are generally based on structural comparisons of enkephalins with other opiates and on experimental pharmacological studies. Based on such investigations, we now propose a novel model of the biologically active (receptor-bound) conformation of [Met5]- and [Leu5]enkephalin on the delta opioid receptor. The model helps with the design of new opioid analgesics.

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