Publications by authors named "Gaspard Lens"
BMJ Open Gastroenterol
July 2020
Article Synopsis
- Oesophageal cancer (OEC) has a low survival rate, highlighting the need for effective prognostic markers, particularly the histopathological growth pattern (HGP) as a potential indicator.
- A study analyzed HGP in two cohorts: one from The Cancer Genome Atlas with 89 untreated patients and another with 99 treated patients from Belgium, by evaluating H&E stained images and gene expression data.
- Results showed that patients with infiltrative growth patterns (IGP) had worse outcomes and were linked to more aggressive tumor features, while pathways like angiogenesis, epithelial-to-mesenchymal transition, and inflammation were significantly activated in IGP samples compared to expansive growth patterns (EGP).
