Publications by authors named "Gary D Uy"
Article Synopsis
- The extra-embryonic endoderm lineage is crucial for supporting embryo nutrition and plays key roles in development, such as forming blood islands.
- Blastocyst-derived embryonic stem (ES) and trophoblast stem (TS) cell lines are well-established models, prompting the study of the less-explored extra-embryonic endoderm (XEN) lineage through newly derived cell lines.
- XEN cell lines from mouse blastocysts maintain their characteristics without aging signs, show specific endoderm markers, and exhibit unique X chromosome inactivation patterns, confirming their potential as a model for studying early mammalian development.
At the blastocyst stage of pre-implantation mouse development, close contact of polar trophectoderm with the inner cell mass (ICM) promotes proliferation of undifferentiated diploid trophoblast. However, ICM/polar trophectoderm intimacy is not maintained during post-implantation development, raising the question of how growth of undifferentiated trophoblast is controlled during this time. The search for the cellular basis of trophoblast proliferation in post-implantation development was addressed with an in vitro spatial and temporal analysis of fibroblast growth factor 4-dependent trophoblast stem cell potential.
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