Claudin-3 and claudin-4 expression in serous papillary, clear-cell, and endometrioid endometrial cancer.

Objective: Tight junction (TJ) proteins claudin-3 and claudin-4 may be differentially expressed in uterine serous papillary carcinoma (USPC), a rare form of endometrial cancer characterized by a particularly poor prognosis. Our aim was to determine the expression pattern and prognostic relevance of claudin-3 and claudin-4 in a large cohort of endometrial cancer patients of diverse histological type and stage.

Methods: Claudin-3 and claudin-4 expression was studied in a cohort of 287 patients with endometrial cancer including 137 cases of USPC or clear-cell histology using immunohistochemistry.

Role of systematic lymphadenectomy and adjuvant therapy in stage I uterine papillary serous carcinoma.

Objective: To assess surgical staging with systematic lymphadenectomy (LND) and adjuvant therapy in patients with stage I uterine papillary serous carcinoma (UPSC).

Methods: A single-institution, retrospective review was conducted of all surgically treated patients with primary UPSC between 1982 and 2005.

Results: 42 patients (IA=15, IB=21, IC=6) were stage I.