Publications by authors named "Garvin Dodard"
EOMES and T-BET are related T-box transcription factors that control natural killer (NK) cell development. Here we demonstrate that EOMES and T-BET regulate largely distinct gene sets during this process. EOMES is dominantly expressed in immature NK cells and drives early lineage specification by inducing hallmark receptors and functions.
View Article and Find Full Text PDFArticle Synopsis
- Checkpoint blockade therapy is a promising cancer treatment, but not all patients benefit, highlighting the need for new targets.
- Blocking the KLRG1 receptor improves anti-tumor responses from NK cells and CD8 T cells, significantly reducing melanoma and breast cancer growth in mice.
- Combining KLRG1 blockade with PD-1 therapy enhances treatment effectiveness, leading to reduced tumor size and increased immune cell activation, even in tumors resistant to PD-1 therapy.
The liver harbors two main innate lymphoid cell (ILC) populations: conventional NK (cNK) cells and tissue-resident NK (trNK) cells. Using the MCMV model of infection, we find that, in contrast to liver cNK cells, trNK cells initially undergo a contraction phase followed by a recovery phase to homeostatic levels. The contraction is MCMV independent because a similar phenotype is observed following poly(I:C)/CpG or α-GalCer injection.
View Article and Find Full Text PDF