Publications by authors named "Garry M Dolton"
Article Synopsis
- - In type 1 diabetes, CD8+ T cells that target insulin-producing β cells in the pancreas are involved in the destruction of these cells, but the role of similar T cells found in the blood is not well understood.
- - A study tracked different circulating β cell-reactive CD8+ T cell subsets and β cell function for 2 years post-diagnosis, finding a positive correlation between certain T cells (CD57+ memory T cells) and insulin levels in kids under 12.
- - The research suggests that changes in these specific T cells can reflect the body's ability to produce insulin, indicating their potential use for monitoring the immune response and as a target for future treatments in type 1 diabetes.
Altered peptide antigens that enhance T-cell immunogenicity have been used to improve peptide-based vaccination for a range of diseases. Although this strategy can prime T-cell responses of greater magnitude, the efficacy of constituent T-cell clonotypes within the primed population can be poor. To overcome this limitation, we isolated a CD8(+) T-cell clone (MEL5) with an enhanced ability to recognize the HLA A*0201-Melan A(27-35) (HLA A*0201-AAGIGILTV) antigen expressed on the surface of malignant melanoma cells.
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