Publications by authors named "Garrett W Fisher"
Article Synopsis
- The study focuses on tissue engineering aimed at repairing the small bowel using human intestinal organoids (HIOs) created from human pluripotent stem cells.
- Researchers tested the ability of these organoids to engraft and aid healing in a rodent model with acute bowel damage, showing they can proliferate and integrate into various layers of the intestine.
- Key results included the restoration of the mucosal layer, integration into muscle and blood vessel tissues, and the long-term presence of diverse cell types, highlighting the role of mesenchyme in effective intestinal repair.
Rosacea pathogenesis and therapeutics: current treatments and a look at future targets.
Front Med (Lausanne)
December 2023
Rosacea is a chronic inflammatory skin condition associated with a significant health and economic burden from costs and loss of productivity due to seeking medical treatment. The disease encompasses multiple phenotypic manifestations involving a complex and multi-variate pathogenesis. Although the pathophysiology of rosacea is not completely understood, ongoing research is continually elucidating its mechanisms.
View Article and Find Full Text PDFThe in vitro differentiation of pluripotent stem cells into human intestinal organoids (HIOs) has served as a powerful means for creating complex three-dimensional intestinal structures. Owing to their diverse cell populations, transplantation into an animal host is supported with this system and allows the temporal formation of fully laminated structures, including crypt-villus architecture and smooth muscle layers that resemble native human intestine. Although the endpoint of HIO engraftment has been well described, here we aim to elucidate the developmental stages of HIO engraftment and establish whether it parallels fetal human intestinal development.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers developed a method to incorporate human immune cells into HIOs by transplanting them into mice with a humanized immune system, enabling the study of immune interactions.
- * The study found that human immune cells migrate to the HIOs and respond to microbial exposure, activating the immune response and providing a new model for researching intestinal diseases.