Surgeon Energy Expenditure and Substrate Utilization During Simulated Spine Surgery.

Introduction: Orthopaedic surgery can be a physically demanding occupation with high rates of fatigue and burnout. Fatigue has been shown to affect surgeon performance with higher rates of errors in fatigued surgeons. The metabolic cost of performing surgery has yet to be quantified.

Cartilage Metabolism is Modulated by Synovial Fluid Through Metalloproteinase Activity.

Synovial fluid (SF) contains various cytokines that regulate chondrocyte metabolism and is dynamically associated with joint disease. The objective of this study was to investigate the effects of diluted normal SF on catabolic metabolism of articular cartilage under inflammatory conditions. For this purpose, SF was isolated from healthy bovine joints, diluted, and added to cartilage explant cultures stimulated with interleukin-1 (IL-1) for 12 days.

Liver transplantation with a strongly positive crossmatch: case study and literature review.

A positive crossmatch has been associated with increased risk in liver transplantation. To study the clinical significance of preformed donor-specific human leukocyte antigen antibodies (DSAs) in liver transplantation, we reviewed patients who underwent liver transplantation with a strongly positive flow cytometry crossmatch. DSAs were evaluated with a Luminex solid phase assay.

Total knee arthroplasty in patients with a left ventricular assist device.

Many patients with severe cardiac disease can now live for a prolonged period with left ventricular assist devices (LVADs), and some patients will develop noncardiac medical issues that may benefit from surgical intervention. Previous studies have reported a low rate of complications in patients with LVADs undergoing noncardiac surgical procedures. We report the cases of 2 patients with LVADs who underwent total knee arthroplasties for osteoarthritis.

Outcomes of total hip and knee arthroplasty after cardiac transplantation.

The outcomes of 18 primary or revision total hip (THA) and knee arthroplasties (TKA) in 9 patients with cardiac transplants were reviewed. Primary total joint arthroplasties were performed for osteonecrosis (5 hips) or osteoarthritis (5 hips, 4 knees). There were no infections in any of these patients.