Right Atrium Primary Cardiac Lymphoma Causing Heart Failure.

 Patients with primary cardiac tumors may present with symptoms based on the size and location of the tumor. Symptoms may include congestive heart failure secondary to intracardiac obstruction, systemic embolization, arrhythmias, and constitutional symptoms.  A patient presented with new onset atrial fibrillation and heart failure.

Identification of genomic alterations with clinical impact in canine splenic hemangiosarcoma.

Canine hemangiosarcoma (HSA) is an aggressive cancer of endothelial cells with short survival times. Understanding the genomic landscape of HSA may aid in developing therapeutic strategies for dogs and may also inform therapies for the rare and aggressive human cancer angiosarcoma. The objectives of this study were to build a framework for leveraging real-world genomic and clinical data that could provide the foundation for precision medicine in veterinary oncology, and to determine the relationships between genomic and clinical features in canine splenic HSA.

Shared hotspot mutations in oncogenes position dogs as an unparalleled comparative model for precision therapeutics.

Naturally occurring canine cancers have remarkable similarities to their human counterparts. To better understand these similarities, we investigated 671 client-owned dogs from 96 breeds with 23 common tumor types, including those whose mutation profile are unknown (anal sac carcinoma and neuroendocrine carcinoma) or understudied (thyroid carcinoma, soft tissue sarcoma and hepatocellular carcinoma). We discovered mutations in 50 well-established oncogenes and tumor suppressors, and compared them to those reported in human cancers.

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogs.

Spontaneous tumors in canines share significant genetic and histological similarities with human tumors, positioning them as valuable models to guide drug development. However, current translational studies have limited real world evidence as cancer outcomes are dispersed across veterinary clinics and genomic tests are rarely performed on dogs. In this study, we aim to expand the value of canine models by systematically characterizing genetic mutations in tumors and their response to targeted treatments.

Midterm outcomes of 455 patients receiving the AFX2 endovascular graft for the treatment of abdominal aortic aneurysm: A retrospective multi-center analysis.

Since being introduced into clinical practice the AFX family of endografts has undergone labelling updates, design and manufacturing changes to address a Type III failure mode. The published literature on the performance of the current endograft-AFX2 -is limited to small series with limited follow up. The present study reports the largest series of patients implanted with AFX2 for the treatment of abdominal aortic aneurysms.

Risk stratification and prognostic effects of internal thoracic artery grafting during acute myocardial infarction.

Objective: Surgeons are occasionally requested to perform coronary artery bypass grafting during acute myocardial infarction. We intended to test the safety of coronary artery bypass grafting and internal thoracic artery grafting early after myocardial infarction using the Society of Thoracic Surgeons database.

Methods: The database was queried for isolated coronary artery bypass grafting less than 24 hours after a myocardial infarction from 2002 to 2008.

A short history of the Society of Thoracic Surgeons national cardiac database: perceptions of a practicing surgeon.

The Society of Thoracic Surgeons database was developed as an initiative to standardize nationwide outcomes in adult cardiac surgery, and it has currently expanded into general thoracic and congenital cardiac surgery databases. For more than 19 years since its inception, the Society of Thoracic Surgeons database has grown as a powerful source of risk-adjusted outcomes, large scale scientific contributions, and invaluable information for healthcare policy making. This review article provides a snapshot of the genesis, history, growth, and scientific contributions of the Society of Thoracic Surgeons database to stimulate the participation of thoracic surgery programs and maximize its future use for investigational purposes.

An unusual presentation of spontaneous pneumothorax secondary to talc-induced pulmonary granulomatosis.

Talc-induced pulmonary granulomatosis is an unusual condition resulting from the intravenous administration of medications intended for oral use. A patient with this condition who presented with a spontaneous tension pneumothorax is reported. Although the radiographic findings of a diffuse reticulonodular pattern are typical, this patient was found to have diffuse, small cavitary pulmonary nodules.

Management of acute infrarenal aortic occlusion secondary to type A dissection.

Infrarenal aortic occlusion is a well described complication of type A aortic dissection that carries a significant mortality rate. A technique of immediate reperfusion of the lower extremities through an axillo-bi-femoral graft is described in 2 patients with good results.