Publications by authors named "Garrett Garbo"
Article Synopsis
- * Most patients started DRSP-C for conditions like dysmenorrhea (58.8%) or endometriosis (44.8%), and around 84.6% reported improvement in their pelvic pain or dysmenorrhea after starting the treatment.
- * While 41.3% experienced breakthrough bleeding, only a small number (42%) of those affected chose to discontinue the medication, indicating that DRSP-C is generally well tolerated and effective for managing menstrual issues in adolescents.
Use of the Drospirenone-Only Contraceptive Pill in Adolescents with Endometriosis.
J Pediatr Adolesc Gynecol
August 2024
Study Objective: To evaluate the efficacy and tolerability of a progestin-only pill containing 4 mg drospirenone (DRSP) as a hormonal therapy for the management of endometriosis-associated symptoms in adolescents and young adults.
Design: Retrospective cohort study.
Methods: A retrospective chart review was performed of all adolescents who were prescribed DRSP continuously (without placebo) for treatment of endometriosis at a single pediatric tertiary care center between 2019 and 2022.
Article Synopsis
- Recent studies have linked a genetic risk for type 2 diabetes with a lower likelihood of accumulating body fat, paralleling traits seen in metabolically obese normal weight (MONW) individuals.
- Researchers identified a specific genetic variant (rs6712203) in the COBLL1 gene that influences gene expression and affects how fat cells grow and store lipids, leading to difficulties in developing proper adipose tissue.
- Using mouse models, they demonstrated that altering the COBLL1 gene mirrors MONW traits, including reduced body fat and impaired glucose regulation, highlighting a potential target for future diabetes treatments and understanding of genetic influences on metabolism.