Publications by authors named "Garret Williford"
Article Synopsis
- Glioblastoma is the most common and aggressive brain tumor in adults, with a survival rate of less than 2 years and very low rates of extraneural metastasis.
- A unique case is presented where extensive metastasis occurred outside the brain, diagnosed through next-generation sequencing (NGS) rather than traditional histology.
- The molecular analysis revealed key alterations shared between the original tumor and the metastatic sites, highlighting the critical role of NGS in identifying and understanding rare cases of extraneural glioblastoma metastasis.
Background: Reports suggest that phosphatidylinositol 3-kinase pathway alterations confer increased risk of progression and poor prognosis in oligodendroglioma, IDH-mutant, and 1p/19q-codeleted molecular oligodendrogliomas (mODG). However, factors that affect prognosis in mODG have not been thoroughly studied. In addition, the benefits of adjuvant radiation and temozolomide (TMZ) in mODGs remain to be determined.
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