Efficient Biochemical Method for Characterizing and Classifying Related Amyloidogenic Peptides.

Amyloidosis is a group of proteinopathies characterized by the systemic or organ-specific deposition of proteins in the form of amyloid fibers. Nearly 40 proteins play a role in these pathologies, and the structures of the associated fibers are beginning to be determined by Cryo-EM. However, the molecular events underlying the process, such as fiber nucleation and elongation, are poorly understood, which impairs developing efficient therapies.

Dynamics of Cu and Pb during sediment remobilization and associated risk for coastal water quality.

Laboratory resuspension experiments were performed using three sediments and seawater, contrasted in terms of metals concentration/contents, metals partitioning in sediments as well as physical-chemical characteristics of both sediment and seawater. The aim of the study was to examine if the variability in metals content and metals distribution onto carrier phases are influencing the dynamics of metal transfers from and to sediment. Since Cu and Pb are classical contaminants found in coastal areas, their dissolved concentrations were monitored (up to 360 h) to assess their release or removal by particles, with a particle concentration of 2.

Preparation of superabsorbent composite(s) based on dialdehyde cellulose extracted from banana fiber waste.

The study focus is the valorization of banana agriculture by products by the extraction and derivatization of cellulose and its incorporation in formulations to produce superabsorbent materials endowed with high water absorption performances. The extracted cellulose (BP) was subjected to a controlled oxidation by sodium periodate to convert it to cellulose dialdehyde (DAC) with controlled aldehyde content. The cellulosic materials were incorporated into a suspension containing acrylic acid (AA) and itaconic acid (IA) to produce composite hybrid hydrogels (SA-BP/SA-DAC) by radical chain polymerization in water, using N,N-methylene-bis-acrylamide (MBA) as a cross-linking agent and potassium persulfate (KPS) as an initiator.

Sources, chronology of deposition, and mobility of mercury and methylmercury in the sediments of a contaminated Mediterranean bay.

Coastal sediments constitute a major reservoir for natural and anthropogenic mercury (Hg) and can be used as geochronological records of past Hg deposition. They may also act as secondary Hg sources for pelagic ecosystems via the efflux of toxic methylmercury (MeHg) diffusing from sediment porewaters and/or mobilized by sediment resuspension. In Toulon Bay sediments, which are known as one of the Hg hot spots of the northwestern Mediterranean Sea, we explored Hg species accumulation and mobility.

Making Rift Valley Fever Viral Particles Fluorescent.

Rift Valley fever virus (RVFV) is a mosquito-borne pathogen that represents a significant threat to both human and veterinary public health. Since its discovery in the Great Rift Valley of Kenya in the 1930s, the virus has spread across Africa and beyond, now posing a risk of introduction into Southern Europe and Asia. Despite recent progresses, early RVFV-host cell interactions remain largely uncharacterized.

Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022.

Introduction: In recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to further characterize patterns of pregabalin users from substance abuse treatment facilities and detect changes in users profile over the study period.

Methods: The data source was the Observation des Produits Psychotropes Illicites ou Détournés de leur Utilisation Médicamenteuse (OPPIDUM) program, an annual, repeated, cross-sectional, nationwide, multicenter survey that collects consumption data from patients with substance use disorders.

One-Step Selective Labeling of Native Cell Surface Sialoglycans by Exogenous α2,8-Sialylation.

Exo-enzymatic glycan labeling strategies have emerged as versatile tools for efficient and selective installation of terminal glyco-motifs onto live cell surfaces. Through employing specific enzymes and nucleotide-sugar probes, cells can be equipped with defined glyco-epitopes for modulating cell function or selective visualization and enrichment of glycoconjugates. Here, we identifysialyltransferase Cst-II I53S as a tool for cell surface glycan modification, expanding the exo-enzymatic labeling toolkit to include installation of α2,8-disialyl epitopes.

Polyaryletherketone Based Blends: A Review.

This review aims to report the status of the research on polyaryletherketone-based thermoplastic blends (PAEK). PAEK are high-performance copolymers able to replace metals in many applications including those related to the environmental and energy transition. PAEK lead to the extension of high-performance multifunctional materials to target embedded electronics, robotics, aerospace, medical devices and prostheses.

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Objective: New genome sequencing techniques allow new approaches in medical genetics, in particular by facilitating the diagnosis of genetic diseases. However, their use also leads to unsolicited genetic findings being uncovered. This type of discovery raises ethical, legal and psychological considerations.

Extreme hydrological regimes of a small urban river: impact on trace element partitioning, enrichment and fluxes.

The input of trace elements from a small urban river (Las River, Toulon, France) located on the northern Mediterranean coast was studied during both base flow and flood events. A 2-year monitoring period of water flow and suspended particulate matter (SPM) showed a typical Mediterranean hydrological regime: a strong increase in water flow and SPM during short flood periods. During the flood event, an up to 2-fold increase in dissolved trace element (D) concentrations and particulate trace element content in SPM (P) was observed compared to the baseline discharge.

A CT-Based Clinical, Radiological and Radiomic Machine Learning Model for Predicting Malignancy of Solid Renal Tumors (UroCCR-75).

Background: Differentiating benign from malignant renal tumors is important for patient management, and it may be improved by quantitative CT features analysis including radiomic.

Purpose: This study aimed to compare performances of machine learning models using bio-clinical, conventional radiologic and 3D-radiomic features for the differentiation of benign and malignant solid renal tumors using pre-operative multiphasic contrast-enhanced CT examinations.

Materials And Methods: A unicentric retrospective analysis of prospectively acquired data from a national kidney cancer database was conducted between January 2016 and December 2020.

A bicellular fluorescent ductal carcinoma (DCIS)-like tumoroid to study the progression of carcinoma: practical approaches and optimization.

Recently, many types of 3D culture systems have been developed to preserve the physicochemical environment and biological characteristics of the original tumors better than the conventional 2D monolayer culture system. There are various types of models belonging to this culture, such as the culture based on non-adherent and/or scaffold-free matrices to form the tumors. Agarose mold has been widely used to facilitate tissue spheroid assembly, as it is essentially non-biodegradable, bio-inert, biocompatible, low-cost, and low-attachment material that can promote cell spheroidization.

Contamination of planktonic food webs in the Mediterranean Sea: Setting the frame for the MERITE-HIPPOCAMPE oceanographic cruise (spring 2019).

This paper looks at experiential feedback and the technical and scientific challenges tied to the MERITE-HIPPOCAMPE cruise that took place in the Mediterranean Sea in spring 2019. This cruise proposes an innovative approach to investigate the accumulation and transfer of inorganic and organic contaminants within the planktonic food webs. We present detailed information on how the cruise worked, including 1) the cruise track and sampling stations, 2) the overall strategy, based mainly on the collection of plankton, suspended particles and water at the deep chlorophyll maximum, and the separation of these particles and planktonic organisms into various size fractions, as well as the collection of atmospheric deposition, 3) the operations performed and material used at each station, and 4) the sequence of operations and main parameters analysed.

A new boronate ester-based crosslinking strategy allows the design of nonswelling and long-term stable dynamic covalent hydrogels.

Dynamic hydrogels are viscoelastic materials that can be designed to be self-healing, malleable, and injectable, making them particularly interesting for a variety of biomedical applications. To design dynamic hydrogels, dynamic covalent crosslinking reactions are attracting increasing attention. However, dynamic covalent hydrogels tend to swell, and often lack stability.

Early developmental toxicity of Atlantic salmon exposed to conventional and unconventional oils.

Atlantic salmon is an important species for Canadian culture and economy and its importance extends beyond Canada to Scandinavia and Western Europe. However, it is a vulnerable species facing decline due to habitat contamination and destruction. Existing and new Canadian pipeline projects pose a threat to salmonid habitat.

Assembling of Carbon Fibre/PEEK Composites: Comparison of Ultrasonic, Induction, and Transmission Laser Welding.

In the present work, an ultrasonic, an induction, and a through transmission laser welding were compared to join carbon fibre reinforced polyetheretherketone (CF/PEEK) composites. The advantages and drawbacks of each process are discussed, as well as the material properties required to fit each process. CF/PEEK plates were consolidated at 395 °C with an unidirectional sequence and cross-stacking ply orientation.

Peacefull: A French mindfulness-based intervention for adolescents with chronic pain a feasibility study.

Introduction: Pediatric chronic pain can lead to serious consequences in terms of daily functioning and global quality of life. Mindfulness-based intervention (MBI) approaches that emphasize accepting rather than controlling pain have gained increasing attention in adults with chronic pain. The effectiveness of MBIs for chronic pain in the pediatric population remains unknown.

Evaluation of Fatigue Life of Recycled Opaque PET from Household Milk Bottle Wastes.

Polyethylene terephthalate (PET) is among the most used thermoplastic polymers in large scale manufacturing. Opaque PET is increasingly used in milk bottles to save weight and to bring a glossy white aspect due to TiO nanoparticles. The recyclability of opaque PET is an issue: whereas the recycling channels are well established for transparent PET, the presence of opaque PET in household wastes weakens those channels: opaque bottles cannot be mixed with transparent ones because the resulting blend is not transparent anymore.

Rotavirus meningitis in an adult with transient aphasia.

We identified an additional case of documented Rotavirus meningitis in an adult with full medical history. A previously healthy 37-year-old patient presented herself for transient aphasia associated with fever and headaches at the end of a one-week history of gastroenteritis. Cerebrospinal fluid (CSF) analysis revealed lymphocytic meningitis, and treatment with aciclovir was initiated.

Separation of planar chiral ferrocenes by capillary electrokinetic chromatography and liquid chromatography.

Capillary electrokinetic chromatography (CEKC) and liquid chromatography (LC) methods were explored for the enantiomeric separation of six unsymmetrically disubstituted ferrocene derivatives. In normal-phase mode liquid chromatography, the use of n-heptane, ethanol or isopropanol with 1% n-butylamine as mobile phase on six polysaccharide-based columns, allowed to fully separate the enantiomers of three compounds out of the six (i.e 7-chloro-N-(2-((dimethylamino)methyl)ferrocenyl)quinolin-4-amine (ferroquine) (compound 1), 1-[(1S)-(1-Aminoethyl)]-2-(diphenylphosphino)ferrocene (compound 5) and 1-[(1R)-1-(Dicyclohexylphosphino)ethyl]-2-(diphenylphosphino)ferrocene (compound 6).

Cd transfers during marine sediment resuspension over short and long-term period: Associated risk for coastal water quality.

Cadmium (Cd) is a highly toxic metal, regularly monitored uniformly for water quality across Europe, but scarcely for sediments. This study was designed to compare the kinetics of Cd remobilization and the amplitude of its transfers with different marine sediments. The results showed a highly reproducible transfer kinetics.