Carnosinase inhibition enhances reactive species scavenging in high fat diet.

Aims: Life expectancy is typically reduced by 2-4 years in people with a body mass index (BMI) of 30-35 kg/m and by 8-10 years in people with a BMI of 40-50 kg/m. Obesity is also associated with onset, or exacerbation of, multiple chronic diseases. Mechanistically, this, in part, involves formation of advanced glycation and lipidation end-products that directly bond with proteins, lipids, or DNA, thereby perturbing typical cellular function.

Navigating Nature's Terrain: Jumping Performance Robust to Substrate Moisture and Roughness by Blackspotted Rockskippers (Entomacrodus striatus).

Escape responses are vital for the survival of prey. The high speeds and accelerations needed to evade predators successfully require exerting forces on the environment. Unlike water, terrestrial habitats can vary in ways that constrain the forces applied, requiring animals to adjust their behavior in response to variable conditions.

Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E Activity in Cancer.

Dysregulation of translation is a hallmark of cancer that enables rapid changes in cellular protein production to shape oncogenic phenotypes. Translation initiation is governed by the mGpppX cap-binding protein eukaryotic translation initiation factor 4E (eIF4E), the rate-limiting factor of cap-dependent translation initiation. eIF4E is overexpressed in many cancers and drives the production of oncoproteins that promote tumor growth and survival.

Novel mTORC2/HSPB4 Interaction: Role and Regulation of HSPB4 T148 Phosphorylation.

HSPB4 and HSPB5 (α-crystallins) have shown increasing promise as neuroprotective agents, demonstrating several anti-apoptotic and protective roles in disorders such as multiple sclerosis and diabetic retinopathy. HSPs are highly regulated by post-translational modification, including deamidation, glycosylation, and phosphorylation. Among them, T148 phosphorylation has been shown to regulate the structural and functional characteristics of HSPB4 and underlie, in part, its neuroprotective capacity.

A coaxial solid state nonlinear pulse forming line with an exponentially tapered ferrite composite core.

The need to optimize size, weight, and power of high-power microwave (HPM) systems has motivated the development of solid-state HPM sources, such as nonlinear transmission lines (NLTLs), which utilize gyromagnetic precession or dispersion to generate RF. One recent development implemented the NLTL as a pulse forming line (PFL) to form a nonlinear pulse forming line (NPFL) system that substantially reduced the system's size by eliminating the need for a separate PFL; however, matching standard loads can be challenging. This paper describes the development of a tapered NPFL using an exponentially tapered composite based ferrite core containing 60% nickel zinc ferrite (by volume) encased in polydimethylsiloxane (PDMS) and encapsulated in a 5% barium strontium titanate shell.

Risk Factors for Consensual and Coercive Sexual Hookup Behaviors among College Men: A Daily Diary Study.

Objective: Hookup behaviors (HUBs; i.e., sexual activity outside an exclusive relationship with no mutual expectation of romantic commitment) are prevalent on college campuses and are linked with alcohol use and sexual assault.

Polychlorinated biphenyl (PCB) concentrations and breakpoint trends across the waters of the Great Lakes by isotope-dilution high-resolution mass spectroscopy.

Water samples were collected during each of the 2012-2019 Cooperative Science and Monitoring Initiative (CSMI) cruises aboard the U.S. EPA R/V Lake Guardian as part of the Great Lakes Fish Monitoring and Surveillance Program (GLFMSP) lower food web contaminant assessment.

Cost-effectiveness of TAVI in the United Kingdom: a long-term analysis based on 4-year data from the Evolut Low Risk Trial.

Background: The cost-effectiveness of transcatheter aortic valve implantation (TAVI) vs. surgical aortic valve replacement (SAVR) has previously been reported across the spectrum of surgical mortality risk. We present an updated analysis specific to the UK based on 4-year data from the Evolut Low Risk Trial, which showed a maintained numerical survival benefit with TAVI.

Perceived Access to HIV Prevention Services Amidst the COVID-19 Pandemic Among Men Who Have Sex with Men (MSM) and MSM Sex Workers in France, Russia, and Türkiye.

This study examined the association between self-identification as a sex worker (SW) and perceived access to pharmacologic and non-pharmacologic HIV prevention methods among MSM in France, Russia, and Türkiye amidst the COVID-19 pandemic. Globally, 17,250 MSM recruited through a geosocial networking smartphone application completed the COVID-19 disparities survey, which was administered between October and November 2020. Approximately 38% of survey respondents were identified as living in France (n = 1269), Russia (n = 3882), and Türkiye (n = 3141) at the time of survey completion.

Polyethylene wear in metal-backed tibial components in unicompartmental knee prostheses.

The utilization of unicompartmental knee arthroplasty (UKA) has increased worldwide and has become a favourable alternative to total knee arthroplasty (TKA) in patients with isolated single-compartment knee osteoarthritis. With the increase in UKA utilization, there has been an increase in the number of revisions. The two most common causes of revision are the progression of osteoarthritis in other compartments and aseptic loosening with polyethylene wear, with other common causes for revision including periprosthetic fracture, bearing dislocation, infection, instability and unexplained pain.

College Students' Coercive Sexting and Intimate Partner Violence Perpetration in Shorter- and Longer-Term Relationships.

This study examines the moderating role of relationship length on the association between coercive sexting and intimate partner violence (IPV) perpetration. Research has supported a positive association between coercive sexting and IPV perpetration (Drouin et al., 2015), though no prior research has examined how relationship length moderates this association.

Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E (eIF4E) Activity in Drug-Resistant Melanoma.

Melanoma is the deadliest form of skin cancer with a 5-year survival rate of less than 20%. While significant strides have been made in the field of kinase-targeted and immune-based therapies for melanoma, the development of resistance to these therapeutic agents has hindered the success of treatment. Drug-resistant melanoma is particularly reliant on enhanced cap-dependent translation to drive the production of oncoproteins that promote growth and survival.

Effect of case identification changes on pre-hospital intubation performance indicators in an Australian helicopter emergency medical service.

Objective: A 45-min interval from injury to intubation has been proposed as a performance indicator for severe trauma patient management. In the Sydney pre-hospital system a previous change in case identification systems was associated with activation delay. We aimed to determine if this also decreased the proportion of patients intubated within this benchmark.

Maps of Membrane Pore Dynamics From Picosecond to Millisecond Pulse Durations.

Electroporation occurs when cells are exposed to an electric pulse of sufficient intensity and pulse duration . Many studies have attempted to develop universal scaling laws to predict membrane pore dynamics for pulsed electric fields (PEFs) of different durations; however, the differences in pore dynamics across these parameters makes this difficult both experimentally and numerically. This study uses the asymptotic Smoluchowski equation (ASME) to quantify the number of pores, average pore radius, and fractional pore area (FPA) during exposure to PEFs with durations from hundreds of picoseconds to a millisecond.

Feedback inhibition by a descending GABAergic neuron regulates timing of escape behavior in larvae.

Escape behaviors help animals avoid harm from predators and other threats in the environment. Successful escape relies on integrating information from multiple stimulus modalities (of external or internal origin) to compute trajectories toward safe locations, choose between actions that satisfy competing motivations, and execute other strategies that ensure survival. To this end, escape behaviors must be adaptive.

MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction.

Tissue fibrosis remains unamenable to meaningful therapeutic interventions and is the primary cause of chronic graft failure after organ transplantation. Eukaryotic translation initiation factor (eIF4E), a key translational regulator, serves as convergent target of multiple upstream profibrotic signaling pathways that contribute to mesenchymal cell (MC) activation. Here, we investigate the role of MAP kinase-interacting serine/threonine kinase-induced (MNK-induced) direct phosphorylation of eIF4E at serine 209 (Ser209) in maintaining fibrotic transformation of MCs and determine the contribution of the MNK/eIF4E pathway to the pathogenesis of chronic lung allograft dysfunction (CLAD).

Norovirus NS1/2 protein increases glutaminolysis for efficient viral replication.

Viruses are obligate intracellular parasites that rely on host cell metabolism for successful replication. Thus, viruses rewire host cell pathways involved in central carbon metabolism to increase the availability of building blocks for successful propagation. However, the underlying mechanisms of virus-induced alterations to host metabolism are largely unknown.

Adverse childhood experiences, posttraumatic stress disorder symptoms, and compulsive behaviors among adults in substance use treatment: A latent class analysis.

Adverse childhood experiences (ACEs) are prevalent and associated with common problems among adults with substance use disorders (SUDs), including posttraumatic stress disorder (PTSD) symptoms and compulsive behaviors. Most studies consider cumulative ACEs when examining their associations with health and behavioral outcomes. We tested whether patterns of ACEs related to SUD symptoms, PTSD symptoms, and compulsive behaviors among adults receiving treatment for substance use.

Nationwide status of aeromedical pre-hospital and retrieval medicine in Australia.

Objective: To survey the current structure, capability and operational scope of pre-hospital and retrieval aeromedical teams across Australia.

Methods: The medical directors of all Australian civilian adult aeromedical retrieval organisations with pre-hospital teams and/or doctors for inter-hospital critical care patient transport were contacted in a survey to qualitatively assess capacity and team structure.

Results: All 17 organisations contacted completed the survey.

Atmospheric concentrations and potential sources of dioxin-like contaminants to Acadia National Park.

Acadia National Park (ANP) is located on Mt. Desert Island, ME on the U.S.

Live cell screening to identify RNA-binding small molecule inhibitors of the pre-let-7-Lin28 RNA-protein interaction.

Dysregulation of the networking of RNA-binding proteins (RBPs) and RNAs drives many human diseases, including cancers, and the targeting of RNA-protein interactions (RPIs) has emerged as an exciting area of RNA-targeted drug discovery. Accordingly, methods that enable the discovery of cell-active small molecule modulators of RPIs are needed to propel this emerging field forward. Herein, we describe the application of live-cell assay technology, RNA interaction with protein-mediated complementation assay (RiPCA), for high-throughput screening to identify small molecule inhibitors of the pre-let-7d-Lin28A RPI.