Antimicrobial, antioxidant, and cytotoxic properties of biosynthesized copper oxide nanoparticles (CuO-NPs) using DC.

Nanoparticles produced from various metal elements including copper have been used in the treatment of infectious diseases in response to antibiotic failure due to microbial resistance. Copper is recommended for use in the production of nanoparticles largely because of its accessibility and affordability. This study aimed to synthesise copper oxide nanoparticles (CuO-NPs) using leaf extracts of and assess their antibacterial, antioxidant and cytotoxicity properties.

Metabolomic profile of medicinal plants with anti-RVFV activity.

Twenty medicinal plants with previously established anti-viral activity against a wild-type RVFV were further investigated using bio-chemometric and analytical techniques. The aim being to identify compounds common in plants with anti-RVFV activity, potentially being the major contributors to the anti-viral effect. Proton nuclear magnetic resonance (H NMR) spectroscopy coupled with multivariate data analysis (MVDA) was applied to characterize metabolite profiles of twenty antiviral medicinal plants.

The attenuation of antibiotic resistant non-albicans species, cytotoxicity, anti-inflammatory effects and phytochemical profiles of five species by FTIR and UHPLC-Q/Orbitrap/MS.

This work investigated the antifungal, cytotoxic and LPS-induced anti-inflammatory effects of five species (, , and ). The antifungal activity of the aqueous-methanolic extracts were performed using the broth dilution method against four non-albicans species (, and ). The cytotoxic and anti-inflammatory effects of the extracts were evaluated on African green monkey Vero kidney cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay and the 2',7'-dichlorofluorescin diacetate (HDCF-DA) method.

Metabolomic Profiling of Antioxidant Compounds in Five Species.

The genus , previously known as Acacia, belongs to the family Fabaceae, subfamily Leguminosae, which are flowering plants, commonly known as thorn trees. They are traditionally used medicinally in various countries including South Africa for the treatment of ailments such as fever, sore throat, Tuberculosis, convulsions and as sedatives. The aim of this study was to determine biochemical variations in five species and correlate their metabolite profiles to antioxidant activity using a chemometric approach.

Lithium inhibits NF-κB nuclear translocation and modulate inflammation profiles in Rift valley fever virus-infected Raw 264.7 macrophages.

Introduction: Rift Valley fever virus (RVFV) is a zoonotic life-threatening viral infection endemic across sub-Saharan African countries and the Arabian Peninsula; however, there is a growing panic of its spread to non-endemic regions. This viral infection triggers a wide spectrum of symptoms that span from fibril illnesses to more severe symptoms such as haemorrhagic fever and encephalitis. These severe symptoms have been associated with dysregulated immune response propagated by the virulence factor, non-structural protein (NSs).