Amelogenin Peptide-Chitosan Hydrogel for Biomimetic Enamel Regrowth.

We designed synthetic peptides that have demonstrated an effective remineralization potential to restore incipient enamel decay. In order to develop a clinically viable approach we incorporated the amelogenin-derived peptides P26 and P32 into chitosan hydrogel and examined their efficacy in the remineralization of enamel. Peptides in chitosan exhibited increased stability as compared to peptides in solution at room temperature and at 37°C.