A prospective randomized comparison of simultaneous integrated boost with sequential boost intensity-modulated radiotherapy in locally advanced head and neck cancer.

Purpose: A comparison of simultaneous integrated boost (SIB) with sequential boost (SEQ) using intensity-modulated radiotherapy along with concurrent cisplatin in locally advanced head and neck cancer (HNC) was made with regard to their survival outcomes and toxicity profile.

Materials And Methods: A total of 34 patients were enrolled between October 2016 and March 2019. They were randomized into two arms, SIB and SEQB.

An alternative yogic approach for cyclical mastalgia-A narrative review.

Background: Mastalgia or breast pain common benign breast disorder in women in her reproductive life. Mastalgia estimate prevalence 41-71%. It affects to overall quality of life and associated with anxiety, stress, and other psychological factors.

Organo-Photoredox Catalyzed Oxidative Dehydrogenation of N-Heterocycles.

We report here for the first time the catalytic oxidative dehydrogenation of N-heterocycles by a visible-light organo-photoredox catalyst with low catalyst loading (0.1-1 mol %). The reaction proceeds efficiently under base- and additive-free conditions with ambient air at room temperature.

Earth Abundant Iron-Rich N-Doped Graphene Based Spacer and Cavity Materials for Surface Plasmon-Coupled Emission Enhancements.

We demonstrate for the first time the use of Fe-based nanoparticles on N-doped graphene as spacer and cavity materials and study their plasmonic effect on the spontaneous emission of a radiating dipole. Fe-C-MF was produced by pyrolizing FeOOH and melamine formaldehyde precursor on graphene, while Fe-C-PH was produced by pyrolizing the Fe-phenanthroline complex on graphene. The use of the Fe-C-MF composite consisting of Fe-rich crystalline phases supported on N-doped graphene presented a spacer material with 116-fold fluorescence enhancements.

Cobalt-Catalyzed Bis-alkynylation of Amides via Double C-H Bond Activation.

The first example of cobalt-catalyzed selective bis-alkynylation of amides via double C-H bond activation with the directing assistance of a removable bidentate auxiliary is reported. The developed alkynylation strategy is simple, efficient, and tolerant of various functional groups including ether, amine, halides, and heterocyclic motifs. The reaction can be scaled up under mild conditions.

Well-defined palladium(ii) complexes for ligand-enabled C(sp(3))-alkynylation.

The first example of ligand-enabled C(sp(3))-alkynylation of 8-methylquinoline is reported. The reaction is catalysed by well-defined Pd(ii) complexes. The present C(sp(3))-alkynylation has a broad substrate scope as well as functional group tolerance and proceeds efficiently under mild conditions.