THE RELATIONSHIP BETWEEN THE CONDITION OF THE ORAL CAVITY AND THE USE OF TOBACCO PRODUCTS IN DIFFERENT AGE GROUPS.

Unlabelled: Understanding the harmful effects of using tobacco products (cigarettes, electronic cigarettes (e-cigarette) or vape, IQOS, hookah, etc.) by various segments of the population is one of the important ways to improve the condition of the tissues of the oral cavity, since smoking is an important risk factor for the occurrence of chronic destructive periodontal diseases. The purpose of our work was a study of the relationship between the state of the oral cavity and the use of tobacco products in different age groups based on the conducted questionnaire.

PECULIARITIES OF IMMUNE STATUS IN THE PRESENCE OF SECONDARY IMMUNODEFICIENCY OF INFECTIOUS AND NON-INFECTIOUS ORIGIN IN WOMEN OF REPRODUCTIVE AGE.

The design of studies on the immune system does not have gender peculiarities, but the information about the higher frequency of pathology of the female reproductive system in the presence of immunodeficiency condition determines the purpose of this study, namely, to identify the features of immune status in the presence of secondary immunodeficiency of infectious (i.e., HIV infection, AIDS stage) and non-infectious origin (alcohol dependence syndrome) and their combination in women of reproductive age.

PEDAGOGICAL ASPECTS OF THE IMPACT OF SMOKING ON THE HUMAN BODY BASED ON RADIOGRAPHIC DENSITY INDICATORS OF MAXILLARY SINUS BONE WALLS.

The most effective process of quitting smoking can be achieved through precise and complete identification of the adverse effects on the human body. The aim was to examine the influence of smoking on the density of the walls of the paranasal sinuses. 80 individuals of the young age and both genders were included into the research.

THE SIGNIFICANCE OF ISCHEMIA FOR THE PROLIFERATIVE ACTIVITY OF THE MUCOSA IN INFLAMMATORY BOWEL DISEASES.

The state of the microcirculatory bed remains one of the determining factors in course of inflammatory bowel diseases (IBD). The presence of small foci of ischemia could realize in dystrophic-necrobiotic consequences, which can also underlie the development or strengthening of the inflammatory process. Based on above, the goal of our study was to determine the impact of the development of mucosal ischemia in the colon on the activity of proliferative processes during inflammation.

Cytological transformation of the cervix in immunodeficiency aggravated by alcoholism.

Unlabelled: Comorbid pathology, high mortality and disability remain an urgent problem for people with the development of an immunodeficiency state, including women of reproductive age. Prognostic triggers could help to improve management of preneoplastic injury of cervical epithelium.

Aim: The aim of this study was to identify the cytological features of the cervical epithelium in women with immunodeficiency status and alcoholism, depending on the level of CD4-lymphocytes.

THE INFLUENCE OF IMMUNODEFICIENCY ON THE LEVEL OF CD34-POSITIVE CELLS IN THE CERVIX.

There are many studies on changes in cervix, however, there are no data about property of cervical tissue to keep potential for regeneration under influence of immunodeficiency, which is very important since it allows escaping severe irreversible changes in tissue. CD34 stem cells are one of significant indicator for property of tissual regeneration. So, the purpose of our study was to identify amount of CD34 stem cells in the cervix under influence of immunodeficiency of infectious and non-infectious origin.

Importance of antimicrobial factors for microbiocenosis and local immunity of the oral cavity in children with mucoviscidosis.

Unlabelled: The involvement of commensals and opportunistic pathogens and the role of protective mechanisms in the development of dental diseases in children with cystic fibrosis require more detailed study.

Aim: The aim of the study was to determine the ecological characteristics of the oral microbiota and some antimicrobial factors of saliva in children with mucoviscidosis.

Materials And Methods: The study involved an assessment of oral microbiota as complex ecological system that protects the human body from colonization by pathogenic flora in children with cystic fibrosis.

MORPHO-FUNCTIONAL CHANGES IN ENDOMETRIUM UNDER THE INFLUENCE OF CHRONIC ALCOHOLISM.

According to data that would have been obtained precisely as a result of studying the changes caused by alcohol abuse in the female body which can help solve many abnormal conditions developing in the female reproductive system, such as oligodysmenorrhea and amenorrhea, the purpose of this study was to identify changes in the endometrium that occur in chronic alcoholism. The study included sectional material, selected from women who, according to history data (interviews with relatives) and autopsy data (presence of alcoholic cirrhosis of the liver), had confirmed alcohol abuse. Microscopic examination of endometrium was carried out followed by morphometric examination with determining: the average diameter of the endometrial glands, the minimum diameter of the endometrial glands, the maximum diameter of the endometrial glands, gland wall thickness, the relative volume of the epithelium, and the thickness of the epithelium for the proliferative or secretory type of the endometrium.

A METHOD OF COMPLEX EVALUATION OF MORPHOLOGICAL STRUCTURE OF OSTIOMEATAL COMPLEX COMPONENTS, LOWER WALL OF MAXILLARY AND FRONTAL SINUSES.

Objective: The aim: Was to evaluate the anatomical variability of the frontal and maxillary sinuses, ostiomeatal complex components (OMC) and to identify factors that contribute to complications of inflammatory processes and development of odontogenic maxillary sinusitis.

Patients And Methods: Materials and methods: The study involved assessment of 100 spiral computed tomograms (SCT) of human patients without pathological processes in the PNS area. The basic parameters of the anatomical structure of the ostiomeatal complex (the area of the hooked process and the middle nasal conch, their transverse dimensions, the density and dimensions of the natural connection), the thickness and the density of the lower wall of the maxillary and frontal sinuses were determined.

Influence of neoadjuvant chemoradiotherapy for locally advanced cervical cancer.

Unlabelled: Over the past decade, there are significant advances in the problem of studying the pathogenesis, clinical course and treatment of cervical cancer (CC). Namely the need for more favorable treatment outcomes for locally advanced cervical cancer requires the development of more effective treatments.

Aim: The aim of our work was to study the consequences of neoadjuvant chemoradiation therapy (NCRT) in the management of locally advanced cervical cancer by assessing morphological changes in the tumor tissue.

Application of estimated oral health indices in adolescents with tobacco addiction.

Unlabelled: It is known that every day 2,500 children under the age of 18 try their first cigarette, and more than 400 of them become new, regular smokers, and half of them will die from this addiction in the future.

Aim: The aim of the study is to determine changes in the indices of dental status in adolescents with tobacco smoking.

Materials And Methods: The study involved 54 adolescents aged 12 to 18 years.

Implementation and analysis of Babesia immunoassay testing.

Unlabelled: Lifelong withdrawal from the donor population of those who have been diagnosed with babesiosis must be used for transmission prevention.

Aim: The aim of the study was a detection of Babesia antibodies level with the usage of experimental Babesia divergens whole-cell slide antigen and commercial B. microti immunofluorescence assay substrate slide (Fuller Laboratories, USA).

INFLUENCE OF ENDOTHELIOPATHY OF SPIRAL ARTERIES ON PLACENTAL ISCHEMIA.

Recently, worldwide authors have paid particular attention to vascular endothelium in the mother-placenta-fetus system for the understanding of development of vascular network and its normal functioning, possible gestational endotheliopathy. Endothelial dysfunction is important in the development of thrombosis, neoangiogenesis and vascular remodeling, being the key to the development of obstetric and perinatal disorders. The aim of the study was to reveal morphological signs of endotheliopathy in spiral arteries in preeclampsia, which is important for understanding the development of pregnancy complications.

ANALYSIS OF LOCAL IMMUNITY INDICATORS OF THE ORAL CAVITY AND DEGREE OF GINGIVITIS DEPENDING ON MUTATION OF CFTR GENE IN CHILDREN WITH CYSTIC FIBROSIS.

The aim of the work was to establish the relationship between the genotype of the cystic fibrosis transmembrane conductance regulator (CFTR), the level of local immune reactivity and the degree of chronic gingivitis in children with cystic fibrosis. The study has shown significant differences in the local immunity indices of the oral mucosa and the condition of periodontal tissues in children with cystic fibrosis in comparison with the control group. The features of the course of dental pathology among sick children, depending on the type of CFTR gene mutation are determined.

CONSEQUENCES OF MICROSEQUENCES OF MICROCIRCULATORY DISTRURBANCES OF ORAL MUCOSA IN MODELING OF RHEUMATOID ARTHRITIS.

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia and the destruction of cartilage and bone with unclear morphogenesis of pathological changes in oral cavity. Simultaneously microcirculatory disturbance is important link of pathogenesis in many pathological conditions in oral cavity with inflammatory consequences. The aim of this study was to determine importance of microcirculatory disturbance of oral mucosa in modeling of rheumatoid arthritis.

Anaplasmosis: experimental immunodeficient state model.

Objective: Introduction: The recently described anaplasmosis infection is widespread but concerns to the insufficiently known group of diseases. The aim of our research is the development of uniform biological model for reproducing of artificial immunodeficient state by experimental anaplasmosis.

Patients And Methods: Materials and methods: Algorithm of experimental anaplasmosis reproducing, consisted of such consecutive stages: 1) artificial forming of the immunodeficient state at nonlinear white mise (Mus musculus L.

ULTRASTRUCTURAL CHANGES IN THE ORGANS OF THE IMMUNE SYSTEM UNDER THE INFLUENCE OF XENOBIOTICS.

Nowadays scientific achievements in various areas of lives have caused the creation of more and more «foreign body substances» known as xenobiotics. As it is widely accepted that human health is a product of both genetics and the environment; and premise that also holds true for the immune system with unclear morphogenetic aspect, so we selected the purpose of our work as detection of ultrastructural changes in the spleen and thymus under the influence of tryglycidyl ether of polyoxypropylenetriol (TEPPT) and propylene glycol (PP). Subacute experiment has been performed on the matured male rat's with administration of 1/10 LD50 and 1/100 LD50 of TEPPT and PP during 7 days, 15 days, 30 days and 45 days.

INFLUENCE OF TRICALCIUM SILICATE ON COURSE OF TRAUMATIC PULPITIS.

The use of Tricalcium Silicate (TS) as an odontotropic preparation makes it possible to create a hermetic crown restoration with a high degree of adhesion. However, the use of TS silicate by direct pulp capping remains disputable. The aim of this study was to determine the effects of TS on course of traumatic pulpitis by detection of morpho-functional peculiarities of changes in pulp tissue.

MICROSCOPIC FEATURES OF THE SPLEEN UNDER THE INFLUENCE OF LAPROXIDES.

Rapid technology growth and its implementation in all spheres of the people's lives dictates the necessity for thorough study of the influence of different chemicals on human's health. This study was undertaken to elucidate the structural changes that occur in the matured rats' spleen experimentally induced by selected xenobiotic, so, purpose of our work was detection of microscopic peculiarities of the spleen under the influence of laproxides. In subacute experiment were uncovered organometric alterations of the matured male rat's spleen after the administration of 1/10 LD50 of polyether-tryglycidyl ether of polyoxypropylene triol (TEPPT).

INTERRELATION OF THE GENE 4DKN1A (RS 1801270) POLYMORPHIC STATE AND LEVEL OF DEVELOPMENT OF CARIES IN CHILDREN WITH DOWN SYNDROME.

Study is devoted for rs1801270 polymorphism of CDKN1A gene due to the level of intensity of caries development in children with Down syndrome. The full development of oral cavity organs is ensured through a complex of genes whose protein products control different stages of this difficult process. Changes in gene structure, as well as disturbance of their expression may lead to abnormalities of development of teeth and periodontal tissues.

INFLUENCE OF METABOLIC SYNDROME ON CONDITION OF MICROCIRCULATORY BED OF ORAL CAVITY.

Metabolic syndrome (MS) can be characterized as the clustering of combination of impaired glucose regulation, metabolic disorders accompanied by abdominal obesity, hyperglycemia, high blood pressure and dyslipidemia. Detection of changes in microcirculatory bed (MCB) of oral cavity in metabolic syndrome could be important for completion of gap for developing of adequate therapeutical measure for prevention of pathological periodontal disorder that was the purpose of our study. We performed experimental investigation with modulation of MS (on white male rats 1.

Pathomorphological peculiarities of tuberculous meningoencephalitis associated with HIV infection.

Background And Aims: One of the most severe manifestation displays of tuberculosis (TB) generalization is meningitis/meningoencephalitis. The purpose of this work was to improve the diagnostic efficiency of TB central nervous system (CNS) affection in human immunodeficiency virus (HIV)-infected persons.

Materials And Methods: Meninges and cerebral tissues, taken from died patients, who were HIV-infected and dead from TB of CNS affection, were investigated histologically.

CERVICAL TRANSFORMATION IN ALCOHOL ABUSE PATIENTS.

Patients with alcohol consumption have unclear risk of developing cervical cancer. The purpose of our work was detection of cervical neoplastic transformation in women with alcohol abuse. We investigated 13 cases of cervical neoplastic transformation (5 cases of invasive carcinoma and 8 case of cervical intraepithelial neoplasia (CIN)) which where detected occasionally during autopsy of alcohol abuse women.