Publications by authors named "Garcimarero-Espino E Alejandra"
Several studies have been reported for the preparation of hexacyclic-steroid derivatives; however, some reagents are expensive and require special conditions for handling. In this way, the objective of this study was to synthesize a hexacyclic-steroid derivative from 4-hydroxyestrone. The chemical structure was evaluated through both H NMR and C NMR spectroscopic analysis.
View Article and Find Full Text PDFDesign and Synthesis of an Aniline Derivative with Biological Activity on Heart Failure.
Comb Chem High Throughput Screen
September 2021
Article Synopsis
- Several aniline derivatives were synthesized as potential treatments for heart failure, requiring a series of chemical reactions to create them.
- The study found that one specific compound (compound 8) notably reduced heart failure symptoms and infarction area more effectively than other synthesized compounds.
- This research suggests an efficient and cost-effective method for creating these derivatives, while also highlighting compound 8's unique biological activity, which may work through a different mechanism compared to existing heart failure medications.
There are several reports for the preparation of furan derivatives using some protocols which requires special conditions. In this way, the aim of this study was to synthesize a new furan-steroid-propanone derivative from both 17α-ethynylestradiol and 2-nitro-17α-ethynylestradiol using some series of reactions such as aldolization, 2 + 2 addition and etherification. The chemical structure was evaluated through both H NMR and C NMR spectroscopic analysis.
View Article and Find Full Text PDFArticle Synopsis
- * Compounds 4 and 5 were highlighted for their significant ability to reduce heart failure symptoms, specifically by decreasing the infarct area compared to other tested compounds.
- * Both compounds lowered left ventricular pressure in a dose-dependent way, and this effect was significantly blocked by the presence of methoctramine, indicating their action involves M-muscarinic receptor activation.
Synthesis and Biological Activity of a Bis-steroid-Methanocyclobutanaphthalene- dione Derivative against Ischemia/Reperfusion Injury via Calcium Channel Activation.
Antiinflamm Antiallergy Agents Med Chem
July 2021
Article Synopsis
- There is a need to better understand how certain steroid derivatives impact ischemia/reperfusion injury, as previous experimental data has shown mixed results possibly due to varying chemical structures and testing methods.
- The study aimed to create a new bis-steroid-methanocyclobutanaphthalene-dione derivative and tested its effects on an isolated heart model against ischemia/reperfusion injury, using several control drugs.
- The findings indicated that the new derivative significantly reduced injury and increased left ventricular pressure, suggesting it could activate calcium channels and serve as a potential new treatment for ischemia/reperfusion injury.