Gene flow throughout the evolutionary history of a colour polymorphic and generalist clownfish.

Even seemingly homogeneous on the surface, the oceans display high environmental heterogeneity across space and time. Indeed, different soft barriers structure the marine environment, which offers an appealing opportunity to study various evolutionary processes such as population differentiation and speciation. Here, we focus on Amphiprion clarkii (Actinopterygii; Perciformes), the most widespread of clownfishes that exhibits the highest colour polymorphism.

BCG priming followed by a novel interleukin combination activates Natural Killer cells to selectively proliferate and become anti-tumour long-lived effectors.

The short-lived nature and heterogeneity of Natural Killer (NK) cells limit the development of NK cell-based therapies, despite their proven safety and efficacy against cancer. Here, we describe the biological basis, detailed phenotype and function of long-lived anti-tumour human NK cells (CD56CD16), obtained without cell sorting or feeder cells, after priming of peripheral blood cells with Bacillus Calmette-Guérin (BCG). Further, we demonstrate that survival doses of a cytokine combination, excluding IL18, administered just weekly to BCG-primed NK cells avoids innate lymphocyte exhaustion and leads to specific long-term proliferation of innate cells that exert potent cytotoxic function against a broad range of solid tumours, mainly through NKG2D.

Can the microcystic, elongated and fragmented pattern of invasion influence the evaluation of the depth of myometrial invasion in low-grade endometrioid endometrial cancer using imaging techniques?

Objectives: The microcystic, elongated and fragmented pattern of invasion can be associated with an underestimation of the depth of myometrial invasion by imaging techniques. We aimed to evaluate the influence of microcystic, elongated and fragmented pattern of invasion in the diagnostic performance of transvaginal ultrasound scan and magnetic resonance imaging for the prediction of the depth of myometrial invasion in low-grade endometrioid endometrial carcinomas.

Methods: Prospective and consecutive study including all low-grade (G1-G2) endometrioid endometrial carcinomas diagnosed between October 2013 and July 2018 in a tertiary hospital.

Information manipulation and historical revisionism: Russian disinformation and foreign interference through manipulated history-based narratives.

Disinformation and historical revisionism have been acknowledged as tools for foreign interference that belong to the landscape of hybrid threats. Historical revisionism plays an essential role in Russian foreign policy towards the post-Soviet space and is in strong relation with the concepts of Near Abroad and Russkii Mir ('Russian World') and with certain ideas contained in the neo-Eurasianist Movement. This article examines Russian revisionist narratives disseminated in information and influencing campaigns in Europe and against the West.

BCG-activation of leukocytes is sufficient for the generation of donor-independent innate anti-tumor NK and γδ T-cells that can be further expanded .

Bacillus Calmette-Guérin (BCG), the nonpathogenic strain used as tuberculosis vaccine, has been successfully used as treatment for non-muscle invasive bladder cancer for decades, and suggested to potentiate cellular and humoral immune responses. However, the exact mechanism of action is not fully understood. We previously described that BCG mainly activated anti-tumor cytotoxic NK cells with upregulation of CD56 and a CD16 phenotype.

Liquid-liquid and liquid-solid separation in self-assembled chitosan-alginate and chitosan-pectin complexes.

The complexation between two oppositely charged polyelectrolytes (PE) can lead liquid-liquid (complex coacervates, CC) or liquid-solid (solid precipitates, SP) phase separations. Herein, the effect of pH (2-11) and ionic strength (I, 0.05-1.

Suspect glaucoma detection from corneal densitometry supported by machine learning.

Purpose: To discriminate suspect glaucomatous from control eyes using corneal densitometry based on the statistical modeling of the pixel intensity distribution of Scheimpflug images.

Methods: Twenty-four participants (10 suspect glaucomatous and 14 control eyes) were included in this retrospective study. Corneal biomechanics was assessed with the commercial Scheimpflug camera Corvis ST (Oculus).

Mechanical ventilation in Spain, 1998-2016: Changes in the disconnection of mechanical ventilation.

Purpose: To evaluate changes in the disconnection of mechanical ventilation in Spain from 1998 to 2016.

Design: Post-hoc analysis of four cohort studies.

Ambit: 138 Spanish ICUs.

Mechanical ventilation in Spain, 1998-2016: changes in the disconnection of mechanical ventilation.

Purpose: To evaluate changes in the disconnection of mechanical ventilation in Spain from 1998 to 2016.

Design: Post-hoc analysis of four cohort studies.

Ambit: 138 Spanish ICUs.

Survival outcomes and prognostic factors of endometrial stromal sarcoma and undifferentiated uterine sarcoma.

Purpose: To review the diagnostic and therapeutic procedures of patients diagnosed with Endometrial Stromal Sarcoma (ESS) and Undifferentiated Uterine Sarcoma (USS) at our institution and investigate their clinical outcomes and factors affecting prognosis.

Methods: We retrospectively collected demographic data, preoperative diagnostic methods and therapeutic management of patients treated for ESS and UUS between January 1995 and December 2019 at Vall d'Hebron Barcelona Hospital Campus, Spain. Overall survival and disease-free survival were calculated.

Silicon flow from root to shoot in pepper: a comprehensive in silico analysis reveals a potential linkage between gene expression and hormone signaling that stimulates plant growth and metabolism.

Background: Silicon (Si) is categorized as a -essential element for plants thanks to the benefits on growth, development and metabolism in a hormetic manner. Si uptake is cooperatively mediated by Lsi1 and Lsi2. Nevertheless, Lsi channels have not yet been identified and characterized in pepper (), while genes involved in major physiological processes in pepper are Si-regulated.

Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells.

Peroxiredoxin 6 (PRDX6) has been associated with tumor progression and cancer metastasis. Its acting on phospholipid hydroperoxides and its phospholipase-A2 activity are unique among the peroxiredoxin family and add complexity to its action mechanisms. As a first step towards the study of PRDX6 involvement in cancer, we have constructed a human hepatocarcinoma HepG2 cell line using the CRISPR/Cas9 technique and have characterized the cellular response to lack of PRDX6.

Study of tyrosine and dopa enantiomers as tyrosinase substrates initiating l- and d-melanogenesis pathways.

Tyrosinase starts melanogenesis and determines its course, catalyzing the oxidation by molecular oxygen of tyrosine to dopa, and that of dopa to dopaquinone. Then, nonenzymatic coupling reactions lead to dopachrome, which evolves toward melanin. Recently, it has been reported that d-tyrosine acts as tyrosinase inhibitor and depigmenting agent.

Mechanical ventilation in Spain, 1998-2016: Epidemiology and outcomes.

Purpose: To evaluate changes in the epidemiology of mechanical ventilation in Spain from 1998 to 2016.

Design: A post hoc analysis of four cohort studies was carried out.

Setting: A total of 138 Spanish ICUs.

Silicon induces hormetic dose-response effects on growth and concentrations of chlorophylls, amino acids and sugars in pepper plants during the early developmental stage.

Background: Silicon (Si) is a beneficial element that has been proven to influence plant responses including growth, development and metabolism in a hormetic manner.

Methods: In the present study, we evaluated the effect of Si on the growth and concentrations of chlorophylls, total amino acids, and total sugars of pepper plants ( L.) during the early developmental stage in a hydroponic system under conventional (unstressed) conditions.

Spontaneous Uterine Rupture in the Second Trimester in a Patient With Previous Pelvic Radiotherapy in Childhood: A Case Report.

Background: Pelvic irradiation in childhood may result in abnormal uterine function. Poor obstetric outcomes have been reported in these patients.

Case: A 30-year-old woman with a previous midtrimester miscarriage, G2, P0, presented at 23 weeks gestation with acute abdominal pain and signs of hemodynamic instability.

Chondrosarcoma of the Hand Bones: A Report of 6 Cases and Review of the Literature.

Background: Primary malignant tumours of the hand are extremely rare, with chondrosarcoma being the most common. We describe six consecutive cases of chondrosarcoma (CS) of the hand, with a follow-up of 12 months to 10 years after surgical intervention.

Methods: Five cases were primary tumors and one was secondary to Ollier's disease.

[Embolizing cardiac hibernoma and acute respiratory failure].

Not only ae cardiac hibernomas rare, ante-mortem diagnosis is poor, due to the clinical and radiological similarity with other intracardiac masses. Furthermore, cardiac hibernomas can be asymptomatic and thus escape detection with imaging studies. We present a case of an 81-year-old woman who died as a result of pulmonary tumor embolism.

Vaginal Intraepithelial Neoplasia: Clinical Presentation, Management, and Outcomes in Relation to HIV Infection Status.

Objectives: The data available on vaginal intraepithelial neoplasia (VAIN) and infection by HIV are scarce. We therefore aimed to review the clinical presentation, management, and survival outcomes of VAIN in this group of women.

Materials And Methods: This is an observational cohort study of women diagnosed with VAIN for a 23-year period.

Vanadium stimulates pepper plant growth and flowering, increases concentrations of amino acids, sugars and chlorophylls, and modifies nutrient concentrations.

Vanadium (V) can be absorbed by plants and regulate their growth and development, although contrasting effects have been reported among species and handling conditions. The objective of this work was to evaluate the beneficial effect of V on pepper plants (Capsicum annuum L.).