Publications by authors named "Garcia-Carrodeguas R"
Analysis of Tissue Repair of a New Cement Based on Calcium and Strontium Aluminates: A Triple-Blinded, Randomized, Controlled Trial in an Animal Model.
Eur J Dent
October 2024
Objective: The focus of this triple-blind randomized study was to evaluate the biocompatibility of a new root canal filling sealer (RCFS) based on tristrontium aluminate and dodecacalcium hepta-aluminate in living tissue.
Material And Methods: Forty-five Wistar rats () were divided into three groups: control (polyethylene), sealer (Bio-C Sealer, Londrina, PR, Brazil), and experimental (tristrontium aluminate and dodecacalcium hepta-aluminate). The tissues were analyzed under an optical microscope to assess different cellular events at different time intervals (7, 15, and 30 days).
In order to provide favorable conditions for bone regeneration, a lot of biomaterials have been developed and evaluated, worldwide. Composite biomaterials have gained notoriety, as they combine desirable properties of each isolated material. Thus, in this research, bone repair capacity of three developed formulations of ceramic scaffolds were evaluated histomorphometrically, after implantation.
View Article and Find Full Text PDFNovel Osteoinductive and Osteogenic Scaffolds of Monetite, Amorphous Calcium Phosphate, Hydroxyapatite, and Silica Gel: Influence of the Hydroxyapatite/Monetite Ratio on Their Behavior and on Their Physical and Chemical Properties.
ACS Biomater Sci Eng
June 2020
Article Synopsis
- Scientists studied a new type of multiphasic material made from silica gel and different calcium phosphates with varying solubility levels to improve bone regeneration.
- They found that a certain ratio of hydroxyapatite to monetite is essential for balancing how quickly the material breaks down and how well it helps bones heal, with physical properties being more important than solubility.
- The results showed that using materials with higher hydroxyapatite/monetite ratios led to better bone regeneration and blood vessel formation in sheep with critical bone defects.
Scaffolds are models designed to aid the interaction between cells and extracellular bone matrix, providing structural support for newly formed bone tissue. In this work, wollastonite with β-TCP porous ceramic scaffolds was developed by the polymer sponge replication. Their microstructure, cell viability and bioactivity were tested.
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- β-dicalcium silicate (β-C₂ S) is a key component in Portland cement and acts as a hydraulic cement, providing strength through its reaction with water to form a hydrated phase.
- The study synthesized β-C₂ S using a sol-gel process to create a new type of cement called CSiC, and evaluated its bioactivity and biocompatibility through tests in simulated body fluids and human cell cultures.
- Results indicated that the sol-gel method effectively produced a pure β-C₂ S powder at low temperatures, forming a bone-like layer on its surface and exhibiting compressive strength similar to human bone, while also showing non-toxic effects on cell growth.
The purpose of the current study was to investigate whether the cryopolymerization technique is capable of producing suitable scaffolds for bone tissue engineering. Cryopolymers made of 2-hydroxyethyl methacrylate and acrylic acid with (W1 and W20) and without (W0) wollastonite particles were prepared. The elastic modulus of the specimens rose one order of magnitude from W1 to W20.
View Article and Find Full Text PDFComposite materials are very promising biomaterials for hard tissue augmentation. The approach assayed in this work involves the manufacturing of a composite made of a bioactive ceramic, natural wollastonite (W) and a nanostructured copolymer of ethylmethacrylate (EMA) and vinylpyrrolidone (VP) to yield a bioresorbable and biocompatible VP-EMA copolymer. A bulk polymerization was induced thermally at 50 degrees C, using 1 wt % azobis(isobutyronitrile) (AIBN) as free-radical initiator.
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