Publications by authors named "Garcia Pembele"
Article Synopsis
- Monitoring the effectiveness of antimalarial treatments in Angola is crucial for identifying potential drug resistance, with studies conducted biennially in specific provinces.
- In a recent study involving 622 children treated with various antimalarial drugs, the majority achieved positive outcomes by day 3, while overall efficacy rates varied across treatments and locations.
- The findings indicated that, while some drugs exhibited high efficacy, artemether-lumefantrine (AL) showed concerning lower effectiveness (below 90%) in Zaire, reinforcing the need for alternative therapies like ASAQ, DP, and ASPY.
Continued Low Efficacy of Artemether-Lumefantrine in Angola in 2019.
Pedro Rafael Dimbu Roberta Horth Ana Luísa M Cândido Carolina Miguel Ferreira Felismina Caquece Garcia Pembele
Antimicrob Agents Chemother
January 2021
Biennial therapeutic efficacy monitoring is a crucial activity for ensuring the efficacy of currently used artemisinin-based combination therapy in Angola. Children with acute uncomplicated infection in sentinel sites in the Benguela, Zaire, and Lunda Sul Provinces were treated with artemether-lumefantrine (AL) or artesunate-amodiaquine (ASAQ) and monitored for 28 days to assess clinical and parasitological responses. Molecular correction was performed using seven microsatellite markers.
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