Publications by authors named "Garcia M"

Article Synopsis
  • Educational workshops on inclusive research practices were held at the University of Wisconsin-Madison from October 2022 to August 2023, focusing on improving study diversity and health equity.
  • Evaluation involved 80 participants across 4 cohorts, using pre/post-test surveys to measure knowledge and self-efficacy changes.
  • Results showed significant improvements post-workshop, with 85.7% of follow-up survey respondents reporting they had implemented inclusive practices.
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  • Habituation is an important process that helps filter out sensory information, but when it doesn't work properly, it can cause overwhelming sensory experiences, especially in certain disorders.
  • The study found that daily habituation in the primary auditory cortex can be disrupted by inhibiting the orbitofrontal cortex, which plays a critical role in this sensory filtering process.
  • Specifically, the ventrolateral section of the orbitofrontal cortex sends predictive signals that adapt with daily sound experiences, helping to suppress irrelevant auditory information through specialized inhibitory neurons.
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Objective: The purpose of this study is to adapt cross-culturally to Chilean Spanish the assessment scale "Balance Assessment Systems (Mini-BESTest)" so that it can be applied to patients with stroke. Since stroke is a syndrome that compromises the patient's balance, an essential ability to perform activities of daily living safely, the study of different alternatives to improve the living conditions of patients is considered essential.

Materials And Methods: Observational, descriptive, cross-sectional study.

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Bone loss is a prevalent characteristic among people with HIV (PWH). We focused on mesenchymal stem cells (MSCs) and osteoblasts, examining their susceptibility to different HIV strains (R5- and X4-tropic) and the subsequent effects on bone tissue homeostasis. Our findings suggest that MSCs and osteoblasts are susceptible to R5- and X4-tropic HIV but do not support productive HIV replication.

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Lung cancer remains the leading cause of cancer-related mortality worldwide with non-small cell lung cancer (NSCLC) accounting for the majority of cases. The stage of detection significantly influences survival rates with early-stage diagnosis offering the best prognosis. This study investigates the prognostic impact of the omega-6/omega-3 ratio and tumor infiltration by CD8+ lymphocytes and CD68+ macrophages on overall survival (OS) and disease-free survival (DFS) in NSCLC patients undergoing pulmonary resection.

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The vascular endothelium is the first line of defense to prevent cardiovascular disease. Its optimal functioning and health are maintained by the interaction of the proteins-endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1), and endothelin 1 (ET1)-and the genes that encode them-, , and , respectively. Aerobic exercise improves endothelial function by allegedly increasing endothelial shear stress (ESS).

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Context: Adults perceive certain factors to increase or decrease the risk of sustaining running-related injuries, but many of their perceptions are not supported by research. Little is known about the perceptions that adolescent runners hold. Investigating perceptions for adolescent runners is needed to assist in the development of future injury educational materials, as these resources may need to be tailored differently for adolescents and adults.

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Background: Prader-Willi syndrome (PWS) is a congenital disease caused by a rare and generally non-inherited genetic disorder. The inability to recognise facial expressions of emotion is an apparent social cognition deficit in people diagnosed with PWS. The main objective of the present study is to compare the ability to recognise emotional facial expression, in both non-contextualised and contextualised scenarios, among the main subtypes of PWS and a control group.

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Purpose: Rhabdomyosarcoma (RMS) is the most common soft tissue cancer in children. Around 15% of RMS involve the bladder and/or prostate (BP). Overall survival is around 85%.

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Article Synopsis
  • The aftermath of Hurricane María in 2017 led to a significant migration of Puerto Ricans to the continental U.S., despite their territorial ties to the U.S. and distinct cultural identity.
  • The study focused on the experiences of 42 Puerto Rican parents who were displaced, using cultural stress theory and psychological sense of community to understand their challenges and resilience.
  • Findings reveal that these parents faced the loss of social connections and support networks in exchange for the potential economic and safety benefits in the U.S., highlighting their complex journey as cross-cultural migrants.
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Background: We evaluated outcomes in non-small cell lung cancer (NSCLC) patients who presented with brain-only metastatic (BOM) disease overall and by EGFR/ALK mutation status.

Methods: We analyzed clinico-demographic, treatment and survival data for all NSCLC patients who presented to our center between 2014 and 2016 with BOM as their first presentation of metastatic disease. Differences in overall survival (OS) were evaluated using log-rank tests for NSCLC wildtype (NSCLCwt NSCLC with an ALK-rearrangement/EGFR-mutation (NSCLCmut+).

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The E3 ubiquitin ligase TRAIP associates with the replisome and helps this molecular machine deal with replication stress. Thus, TRAIP promotes DNA inter-strand crosslink repair by triggering the disassembly of CDC45-MCM2-7-GINS (CMG) helicases that have converged on these lesions. However, disassembly of single CMGs that have stalled temporarily would be deleterious, suggesting that TRAIP must be carefully regulated.

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The demand for novel tissue grafting and regenerative wound care biomaterials is growing as traditional options often fall short in biocompatibility, functional integration with human tissue, associated cost(s), and sustainability. Salmon aquaculture generates significant volumes of waste, offering a sustainable opportunity for biomaterial production, particularly in osteo-conduction/-induction, and de novo clinical/surgical bone regeneration. Henceforth, this study explores re-purposing salmon waste through a standardized pre-treatment process that minimizes the biological content, followed by a treatment stage to remove proteins, lipids, and other compounds, resulting in a mineral-rich substrate.

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Breast cancer (BC) recurrence, defined as the reappearance of cancer in the ipsilateral breast after primary treatment, poses significant challenges in clinical management. Despite advances in treatment, recurrence rates persist, ranging from 0.6 to 1.

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Background: The prevalence of hypertension (HTN) has significantly increased among younger adults (15-45 yrs) in the U.S. Despite this, there is limited data on trends of HTN-related mortality within this population.

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Objectives: To identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort.

Methods: The first hospitalization after entry into the cohort during these patients' follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization.

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Article Synopsis
  • The municipality of Rio de Janeiro has enhanced its health surveillance strategies by integrating epidemic intelligence and technology, especially during the COVID-19 pandemic.
  • The Epidemiological Intelligence Center (CIE), opened in March 2022, utilizes a multiprofessional team and various data sources to facilitate early detection of public health trends.
  • The center has established a data lake to store health data related to COVID-19, created descriptive and analytical dashboards for different users, and implemented an alert panel to quickly respond to public health emergencies.
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Article Synopsis
  • Demand for computing power in major scientific experiments, like the CMS at CERN, is expected to significantly increase over the coming decades.
  • The implementation of coprocessors, particularly GPUs, in data processing workflows can enhance performance and efficiency, especially for machine learning tasks.
  • The Services for Optimized Network Inference on Coprocessors (SONIC) approach allows for improved use of coprocessors, demonstrating successful integration and acceleration of workflows across various environments without sacrificing throughput.
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The efficiency of a staged photocatalytic reactor prototype was evaluated on a semi-pilot scale with the removal of acetaminophen, for which anatase particles were synthesized by Sol-Gel and impregnated on rectangular plates of clay. X-ray diffraction and Energy Dispersive X-ray Fluorescence patterns show that the final composite is made up of AlO (14 %), SiO (41 %), CaO (3 %) TiO (34 %), and FeO (7 %). The impregnation method favors the dispersion of Anatase on the surface of the adsorbent.

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Introduction: Polymeric nanoparticles used for antigen delivery against infections and for cancer immunotherapy are an emerging therapeutic strategy in promoting the development of innovative vaccines. Beyond their capability to create targeted delivery systems with controlled release of payloads, biodegradable polymers are utilized for their ability to enhance the immunogenicity and stability of antigens.

Areas Covered: This review extensively discusses the physicochemical parameters that affect the behavior of nanoparticles as antigen-delivery systems.

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Introduction: In recent years, chimeric antigen receptor T (CAR-T) cell therapy has resulted in a breakthrough in the treatment of patients with refractory or relapsed hematological malignancies. However, the identification of patients suitable for CAR-T cell therapy needs to be improved.

Areascovered: CAR-T cell therapy has demonstrated excellent efficacy in hematological malignancies; however, views on determining when to apply CAR-T cells in terms of the evaluation of patient characteristics remain controversial.

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Deconvolution and convolution are powerful tools that allow decomposition and reconstruction, respectively, of plasma versus time profiles from input and impulse functions. While deconvolution have commonly used compartmental approaches (e.g.

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