Publications by authors named "Garcia J"

Article Synopsis
  • Prostate cancer is a major cause of cancer-related deaths in European men, highlighting the need for better risk assessment tools, particularly focusing on the P72R SNP in the TP53 gene that may increase susceptibility to the disease.
  • A study examined the prevalence of the P72R SNP in different prostate cancer samples and found significantly higher rates in cancer patients compared to a non-cancer control group, indicating a strong association with risk of aggressive prostate cancer.
  • The findings suggest that the P72R SNP could serve as a valuable marker for identifying individuals at risk for aggressive forms of prostate cancer, paving the way for early intervention and better treatment strategies.
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  • - Autoimmune gastritis (AIG) is an autoimmune disorder that destroys stomach cells, leading to intrinsic factor deficiency and reduced stomach acid production, which primarily affects the antral mucosa and can increase the risk of certain cancers.
  • - The exact causes of AIG are not fully known, but it involves malfunctioning immune system responses that damage gastric tissue.
  • - This review highlights the current understanding of inflammation in AIG and discusses potential new biomarkers and treatment targets to better address this medical issue.
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  • - Surgeries for abdominal wall sarcomas often involve extensive resections that create complex defects, but using both porcine dermal xenografts and composite meshes can help with repair while reducing complications.
  • - A study involving 19 patients (average age 53.2 years) identified various types of sarcomas and demonstrated that surgical resections and reconstructions using these materials can be effective.
  • - After an average follow-up of 38 months, complications occurred in about 31.5% of patients, including wound issues and one death, but overall, the technique showed promising medium-term results.
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Lung endothelium resides at the interface between the circulation and the underlying tissue, where it senses biochemical and mechanical properties of both the blood as it flows through the vascular circuit and the vessel wall. The endothelium performs the bidirectional signaling between the blood and tissue compartments that is necessary to maintain homeostasis while physically separating both, facilitating a tightly regulated exchange of water, solutes, cells, and signals. Disruption in endothelial function contributes to vascular disease, which can manifest in discrete vascular locations along the artery-to-capillary-to-vein axis.

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Because of the low mutational burden and consequently, fewer potential neoantigens, children with acute myeloid leukemia (AML) are thought to have a T cell-depleted or 'cold' tumor microenvironment and may have a low likelihood of response to T cell-directed immunotherapies. Understanding the composition, phenotype, and spatial organization of T cells and other microenvironmental populations in the pediatric AML bone marrow (BM) is essential for informing future immunotherapeutic trials about targetable immune-evasion mechanisms specific to pediatric AML. Here, we conducted a multidimensional analysis of the tumor immune microenvironment in pediatric AML and non-leukemic controls.

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Respiratory syncytial virus (RSV) is a substantial cause of severe lower respiratory tract infections in infants, young children, older adults, and immunocompromised individuals. There is a vital need for effective therapeutics to prevent and/or treat severe RSV infection in these high-risk individuals. The development and pre-clinical testing of candidate RSV therapeutics could be accelerated by their evaluation in animals models that recapitulate bronchiolitis and bronchopneumonia; both hallmark features of severe RSV infection of humans.

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Background: Radioembolization with yttrium-90 (Y-90) is utilized to treat primary liver malignancies. The efficacy of this intra-arterial therapy in arterially hypoperfused tumors is not known.

Methods: We reviewed data of patients with primary liver tumors treated with Y-90 prescription doses of at least 150 Gy.

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  • AZD5991 is a drug being tested for safety and effectiveness in patients with relapsed or refractory blood cancers, both by itself and alongside another drug called venetoclax.
  • The clinical trial involved 61 patients receiving varying doses of AZD5991, while 17 patients took it in combination with venetoclax, focusing on determining safe dosage levels and any anti-cancer effects.
  • Results showed significant side effects such as diarrhea and nausea, with a low overall response rate to treatment, despite a few patients achieving partial or complete remission.
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  • Eating mushrooms is popular all over the world, but picking wild ones can be very dangerous if you accidentally eat a poisonous type.
  • Mushroom poisoning can be hard to diagnose and treat because its symptoms look like other sicknesses, and some poisonous mushrooms have incredibly strong toxins.
  • There are still many toxic mushrooms that scientists haven't studied yet, and this review talks about the chemistry and dangers of these toxins, as well as ways to better identify and treat mushroom poisoning.
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  • Cortactin is a key protein that helps maintain the barrier function of endothelial cells and may be involved in lung inflammatory disorders, but the regulation of its gene (CTTN) by inflammation and genetic variations is not well understood.
  • Laboratory experiments showed that exposure to inflammatory agents like LPS and TNF-α significantly boosts CTTN promoter activity, suggesting a strong link between inflammation and cortactin expression.
  • The findings indicate that variations in the CTTN gene and inflammatory stimuli can influence cortactin levels, potentially offering new targets for treating lung inflammation and related diseases.*
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The 22-hydroxy-23,24-bisnorchol-4-ene-3-one (4-HBC) is a C22 steroid synthon of pharmaceutical interest that can be produced as a lateral end-product of the catabolism of natural sterols (e.g., cholesterol or phytosterols).

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Posterior quadrant epilepsy surgery, involving the occipital lobe, parietal lobe, or the posterior border of the temporal lobe, accounts for a small percentage of focal resections for medically refractory epilepsy. Prior studies investigating seizure control from posterior quadrant epilepsy surgery are limited. In this study, a retrospective database of patients undergoing surgery for left sided posterior cortex epilepsy at a single large level 4 epilepsy center was analyzed between August 2008 to April 2021 in order to characterize seizure control outcomes.

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  • Large language models like ChatGPT-3.5 have potential for aiding self-directed medical learning, but their accuracy in specialized topics is under scrutiny.
  • A study with 23 medical students compared ChatGPT-3.5 to traditional internet searches regarding the Randleman criteria, revealing ChatGPT-3.5 was only accurate for 26.1% of responses, whereas internet searches were 100% accurate.
  • The findings suggest that ChatGPT-3.5 can mislead users, and students should critically evaluate its outputs while future efforts focus on improving AI accuracy and prompt effectiveness.
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Introduction: Stroke can have profound psychosocial health implications. These constructs are often overlooked and undertreated yet can be as devastating as the physical, functional, and cognitive consequences after stroke.

Aim: This scientific statement aims to evaluate 5 important aspects of psychosocial health (depression, stress, anxiety, fatigue, and quality of life) after a stroke to provide a framework for related nursing care across the poststroke continuum.

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Paracoccidioidomycosis (PCM) is an endemic fungal disease that occurs in Latin America and primarily affects humans. The disease has been rarely documented in non-human primates. This report details a disseminated and fatal case of PCM caused by Paracoccidioides brasiliensis in a western black-handed tamarin (Saguinus niger) under human care.

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Introduction: Heart failure (HF) is one of the leading causes of morbidity and mortality worldwide. This study aimed to assess the impact of sex on sociodemographic, clinical, and laboratory parameters in patients with HF who were included in the Colombian Heart Failure Registry (RECOLFACA).

Methods: This was a cross-sectional analytical research.

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Our study was to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition to investigate the underlying molecular mechanisms. Aged male (23-32 months old) and female (27-28 months old) C57BL/6J mice were classified as non-, probable-, or sarcopenic based on assessments of grip strength, muscle mass, and treadmill running time, using 2 SDs below the mean of their young counterparts as cutoff points. A 9%-22% prevalence of sarcopenia was identified in 23-26 month-old male mice, with more severe age-related declines in muscle function than mass.

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Introduction: Federal food safety net programs, like the Supplemental Nutrition Assistance Program (SNAP), may not reach vulnerable populations like rural residents, immigrants, and Latinx individuals. Because these groups are overrepresented among the farm workforce, exploring SNAP utilization among farm communities may clarify the role it plays in alleviating food insecurity.

Methods: In-depth interviews were conducted with 31 farmworkers and farm owners.

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Article Synopsis
  • Prognostic biomarkers are important for understanding sporadic desmoid tumors (DT) due to their unpredictable nature; this study focused on gene expression differences between DTs located in the thoracic versus abdominal wall.
  • A retrospective analysis of 197 sporadic DT patients showed significant relationships between relapse-free survival (RFS) and factors like tumor size, location, and specific gene mutations, notably the CTNNB1 T41A and S45F mutations.
  • Results suggest that tumors in the abdominal wall have a better prognosis compared to extra-abdominal locations, with distinct gene expression profiles influencing cancer pathways related to their behavior and outcomes.
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Some Basidiomycete fungi are important plant pathogens, and certain species have been associated with the grapevine trunk disease esca. We present the genomes of 4 species associated with esca: Fomitiporia mediterranea, Fomitiporia polymorpha, Tropicoporus texanus, and Inonotus vitis. We generated high-quality phased genome assemblies using long-read sequencing.

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The HIV reservoir is more dynamic than previously thought with around 70% of the latent reservoir originating from viruses circulating within 1 year of the initiation of antiretroviral therapy (ART). In an model system of HIV latency, it was reported that early exposure to class I histone deacetylase (HDAC) inhibitors might prevent these more recently infected cells from entering a state of stable viral latency. This finding raises the possibility that co-administration of HDAC inhibitors at the time of ART initiation may prevent the establishment of much of the HIV reservoir.

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Objectives: Many barriers to implementation of developmental screening in primary care exist, especially for children from under-resourced communities. Developmental screening is vital to early detection of developmental delay and autism spectrum disorder, and early intervention (EI) referral. This study sought to examine whether implementation of a standardized clinical workflow using electronic screening tools improved both rates of developmental screening, and the number of children identified at risk for developmental delay, in a federally qualified health center (FQHC).

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Assessing the allostatic load of workers in the context of COVID -19 is of vital importance to elucidate the physiological responses to social and work stress. This is an integrative review of the literature including seven established steps: 1) identification of the topic and the guiding question; 2) definition of MeSH terms and search equations; 3) search in databases following defined criteria; 4) data collection according to inclusion criteria; 5) evaluation of the studies included in the integrative review; 6) discussion of results; and 7) presentation of the review/synthesis of knowledge. Seventeen studies were included, of which 15 were cross-sectional observational studies and two were longitudinal studies.

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  • Endometrial cancer (EC) is closely linked to obesity, particularly affecting young women, and identifying it early can improve treatment options, especially for those with severe obesity undergoing metabolic/bariatric surgery.
  • A screening program using a modified questionnaire, called Modified SAMANTA, was implemented to identify women with abnormal or postmenopausal uterine bleeding (APUB) before their surgery to check for possible underlying endometrial issues.
  • Over a study period from March 2021 to May 2023, nearly half of the 1371 women screened were found to have APUB, with higher prevalence linked to factors like increased BMI and certain racial demographics, highlighting the need for careful monitoring in these patients.*
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  • The Universidad de Antioquia's LivingLab developed a telehealth mental health programme during the COVID-19 pandemic to provide care and evaluate patient satisfaction.
  • From March 2020 to August 2021, the programme treated over 10,000 patients, with the majority diagnosed with depressive, anxiety, and psychotic disorders, and conducted more than 6,000 telehealth visits.
  • Patient satisfaction was high, with over 93% indicating they would recommend the service, suggesting the programme’s effectiveness and potential for broader adoption in mental health care.
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