Publications by authors named "Garbo Young Nilsson"
Biomolecules
December 2023
Article Synopsis
- Raf-1 is a multifunctional kinase that regulates important cellular processes, and its activity is controlled by various mechanisms, including interactions with regulatory proteins and phosphorylation.
- The study demonstrates that PHI-1, an inhibitor of protein phosphatase-1 (PP1), is crucial for maintaining Raf-1 levels in cells; knocking down PHI-1 leads to increased cell proliferation and reduced apoptosis by enhancing Raf-1 expression and ERK1/2 phosphorylation.
- Ectopic expression of PHI-1 lowers Raf-1 levels, and inhibiting PP1 mimics PHI-1's effects, indicating that the PHI-1-PP1 axis plays a key role in regulating Raf-1 stability and survival
