Publications by authors named "Gaozhong Yi"
[miR-21 promotes pulmonary fibrosis in rats via down-regulating the expression of ADAMTS-1].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
December 2016
Objective To observe the effect of miR-21 on bleomycin-induced pulmonary fibrosis in rats, and explore the related mechanism. Methods Peripheral blood was collected from idiopathic pulmonary fibrosis (IPF) patients (n=20) and healthy adults (n=20). Fluorescence quantitative real-time PCR was then used to measure miR-21 expression.
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- A recent study assessed the effects of suramin on lung adenocarcinoma in mice, finding it could inhibit tumor growth and metastasis.
- Suramin was compared with cisplatin in various treatment groups, showing significant tumor growth inhibition rates (34.9% for DDP, 23.8% for suramin, and 57.3% for the combination).
- Results indicated that suramin, alone or combined with cisplatin, reduced lung metastasis rates and lower protein expression levels of EGFR and P-selectin compared to control and cisplatin-only groups.