Ferulic acid ameliorates renal injury via improving autophagy to inhibit inflammation in diabetic nephropathy mice.

Diabetic nephropathy (DN) is one of the most serious microvascular complications following diabetes mellitus (DM). Ferulic acid (FA), a phenolic acid widely found in plants, has multiple pharmacological effects such as anti-oxidation, anti-inflammation and anti-tumor. However, the current research on FA in the field of DN is insufficient.

Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats.

Objective: To investigate whether total triterpene acids (TTAs), isolated from Cornus Fructus, attenuates renal function by reducing oxidative stress and down-regulating the expression of transforming growth factor β1 (TGF-β1).

Methods: Diabetes was induced by an injection of streptozotocin (40 mg/kg intravenously). Thirty rats were randomly divided into three groups: control group, diabetic model group and TTAs treatment group (50 mg/kg, intragastrically) administrated for 8 weeks from 5th to 12th week.

[Protective effect of total flavonoids of herba epimedii on testis degeneration in diabetic mice].

Objective: To observe the protective effects and investigate the possible mechanism of total flavonoids of herba epimedii (TFE) on diabetic testopathy in mice.

Methods: Diabetic animal model was produced by a single injection of alloxan ( 70 mg/kg, i.v.

[Amelioration of icariin for the epididymis impairment induced by streptozocin (STZ) in rats].

Objective: To investigate the effects of icariin on the streptozocin (STZ)-induced epididymis impair in rats.

Methods: The epididymis impair was induced by injection of streptozocin at dosage of 60 mg/kg ip in SD rats. Animals were randomly divided into six groups (n = 14): normal control, model group, three icariin treated group with different dosages (P.