Nuclear protein NOP2 serves as a poor-prognosis predictor of LUAD and aggravates the malignancy of lung adenocarcinoma cells.

Recent studies have shown that NOP2, a nucleolar protein, is up-regulated in various cancers, suggesting a potential link to tumor aggressiveness and unfavorable outcomes. This study examines NOP2's role in lung adenocarcinoma (LUAD), a context where its implications remain unclear. Utilizing bioinformatics, we assessed 513 LUAD and 59 normal tissue samples from The Cancer Genome Atlas (TCGA) to explore NOP2's diagnostic and prognostic significance in LUAD.

Serum vitamin D levels and Sjogren's syndrome: bi-directional Mendelian randomization analysis.

Background: Based on the results of existing observational studies, it can be found that the association between serum vitamin D levels and the risk of Sjogren's syndrome (SS) in humans is still controversial. Based on this situation, this study aimed to assess the causal relationship between serum vitamin D levels and SS by using the Mendelian randomization (MR) approach.

Methods: In this study, genome-wide association studies (GWAS) summary statistics on serum vitamin D levels [sample size = 417,580 (UK Biobank)] and SS [sample size = 416,757 (cases = 2495, controls = 414,262) (FinnGen)] were used.

Development and validation of a combined ferroptosis and immune prognostic signature for lung adenocarcinoma.

Background: Studies have shown that the regulation of ferroptosis could be a new approach to cancer treatment and abnormal ferroptosis is closely associated with a dysregulated immune response. However, a combined signature with ferroptosis-related genes (FRGs) and immune-related genes (IRGs) is necessary to be constructed for predicting prognoses and guiding individualized precision therapy of lung adenocarcinoma (LUAD) patients.

Methods: In this study, based on the Cancer Genome Atlas (TCGA) cohort, prognosis-related FRGs and IRGs were first identified and incorporated into the Least Absolute Shrinkage and Selection Operator (LASSO)-Cox regression model to generate a combined signature of ferroptosis- and immune-related genes (CSFI) values to predict the overall survivals (OSs) of LUAD patients.

Identification and validation of a genomic mutation signature as a predictor for immunotherapy in NSCLC.

Currently, the benefits of immune checkpoint inhibitor (ICI) therapy prediction via emerging biomarkers have been identified, and the association between genomic mutation signatures (GMS) and immunotherapy benefits has been widely recognized as well. However, the evidence about non-small cell lung cancer (NSCLC) remains limited. We analyzed 310 immunotherapy patients with NSCLC from the Memorial Sloan Kettering Cancer Center (MSKCC) cohort.

Epidemiological trends and incidence prediction of lung cancer in China based on the Global Burden of Disease study 2019.

Lung cancer remains the most common malignancy in China. This study aims to provide scientific support for the prevention and treatment of lung cancer by analyzing the epidemiological trends of lung cancer in China from 1990 to 2019. Based on the global health exchange database (GHDx), joinpoint and age-period-cohort analyses were performed to explore the trend of lung cancer incidence and mortality rates from 1990 to 2019.

The Molecular Epidemiological and Immunological Characteristics of HIV-1 CRF01_AE/B Recombinants in Nanjing, China.

Human immunodeficiency virus-type 1 (HIV-1) CRF01_AE/B recombinants are newly emerging strains that are spreading rapidly in Southern and Eastern China. This study aimed to elucidate the molecular epidemiological characteristics of HIV-1 CRF01_AE/B recombinants in Nanjing and to explore the impact of these novel strains on the immunological status. A total of 1,013 blood samples from newly diagnosed HIV-1-infected patients were collected in Nanjing from 2015 to 2019, among which 958 partial Pol sequences were sequenced successfully.

School Bullying Victimization and Associated Factors Among School-Aged Adolescents in China.

There has been a significant amount of research on correlates of bullying victimization, but most prior studies are descriptive and do not distinguish between different types of bullying. The current study used a case-control study design to explore factors related to different types of bullying victimization, including physical, relational, verbal, sexual, property, and poly-bullying victimization. This study was conducted in a southern city in China, including 3054 cases who self-reported being victims of school bullying and 3054 controls who reported not being involved in any school bullying in the past 12 months.

Unintentional injuries and risk behaviours of internal migrant children in southern China: A cross-sectional study.

The purpose of this study was to estimate the prevalence of unintentional injuries and to identify factors mediating the risk of unintentional injuries among internal migrant children in southern China using self-reported data collected between April 2016 and March 2017. Logistic regression models were used to identify significant risk factors for unintentional injuries among the internal migrant children. The prevalence of self-reported unintentional injuries among internal migrant children in this study was 19.

Revised road traffic safety law and years of life lost due to traffic deaths in China, 2002-2019.

Legal intervention is a powerful tool to reduce road traffic injuries (RTIs). China amended the Road Traffic Safety Law in 2011, but the impact of amended law on traffic crash deaths is still unknown. In this study, we conducted an interrupted time series analysis and examined years of life lost (YLLs) per 100,000 population as the assessment indicator to evaluate the association of road traffic safety law and traffic crash mortality.

The Short-term Effects of Temperature on Infectious Diarrhea among Children under 5 Years Old in Jiangsu, China: A Time-series Study (2015-2019).

The association between meteorological factors and infectious diarrhea has been widely studied in many countries. However, investigation among children under 5 years old in Jiangsu, China remains quite limited. Data including infectious diarrhea cases among children under five years old and daily meteorological indexes in Jiangsu, China from 2015 to 2019 were collected.

The association of sex-biased ATRX mutation in female gastric cancer patients with enhanced immunotherapy-related anticancer immunity.

Background: Genetic alterations have been proven to be the promising biomarkers for ICI response. However, sex biases in genetic alterations have been often ignored in the field of immunotherapy, which might specially influence the anticancer immunity and immunotherapy efficacy in male or female patients. Here, we have systematically evaluated the effect of the sex biases in somatic mutation of gastric cancer (GC) patients on the anticancer immunity and clinical benefit to immunotherapy.

Risk Factors Associated With School Bullying Behaviors: A Chinese Adolescents Case-Control Study, 2019.

This research aimed to identify risk factors including individual characteristics and environment circumstances related to different types of school bullying (physical, relational, verbal, sexual, and possession bullying) among middle school students in China. Cases were the respondents reporting perpetrating bullying behaviors three or more times in the past year. One control was selected for each case from those participants who were not involved in school bullying in the past 12 months.

Effectiveness of implementing the criminal administrative punishment law of drunk driving in China: An interrupted time series analysis, 2004-2017.

In 2011, a more severe drunk driving law was implemented in China, which criminalized driving under the influence of alcohol for the first time and increased penalties for drunk driving. The present study aimed to assess effectiveness of the drunk driving law in China in reducing traffic crashes, injuries, and mortality. Data used in this study was obtained from the Traffic Management Bureau of the Ministry of Public Security of the People's Republic of China.

Forecasting deaths of road traffic injuries in China using an artificial neural network.

This study was conducted to estimate road traffic deaths and to forecast short-term road traffic deaths in China using the Elman recurrent neural network (ERNN) model. An ERNN model was developed using reported police data of road traffic deaths in China from 2000 to 2017. Different numbers of neurons of the hidden layer were tested and different combinations of subgroup datasets have been used to develop the optimal ERNN model after normalization.

Riding behavior and electric bike traffic crashes: A Chinese case-control study.

The present case-control study sought to explore at-risk riding behaviors associated with e-bike related traffic crashes among e-bike riders in China. Cases were recruited from residents aged 16 years and over in communities which stated "selected e-bikes as travel tools and experienced traffic crashes in the last year". Two controls for each case were randomly selected from a population of e-bike riders who had not experienced a traffic crash in the past year.

Driving anger among motor vehicle drivers in China: A cross-sectional survey.

Driving anger is a common emotion while driving and has been associated with traffic crashes. This study aimed to investigate situations that increase driving anger among Chinese drivers. A cross-sectional study was conducted among 3,101 drivers in southern China.

Impact of probable interaction of low temperature and ambient fine particulate matter on the function of rats alveolar macrophages.

The present study aimed to explore the probable interaction of low temperature and ambient fine particulate matter (PM) on rat alveolar macrophages (AMs). AMs were separated from rat BALF and exposed to PM (0, 25, 50, 100μg/ml) under different temperature (18, 24, 30, 37°C) for 8h. Results indicated that viability and phagocytosis function of AMs decreased with the decline of temperature and the rise of PM dose, and the strongest toxicity was shown in the highest PM (100μg/ml) exposure group at 18°C.

[Impact of different temperatures and ambient PM2.5 on the cytotoxicity and cytophagocytic function of alveolar macrophages of rat].

Objective: To investigate the interactive effects of different temperatures and ambient PM2.5 on the rat alveolar macrophages.

Methods: The rat alveolar macrophages were collected.