Publications by authors named "Gaopeng Li"

Cholangiocarcinoma (CCA), a malignant tumor, is typically challenging to detect early and often results in a poor prognosis. In recent years, research interest has grown in the potential application of immunotherapy for CCA treatment. T cells, as a crucial component of the immune system, play a significant role in immune surveillance and therapy for cholangiocarcinoma.

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Introduction: Atrial fibrillation (AF) significantly detracts from health-related quality of life (HRQoL). Despite the promotion of exercise interventions for managing AF, the effectiveness of different exercise modalities remains to be clearly defined. This systematic review and network meta-analysis aims to evaluate the comparative effectiveness of various modes of exercise interventions on HRQoL in AF patients.

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Cholangiocarcinoma is the second most common primary liver cancer, and its global incidence has increased in recent years. Radical surgical resection and systemic chemotherapy have traditionally been the standard treatment options. However, the complexity of cholangiocarcinoma subtypes often presents a challenge for early diagnosis.

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Background: Elevated evidence suggests that KIF20A plays an important role in hepatocellular carcinoma (HCC) progression. Nevertheless, the underlying mechanism by which KIF20A promotes HCC cell growth are not well understood.

Methods: Using TCGA-LIHC RNAseq and GEO datasets, we assessed the KIF20A expression and patient survival in HCC and hepatitis B virus (HBV)-related HCC.

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Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) and other myeloid cells with antigen presenting and cancer cell killing capacities is an attractive but not fully exploited approach. Here, we show that PIKFYVE is a shared gene target of clinically relevant protein kinase inhibitors and high expression of this gene in DCs is associated with poor patient response to immune checkpoint blockade (ICB) therapy.

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Background & Aims: Inflammatory bowel disease is associated with carcinogenesis, which limits the prognosis of the patients. The local expression of proteinases and proteinase-activated receptor 1 (PAR) increases in inflammatory bowel disease. The present study investigated the therapeutic effects of PAR antagonism on colitis-associated carcinogenesis.

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Photodynamic therapy (PDT) is a non-invasive treatment method that has garnered significant attention in recent years. Nanoparticle-based drug delivery systems can achieve targeted drug release, thereby significantly reducing side effects and enhancing therapeutic efficacy. In this study, a covalent organic framework (COF) with an approximately spherical structure connected by azo bonds was synthesized.

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Hepatocellular carcinoma (HCC) is the sixth most common cancer globally and the primary cause of death in cancer cases, with significant public health concern worldwide. Despite the overall decline in the incidence and mortality rates of HCC in recent years in recent years, the emergence of metabolic liver disease-related HCC is causing heightened concern, especially in countries like the United States, the United Kingdom, and P.R.

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Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood whether and how post-translational modifications (PTMs) intrinsically affect the phenotype and function of TAMs. Here, we reveal that peptidylarginine deiminase 4 (PAD4) exhibits the highest expression among common PTM enzymes in TAMs and negatively correlates with the clinical response to immune checkpoint blockade.

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The modern armamentarium for cancer treatment includes immunotherapy and targeted therapy, such as protein kinase inhibitors. However, the mechanisms that allow cancer-targeting drugs to effectively mobilize dendritic cells (DCs) and affect immunotherapy are poorly understood. Here, we report that among shared gene targets of clinically relevant protein kinase inhibitors, high expression was least predictive of complete response in patients who received immune checkpoint blockade (ICB).

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There is an urgent need for wearable sensors that continuously monitor human physiological conditions in real time. Herein, an ESM-PDA@rGO-based flexible wearable temperature sensor was successfully constructed by integrating an eggshell membrane (ESM) with reduced graphene oxide (rGO) through dopamine (DA) polymerization. Depending on the "bridge effect" of diversified polydopamine (PDA) chains, on the one hand, a staggered arrangement of PDA-rGO frameworks and a lot of conductive pathways were produced and acted as an active layer.

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Background: As a three-dimensional network involving glycosaminoglycans (GAGs), proteoglycans (PGs) and other glycoproteins, the role of extracellular matrix (ECM) in tumorigenesis is well revealed. Abnormal glycosylation in liver cancer is correlated with tumorigenesis and chemoresistance. However, the role of galactosyltransferase in HCC (hepatocellular carcinoma) is largely unknown.

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Article Synopsis
  • * A new MALDI matrix, 2,5-dihydroxyterephthalic acid (DHT), has been developed to enhance the detection and imaging of amino acids in biological samples, showing superior performance compared to standard matrices like DHB and CHCA.
  • * Using DHT, researchers successfully detected all 20 protein amino acids in human serum and in oyster tissue for the first time, demonstrating its effectiveness in improving amino acid analysis with MALDI mass spectrometry.
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Various naphthalenediimide (NDI) based electron donor-acceptor coordination polymers (D-A CPs) have been constructed and used to explore charge transfer (CT) and electron transfer (ET) behaviors. Up to now, significant progress has been made in the interface contact and electron donor-acceptor ability matching mechanism, while the electronic density effect of the electron donors on the CT and ET behaviors is still not known. Herein, two NDI-based D-A CPs, [Cd(HNDI)(IPA)(HO)] (1) and [Cd(HNDI)(IPA-OH)(HO)] (2), are constructed using an NDI-based ligand and two aromatic carboxylic acid ligands (HNDI = 2,7-bis(3,5-dimethyl) dipyrazol-1,4,5,8-naphthalene tetracarboxydiimide, HIPA = isophthalic acid; and HIPA-OH = 5-hydroxyisophthalic acid).

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By the combination of ,-bis(carboxymethyl)-pyromellitic diimide (HCMPMD, ) and zinc ions, a novel PMD-based coordination polymer (CP), [Zn(CMPMD)(DMF)]·0.5DMF () (DMF = ,-dimethylformamide), has been prepared and characterized. and exhibit completely different photochromic properties, which are mainly reflected in the photoresponsive rate (5 s for vs 1 s for ) and coloration contrast (from colorless to light green for vs green for ).

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Three novel naphthalenediimide-based (NDI-based) coordination polymers (CPs), namely [Cd(3-PMNDI)(2,2'-BPDC)] (1), [Cd(3-PMNDI)(4,4'-BPDC)(HO)]·DMF (2) and [Cd(3-PMNDI)(4,4'-SDC)] (3) (2,2'-HBPDC = 2,2'-biphenyldicarboxylic acid, 4,4'-HBPDC = 4,4'-biphenyldicarboxylic acid, 4,4'-HSDC = 4,4'-stilbenedicarboxylic acid, 3-PMNDI = ,'-bis(3-pyridylmethyl)-1,4,5,8-naphthalenediimide, and DMF = ,'-dimethylformamide), have been designed and synthesized here from electron-deficient PMNDI (electron acceptors, EAs) and electron-rich aromatic carboxylic acids (electron donors, EDs) in the presence of cadmium ions. The introduction of aromatic carboxylic acids with different sizes and conjugation degrees leads to the generation of a two-dimensional (2D) layer in 1, a two-fold interpenetrated three-dimensional (3D) network in 2 and an eight-fold interpenetrated 3D framework in 3. Furthermore, the use of distinct electron-donating aromatic carboxylic acids and the consequent different numbers and strengths of lone pair-π and π-π interactions in the interfacial contacts of EDs/EAs give rise to distinct intermolecular charge transfer (ICT) and initial colors of the three CPs, and consequently cause different photoinduced intermolecular electron transfer (PIET) and distinguishing photo-responsive behaviors (weak photochromic performance for 1, excellent photochromic properties for 2 and non-photochromism for 3).

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Lung cancer is the leading cause of cancer-related deaths worldwide. Combination of drugs targeting independent signaling pathways would effectively block the proliferation of cancer cells with lower concentrations and stronger synergy effects. Dasatinib, a multi-targeted protein tyrosine kinase inhibitor targeting BCR-ABL and kinases of SRC family, has been successfully applied in the treatment of chronic myeloid leukemia (CML).

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Article Synopsis
  • The study explored the use of polyacrylamide gel (PAAG) as a new embedding medium for improving the maintenance of biological tissues during the sectioning process for mass spectrometry imaging.
  • PAAG was compared to other common embedding materials (agarose, gelatin, OCT, and ice) in terms of tissue morphology maintenance and efficiency in ionizing metabolites.
  • The results indicated that PAAG outperformed these traditional media, offering advantages such as a one-step operation, better morphology preservation, reduced interference, and enhanced metabolite ion signals, suggesting its potential as the new standard for metabolite imaging.
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Immune checkpoint blockade (ICB) can produce durable responses against cancer. We and others have found that a subset of patients experiences paradoxical rapid cancer progression during immunotherapy. It is poorly understood how tumors can accelerate their progression during ICB.

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Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a powerful approach that has been widely used for detection of various endogenous compounds in tissues. However, there are still challenges with analysis of proteins using MALDI-MSI due to the ion suppression effects of small molecules in tissue sections. Therefore, tissue-washing steps are crucial for protein MALDI tissue imaging to remove these interfering molecules.

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Two novel naphthalene diimide (NDI) coordination polymers (CPs), [Cd(NicNDI)(4,4'-SBC)] (1) and [Cd(NicNDI)(2,2'-BPC)] (2) (NicNDI = (3-pyridylacylamino)-1,4,5,8-naphthalene diimide, 4,4'-SBC = 4,4'-stilbene dicarboxylic acid, 2,2'-BPC = 2,2'-biphenyl dicarboxylic acid), were designed and prepared by the combination of electron-deficient NicNDI and electron-rich aromatic carboxylic acid ligands in the presence of cadmium ions. The usage of aromatic carboxylic acid ligands with different conjugation degrees, sizes, shapes and charge densities leads to the generation of distinct interpenetrated three-dimensional (3D) frameworks. Interestingly, photochromism of 1 and weak photoactivity of 2 should be attributed to the introduction of different auxiliary ligands and consequently the formation of distinct interfacial contacts of electron donors (EDs)/electron acceptors (EAs) ( = 3.

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Hepatitis B virus (HBV) infection is a main carcinogenic factor of hepatocellular carcinoma (HCC). TPX2 microtubule nucleation factor is recently recommended as a novel prognostic biomarker in HBV-infected HCC tissues. This study aimed to explore a TPX2-related ceRNA regulatory network in HBV-infected HCC and the potential impact on HCC prognosis.

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Various arylenediimides (ADIs) have been applied to construct photoresponsive coordination polymers (CPs), while the size effect of ADI π-conjugate systems on the photoresponsive behaviors in CPs has been overlooked in the past few years. Herein, we emphasize the size effect of ADI π-conjugate systems on photoinduced electron transfer (ET) in CPs, taking two Eu-based CPs, [Eu(HBINDI)(BINDI)(HO)]·NH(CH)·8HO () and [Eu(BIPMDI)(DMF)(NO)]·HO·2DMF () [HBINDI = ,'-bis(5-isophthalic acid)naphthalenediimide; HBIPMDI = ,'-bis(5-isophthalic acid)pyromellitic diimide; DMF = ,-dimethylformamide], as a case. Both and display ET-based photochromic behaviors with distinct photoresponsive rates and coloration contrast, which can contribute to the size effect of diimide cores on the interfacial contacts of electron donors/acceptors.

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