Publications by authors named "Gaonkar M"
Background: The Predicting Risk of CVD Events (PREVENT) equations were developed to address limitations of the Pooled Cohort Equations (PCEs) in predicting atherosclerotic cardiovascular disease (ASCVD) risk. The comparative effectiveness of the PREVENT equations versus the PCEs in predicting mortality risk remains unknown.
Objectives: The purpose of this study was to compare the risk discrimination value of the PREVENT equations with the PCEs for predicting mortality.
The Pooled Cohort Equations (PCEs), developed by the American Heart Association (AHA) and American College of Cardiology, have been widely used since 2013 to estimate 10-year atherosclerotic cardiovascular disease (ASCVD) risk and guide statin therapy. Recently, the AHA introduced the Predicting Risk of CVD EVENTs (PREVENT) equations to improve ASCVD risk estimation. However, the effect of using PREVENT instead of PCEs on risk classification and statin eligibility remains unclear.
View Article and Find Full Text PDFObjective: To evaluate sex-associated differences in the short- and long-term outcomes of patients with hypertrophic cardiomyopathy (HCM) undergoing septal myectomy and alcohol septal ablation.
Methods: This retrospective cohort study used electronic health record data from the TriNetX research database. International Classification of Diseases, Ninth Revision and Tenth Revision diagnosis and procedure codes were used to identify patients with HCM who underwent septal myectomy and alcohol septal ablation in the United States between January 2002 and March 2023.
Background: Nearly 3% to 4% of Black individuals in the United States carry the transthyretin V142I variant, which increases their risk of heart failure. However, the role of cardiovascular (CV) risk factors (RFs) in influencing the risk of clinical outcomes among V142I variant carriers is unknown.
Objectives: This study aimed to assess the impact of CV RFs on the risk of heart failure in V142I carriers.
Background: Septal myectomy and alcohol septal ablation (ASA) are septal reduction therapies for patients with symptomatic obstructive hypertrophic cardiomyopathy. Operator and hospital volume may influence outcomes, but contemporary data on this relationship are limited.
Methods And Results: This retrospective cohort study used data from the Vizient Clinical Data Base (2016-2022).
Article Synopsis
- Carriers of the high-proportion spliced-in (hiPSI) titin truncating variant (TTNtv) are at an increased risk of atrial fibrillation and heart failure compared to noncarriers, particularly influenced by their cardiovascular risk levels.
- The study analyzes data from UK Biobank participants without existing cardiovascular diseases and classifies them by their hiPSI TTNtv carrier status and cardiovascular risk (low, intermediate, high).
- Findings suggest that having a favorable cardiovascular risk profile can reduce the risk of serious health outcomes in hiPSI TTNtv carriers, with low-risk carriers showing a significantly lower hazard ratio compared to high-risk carriers.
Article Synopsis
- This study aimed to evaluate how a systolic blood pressure polygenic risk score (SBP-PRS) influences the decision to start antihypertensive treatment and compare its effectiveness to coronary artery calcium (CAC) scores in predicting heart-related issues.
- Researchers analyzed data from 5,267 individuals over a 10-year period, focusing on those with high and low SBP-PRS and CAC scores, revealing that both genetic factors and CAC scores can help personalize hypertension treatment plans.
- The findings indicated that while genetic information offers some insight for treatment initiation, CAC scores provide greater predictive value for cardiovascular events, highlighting the importance of personalized medicine in managing hypertension.
Article Synopsis
- * It found that transthyretin levels vary by gender, body mass index, and other health markers; specifically, non-carriers of the V142I variant had higher levels than carriers.
- * Lower levels of transthyretin are linked to increased risk of heart failure and overall mortality, suggesting that those with the V142I variant are particularly vulnerable.
Article Synopsis
- In 2022, the Life's Essential 8 (LE8) score replaced the Life's Simple 7 (LS7) score for assessing cardiovascular health, and this study explores their risk prediction capabilities for mortality.
- The research analyzed data from over 21,000 individuals to compare the risk prediction values of LE8, LS7, and pooled cohort equations (PCE) specifically for those aged 40 to 79.
- Results showed that LE8 and LS7 scores had similar effectiveness in predicting all-cause and cardiovascular mortality, but the PCE outperformed both in risk prediction for the older age group.
Article Synopsis
- The study aimed to assess trends in lipid levels, cholesterol awareness, and statin use among people with severe dyslipidemia (high LDL-C levels ≥190 mg/dL) from 2011 to 2020.
- Results showed that the prevalence of severe dyslipidemia remained stable at 5.4%, with LDL-C and triglyceride levels not significantly changing during this period.
- Awareness of hypercholesterolemia and cholesterol evaluations were steady at around 50% and 75%, respectively, while only about 34% of individuals with severe dyslipidemia used statins, possibly explaining the lack of change in LDL-C levels.
Article Synopsis
- Natriuretic peptides (NPs) are important hormones for heart and metabolic health, but their normal levels in healthy Americans and NP deficiency prevalence are not well understood.
- * This study used data from the National Health and Nutrition Examination Survey to determine normal levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and how common NP deficiency is in the U.S.
- * Results showed significant differences in NT-proBNP levels by age, sex, and ethnicity, with an estimated 9.1 million Americans experiencing NP deficiency, which is linked to higher risks of various cardiometabolic diseases.
Article Synopsis
- * Many existing studies on water quality in India have limitations due to irrelevant data and a focus on metrics like biological and chemical oxygen demand, neglecting the importance of dissolved oxygen (DO) in assessing pollution levels.
- * This work introduces a wavelet genetic programming (WGP) model designed to evaluate water quality in 13 rivers in Uttar Pradesh, improving accuracy by eliminating irrelevant data and highlighting DO as a key quality factor, and using innovative techniques for data preprocessing.
Article Synopsis
- The study examines cardiovascular health (CVH) in Asian American individuals, leveraging oversampling in the NHANES from 2011 to March 2020.
- The Life's Essential 8 (LE8) score was analyzed, revealing a decline in overall CVH, particularly among foreign-born individuals.
- It was found that while foreign-born individuals showed higher odds of ideal smoking and dietary habits, they had lower odds of achieving ideal physical activity and cholesterol levels compared to US-born individuals.
Purpose: To evaluate the effect of scleral crosslinking (SXL) on slowing experimental progressive myopia in tree shrew eyes using sub-Tenon's injections of genipin (GEN) at different concentrations and number of injections.
Methods: Three or five sub-Tenon's injections of GEN at 0 mM (sham), 10 mM, or 20 mM were performed in one eye every other day starting at 18 days of visual experience. Form deprivation (FD) myopia was induced in the injected eye between 24 and 35 days of visual experience; the fellow eye served as control.
Purpose: To evaluate the anesthetic effect of single-point low-volume peribulbar anesthesia supplemented by topical anesthesia.
Setting: Private ambulatory ophthalmic practice.
Methods: Five hundred consecutive patients received 4 cc of lidocaine 2% with 200 units hyaluronidase as 1-point peribulbar anesthesia.