Publications by authors named "Gaon Jung"
Article Synopsis
- The study explored the Eustachian tube's role in the spread of injected nanoparticles and gentamicin in rats after ear injection.
- The experiment involved three groups of Sprague-Dawley rats with varying substances injected, and imaging was used to monitor the distribution of these particles.
- Results indicated that nanoparticles could spread to the opposite ear, suggesting that the Eustachian tube may facilitate this movement, which raises concerns for controlling studies on drug delivery in the inner ear.
Noise-induced hearing loss (NIHL) is primarily caused by damage to cochlear hair cells, associated with synaptopathy. The novel cell-penetrating peptide GV1001, an antitumor agent, also has antioxidant and anti-inflammatory effects, and is otoprotective in a murine model of kanamycin-induced ototoxicity. Here, we explored whether GV1001 attenuated NIHL, and the underlying mechanism at play.
View Article and Find Full Text PDFHypothesis: We tested whether GV1001 has any ototoxic side effects at different doses and whether it protects hearing in an aminoglycoside-induced ototoxicity mouse model.
Background: GV1001, a novel peptide vaccine currently being examined in a Phase 3 clinical trial to treat pancreatic cancer, also has anti-inflammatory and antioxidant effects.
Methods: In the first experiment, C57/BL6 mice were injected with GV1001 preparations at concentrations of 0.
Novel Peptide Vaccine GV1001 Rescues Hearing in Kanamycin/Furosemide-Treated Mice.
Front Cell Neurosci
January 2018
The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant and anti-inflammatory effects. It has shown a protective effect on a kanamycin (KM)-induced ototoxicity mouse model. In the present study, we administered GV1001 at different time points after inducing hair cell damage, and examined if it rescues hair cell loss and restores hearing.
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