Synopsis of recent research by authors named "Gaojun Chen"
- Gaojun Chen's research primarily focuses on understanding the molecular mechanisms involved in stress-induced hypertension (SIH) and its regulation via various microRNA and RNA profiles, particularly in the rostral ventrolateral medulla (RVLM), a critical area for controlling sympathetic activity and blood pressure regulation.
- Recent findings highlight the involvement of different RNA molecules, such as microRNAs (e.g., miR-193b-3p, miR-335), circular RNAs, and long non-coding RNAs, in modulating neuronal excitability and mitochondrial function within the RVLM, which contributes to the development of hypertension under stress conditions.
- Chen's work also explores the role of inflammatory mediators, such as Caspase-1 and TNF-α, in adipogenesis and mitochondrial dysfunction linked to obesity and metabolic disorders, revealing potential pathways for therapeutic intervention in hypertension and related diseases.
