Publications by authors named "Gaojian He"
Article Synopsis
- Baicalein shows potential as an anti-tumor agent against MCF-7 breast cancer cells by promoting cell death (apoptosis) and reducing cell viability in a dose-dependent manner.
- The study investigates how baicalein affects the Wnt3α/β-catenin signaling pathway, finding that it can counteract increased cell viability and apoptosis caused by the activation or inhibition of this pathway.
- Results indicate that baicalein also upregulates the protein Nischarin, suggesting it could be a promising target for future breast cancer therapies.
Article Synopsis
- L3MBTL2 is a protein linked to cancer that inhibits a tumor suppressor called Nischarin (NISCH) in breast cancer, though its exact functions were previously unclear.
- Knockdown of L3MBTL2 leads to less monoubiquitination of histone H2A, allowing for higher NISCH expression, which in turn decreases cancer cell growth, invasion, and the occurrence of epithelial-mesenchymal transition (EMT).
- The study finds that UBTF activates L3MBTL2, and silencing UBTF slows tumor growth, while reducing NISCH can reverse these positive effects of UBTF, showcasing a complex interaction between these proteins in breast cancer progression.
Baicalein has been implicated in the chemotherapy overcoming triple-negative breast cancer (TNBC). However, many unanswered questions remain regarding its role in treating TNBC. Here, we sought to demonstrate the molecular pathway mediated by baicalein in TNBC.
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