Construction of silver-coated high translucent zirconia implanting abutment material and its property of antibacterial.

High translucent zirconia (HTZ) has excellent mechanical properties, biocompatibility, and good semi-translucency making it an ideal material for aesthetic anterior dental implant abutments without antibacterial properties. In the oral environment, the surface of the abutment material is susceptible to microbial adhesion and biofilm formation, which can lead to infection or peri-implantitis and even implant failure. This study aims to promote the formation of a biological seal at the implant-soft tissue interface by modifying the HTZ surface, using the load-bearing capacity of the aluminosilicate porous structure and the broad-spectrum antibacterial effect of silver nanoparticles to prevent peri-implant bacterial infection and inflammation and to improve the success rate and prolong the use of the implant.

A retrospective study comparing D1 limited lymph node dissection and D2 extended lymph node dissection for N3 gastric cancer.

Background: In countries in East Asia, the typical treatment for curable gastric cancer is gastrectomy with D2 lymphadenectomy. However, whether D2 lymphadenectomy is beneficial for high-risk N3 node disease remains controversial. We conducted a multi-institution retrospective study on patients with high-risk, locally advanced gastric cancer.

Long non-coding RNA PlncRNA-1 promotes cell proliferation and hepatic metastasis in colorectal cancer.

Emerging evidence has identified that long non-coding RNAs (lncRNAs) may play an important role in the pathogenesis of many cancer types, including colorectal cancer (CRC). However, the role of PlncRNA-1 in CRC remains unclear. The aim of our present study was to investigate the potential functions of PlncRNA-1 in CRC and to identify the underlying mechanisms of action.

[Review on the genomic imprinting at the mammalian DLK1-DIO3 cluster.].

The mammalian imprinting domain DLK1-DIO3 is located on distal human chromosome 14, mouse chromosome 12 and sheep chromosome 18. This cluster contains three imprinted protein-coding genes (Dlk1, Rtl1, and Dio3), which were expressed from the paternally inherited chromosome and several imprinted noncoding RNA genes expressed from the maternally inherited allele, such as miRNAs, snoRNAs, and large noncoding RNA Gtl2. The altered gene dosage of DLK1-DIO3 cluster resulted in several severe abnormal phenotypes in human and mouse, even death, suggesting the importance of these genes for normal development.

[Expression of phosphatase of regeneration liver-3 in human colorectal carcinoma and its prognosis value].

Objective: To investigate the expression of phosphatase of regeneration liver-3(PRL-3) protein and its relationship with tumor invasion and metastasis in human colorectal carcinoma,and elucidate prognostic value.

Methods: Immunohistochemistry method was applied to detect the PRL-3 expression in the primary tumor specimens and paired paratumor normal tissues from 46 colorectal carcinoma patients, the adenoma tissues from 6 patients with colorectal adenoma, all the metastatic lymph nodes from 29 cases and the metastatic liver lesions from 6 cases. The relationship between PRL-3 expression and clinicopathologic parameters was analyzed and a survival curve was achieved according to Kaplan-Meier method.

[Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma].

Objective: To investigate the expression of phosphatase of regenerating liver-3 (PRL- 3) mRNA and evaluate its relationship with tumor invasion and metastasis in human colorectal carcinoma.

Methods: The expression level of PRL-3 mRNA was examined semi-quantitatively in surgically resected tumor specimens, paired paratumor normal tissues from 46 CRC patients, metastatic lymph nodes and liver metastases from 18 cases with metastasis,adenoma tissues from 6 patients with colorectal adenoma (CRA). In addition,the mutation of PRL-3 gene was examined by PCR-SSCP.

[Evaluation of clinical necessity of gastrointestinal decompression after excision and anastomosis of lower digestive tract].

Objective: To evaluate the clinical necessity of postoperative gastrointestinal decompression after operation on lower digestive tract.

Methods: Three hundred and sixty-eight patients who required excision and anastomosis of lower digestive tract were randomly divided into two groups, with or without receiving gastrointestinal decompression after operation. Clinical therapeutic efficacy and complications were compared between two groups.

[Study with large slice technique and tissue microarray on lymph node involvement and micro-metastasis of rectal cancer].

Objective: To study lymph node involvement and micro-metastasis of rectal cancer with large slice technique and tissue microarray.

Methods: Large slice technique, combined with tissue microarray,was used in pathologic study of 31 patients after total mesorectal excision (TME) for rectal cancer.

Results: Nine hundred and ninety- two lymph nodes were harvested and 148 were positive.

Mesorectal spread and micrometastasis of rectal cancer studied with large slice technique and tissue microarray.

Background And Objectives: Mesorectal tissue seems to be an ideal substrate for the spreading of tumors. The aim was to study the distribution of mesorectal neoplastic foci, examine occurrence of circumferential margin involvement and investigate micrometastasis of the lymph nodes.

Methods: A large slice technique, combined with tissue microarray, was used in the pathologic study of 31 specimens operated on following the principles of total mesorectal excision (TME).

Nodal spread and micrometastasis within mesorectum.

Aim: To study the distribution of positive lymph nodes within mesorectum and to investigate the possible micrometastasis in negative lymph nodes.

Methods: Large slice technique combined with tissue microarray was used in the pathologic study of 31 specimens.

Results: A total of 992 lymph nodes were harvested and cancer metastasis was found in 148 lymph nodes.

Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats.

Aim: Pituitary adenylate cyclase activating-peptide (PACAP) is a late member of the secretin/glucagon/vasoactive intestinal peptide (VIP) family of brain-gut peptides. It is unknown whether PACAP takes part in the development of acute pancreatitis and whether PACAP or its antagonists can be used to suppress the progression of acute pancreatitis. We investigated the actions of PACAP and its receptor antagonists in acute pancreatitis on rats.

Pathological study of distal mesorectal cancer spread to determine a proper distal resection margin.

Aim: Local recurrence after curative surgical resection for rectal cancer remains a major problem. Several studies have shown that incomplete removal of cancer deposits in the distal mesorectum contributes a great share to this dismal result. Clinicopathologic examination of distal mesorectum in lower rectal cancer was performed in the present study to assess the incidence and extent of distal mesorectal spread and to determine an optimal distal resection margin in sphincter-saving procedure.

[Mesorectal spread and circumferential margin involvement of rectal cancer studied on large slice].

Objective: To provide the mode of cancer distribution in the mesorectum and circumferential resection margin.

Methods: Large slice technique was used in the pathologic study of 62 specimens operated on following the principles of total mesorectal excision (TME).

Results: More than 40% of all the observed neoplastic foci were located in the outer layer of the mesorectum in Stage III patients.

Microscopic spread of low rectal cancer in regions of mesorectum: pathologic assessment with whole-mount sections.

Aim: To assess the microscopic spread of low rectal cancer in mesorectum regions to provide pathological evidence for the necessity of total mesorectal excision (TME).

Methods: A total of 62 patients with low rectal cancer underwent low anterior resection and TME, surgical specimens were sliced transversely on the serial embedded blocks at 2.5 mm interval, and stained with hematoxylin and eosin (HE).

Gastrointestinal decompression after excision and anastomosis of lower digestive tract.

Aim: To discuss the clinical significance of postoperative gastrointestinal decompression in operation on lower digestive tract.

Methods: Three hundred and sixty-eight patients with excision and anastomosis of lower digestive tract were divided into two groups, i.e.