Network Pharmacology-Based Systematic Analysis of Molecular Mechanisms of Maxim for HSV-2 Infection.

Background: Being a traditional Chinese medicine, Maxim (GWM) is used for the treatment of various infectious diseases, and its main active ingredients are the polyphenolic substances such as polyphenols quercetin, corilagin, and geraniin. Previous studies have demonstrated the anti-HSV-1 viral activity of these three main ingredients. Through employing a network pharmacological method, the authors of the present research intend to probe the mechanism of GWM for the therapeutic treatment of HSV-2 infection.

The Effect of HBV Genotype C on the Development of HCC Differs Between Wild-Type Viruses and Those With BCP Double Mutations (T(1762)A(1764)).

Background: Association of hepatitis B virus (HBV) genotype C with hepatocellular carcinoma (HCC) development remains controversial. HBV basal core promoter (BCP) double mutations (T(1762)A(1764)) are very strong confounding factors of genotypes B and C in HCC development.

Objectives: To investigate the association of HBV genotype C with HCC development after controlling for BCP double mutations.

[Validation of a Chinese version of the child perception questionnaire].

Objective: To translate the original English version of the child perception questionnaire (CPQ(11-14)) into Chinese version and to test the psychometric properties of the Chinese version in order to use among the Chinese children.

Methods: The original English version of CPQ(11-14) was translated into Chinese, and pre-tested and cross-cultural adapted. Subsequently, the Chinese version with a general questionnaire was administered to 218 children aged from 11 to 14, clinical data on caries status and malocclusion were collected through oral health examination.