Publications by authors named "Gao-Fu Zhang"
Article Synopsis
- This study investigates the importance of achieving low disease activity state (LDAS) in treating pediatric systemic lupus erythematosus (pSLE) and examines factors that prevent reaching LDAS.
- Researchers analyzed data from 272 children with SLE, discovering that 230 achieved LDAS while 42 did not, with certain baseline conditions like endothelial cell proliferation identified as key risk factors.
- The findings suggest that non-compliance and specific clinical indicators are crucial in managing pSLE, and achieving LDAS can help minimize organ damage over time.
Background: Few studies have addressed the effects of human leukocyte antigen (HLA) alleles on different clinical sub-phenotypes in childhood steroid-sensitive nephrotic syndrome (SSNS), including SSNS without recurrence (SSNSWR) and steroid-dependent nephrotic syndrome/frequently relapse nephrotic syndrome (SDNS/FRNS). In this study, we investigated the relationship between HLA system and children with SSNSWR and SDNS/FRNS and clarified the value of HLA allele detection for precise typing of childhood SSNS.
Methods: A total of 241 Chinese Han individuals with SSNS were genotyped using GenCap-WES Capture Kit, and four-digit resolution HLA alleles were imputed from available Genome Wide Association data.
Background And Objective: Henoch-Schönlein purpura (HSP) is an important cause of chronic kidney disease in children. This meta-analysis identified risk factors associated with renal involvement in childhood HSP.
Methods: PubMed, Embase, and Web of Science were searched.
Background: The reference value for the urine albumin/creatinine ratio (ACR) varies between races and has not been previously validated in children. We assessed the ACR reference values and the factors that affect them in a population of healthy Chinese children.
Methods: A total of 1986 healthy children (1078 males, 908 females) aged 6-19 y were enrolled.
Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies.
Hum Mol Genet
May 2012
Genome-wide association studies have identified susceptibility loci for esophageal squamous cell carcinoma (ESCC). We conducted a meta-analysis of all single-nucleotide polymorphisms (SNPs) that showed nominally significant P-values in two previously published genome-wide scans that included a total of 2961 ESCC cases and 3400 controls. The meta-analysis revealed five SNPs at 2q33 with P< 5 × 10(-8), and the strongest signal was rs13016963, with a combined odds ratio (95% confidence interval) of 1.
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