High-moisture extrusion of rice bran-peanut proteins: Changes in structural properties and antioxidant activity simulating gastrointestinal digestion.

In this experiment, we investigated the structural properties, digestibility, and variations in antioxidant activity of rice bran-tissue peanut protein (RB-TPP), which was created through high-moisture extrusion between peanut protein powder (PPP) and various additions (0 %, 5 %, 10 %, 15 %, and 20 %) of rice bran (RB). The disulfide bonding and hydrophobic interactions were strengthened, and the hydrogen bonding in the RB-TPP was weakened by adding 5-10 % RB. Additionally, the β-sheet content reached its maximum at RB-10 %, which allowed the hydrophobic groups to be encapsulated ina stable protein network fiber structure, enhancing degree of organization, the thermal stability and digestibility of RB-TPP.

The mediation mechanism of calcium ions on black bean type 3 resistant starch: Metabolomics, structure characteristics and digestibility.

The type 3 resistant starch (RS3) is beneficial for blood glucose management. A high quality RS3 was provided and its formation mechanism after calcium ion (Ca) treatment was investigated in this study. The metabolomics, structure and digestion properties were evaluated.

Establishment of a N1-methyladenosine-related risk signature for breast carcinoma by bioinformatics analysis and experimental validation.

Objectives: Breast carcinoma (BRCA) has resulted in a huge health burden globally. N1-methyladenosine (mA) RNA methylation has been proven to play key roles in tumorigenesis. Nevertheless, the function of mA RNA methylation-related genes in BRCA is indistinct.

Investigation of the Effect of Rice Bran Content on the Antioxidant Capacity and Related Molecular Conformations of Plant-Based Simulated Meat Based on Raman Spectroscopy.

At present, plant-based simulated meat is attracting more and more attention as a meat substitute. This study discusses the possibility of partial substitution of rice bran (RB) for soybean protein isolate (SPI) in preparing plant-based simulated meat. RB was added to SPI at 0%, 5%, 10%, 15%, and 20% to prepare RB-SPI plant-based simulated meat by the high moisture extrusion technique.

Discovery of novel Thieno[2,3-d]imidazole derivatives as agonists of human STING for antitumor immunotherapy using systemic administration.

The activation of stimulator of interferon genes (STING) signaling pathways plays an important role in the innate immune response. Although several STING agonists have been developed recently, the majority of clinical CDN STING agonists are administered by intratumoral (IT) injection. Therefore, there remains a need to develop diverse non-CDN small-molecule STING agonists with systemic administration.

SHMT2 Drives the Progression of Colorectal Cancer by Regulating UHRF1 Expression.

Introduction: Serine hydroxymethyltransferase 2 (SHMT2) has a critical role in serine-glycine metabolism to drive cancer cell proliferation. Yet, the function of SHMT2 in tumorigenesis, especially in human colorectal cancer (CRC) progression, remains largely unclear.

Materials And Methods: CRC and paired normal samples were collected in the Department of Colorectal Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, and assessed by real-time polymerase chain reaction (qPCR) analysis, western blot (WB), and immunohistochemistry (IHC).

Effects of rice bran content on plant-based simulated meat: From the aspects of apparent properties and structural characteristics.

Rice Bran (RB) was added to soybean protein isolate (SPI) at 0%, 5%, 10%, 15% and 20% as addition to produce simulated meat by high moisture extrusion, and the apparent properties and structural characteristics of RB-SPI simulated meat were studied. The addition of 10% RB weakened the interaction among hydrogen bond (HB), hydrophobic bond (HI) and disulfide bond (DB), further increasing the hardness of simulated meat. Meanwhile, it decreased the content of intermolecular hydrogen bonding and enhanced the interaction between HI and HB, resulted in an increased tension.

Video Text Tracking With a Spatio-Temporal Complementary Model.

Text tracking is to track multiple texts in a video, and construct a trajectory for each text. Existing methods tackle this task by utilizing the tracking-by-detection framework, i.e.

Strong association between the dietary inflammatory index(DII) and breast cancer: a systematic review and meta-analysis.

The association between the Dietary Inflammatory Index (DII) and breast cancer risk has been widely reported in recent years, but there is still controversy about whether a pro-inflammatory diet is a risk factor for breast cancer. We conducted a meta-analysis to investigate the relationship between the DII and breast cancer risk in pre-menopausal and post-menopausal women. We comprehensively searched PubMed, Embase and the Cochrane Library in January 2021 to identify articles reporting an association between the DII and breast cancer risk.

Synthesis and characterization of a novel rice bran protein-cerium complex for the removal of organophosphorus pesticide residues from wastewater.

The removal of organophosphorus pesticides residues from wastewater of fruits and vegetables processing as well as other agricultural processes by a low-cost, environment-friendly, and efficient strategy is necessary. In this study, rice bran protein (RBP) was cross-linked with ceric ammonium nitrate (CAN). The results showed that the cross-linking process generated new functional groups and significantly enhanced the chemical reactivity and adsorption capacity of RBP.

Effect of protein aggregates on properties and structure of rice bran protein-based film at different pH.

Rice bran protein (RBP) aggregates were prepared by heating of RBP solution at 90 °C for 4 h at pH 2, 7, or 11 and used for preparing of packaging films. The structure and properties of RBP aggregates and RBP-based films were characterized with sodium dodecyl sulfate-polyacrylamide gel electrophoresis, transmission electron microscopy, scanning electron microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy and circular dichroism. The results showed formation of fibrillar, globular, and large molecular protein aggregates during the heating at pH 2, 7 and 11.

The effect of limited proteolysis by different proteases on the formation of whey protein fibrils.

Four proteases: trypsin, protease A, pepsin, and protease M were selected to modify whey protein concentrate (WPC) at a low degree of hydrolysis (0.1, 0.2, and 0.

Zinc or indium-mediated Barbier-type allylation of aldehydes with 3-bromomethyl-5H-furan-2-one in aqueous media: an efficient synthesis method for α-methylene-γ-butyrolactone.

A zinc or indium-mediated Barbier-type allylation of aldehydes with 3-bromomethyl-5H-furan-2-one in aqueous solvents was developed to provide an efficient route to α-methylene-γ-butyrolactone, which is synthetically very useful. The desired products were obtained in moderate to high yields in aqueous solvents. Excellent drs were achieved, among which the best diastereomeric ratios of products were found when water was used in the indium-mediated reaction, and THF-NH(4)Cl (sat, aq) (2 : 1) mixture in the zinc-mediated reaction.

Deep-sequencing analysis of the mouse transcriptome response to infection with Brucella melitensis strains of differing virulence.

Brucella melitensis is an important zoonotic pathogen that causes brucellosis, a disease that affects sheep, cattle and occasionally humans. B. melitensis strain M5-90, a live attenuated vaccine cultured from B.

Concise total synthesis of (-)-8-epigrosheimin.

A highly efficient route was developed to synthesize (-)-8-epigrosheimin in four steps from aldehyde 2 based on a substrate-controlled method. The key steps of the synthesis included (1) a stereo- and regioselective allylation addition, (2) an intramolecular translactonization, and (3) an aldehyde-ene cyclization.

Complete genome sequences of Brucella melitensis strains M28 and M5-90, with different virulence backgrounds.

Brucella melitensis is a Gram-negative coccobacillus bacteria belonging to the Alphaproteobacteria subclass. It is an important zoonotic pathogen that causes brucellosis, a disease affecting sheep, cattle, and sometimes humans. The B.