β-galactosidase instructed in situ self-assembly fluorogenic probe for prolonged and accurate imaging of ovarian tumor.

Fluorescent probes are essential for optical imaging and have been extensively employed for precise cancer diagnosis studies. β-galactosidase (β-gal) serves as a primary biomarker for ovarian cancer and has been utilized to develop imaging probes for accurate tumor diagnosis. However, traditional small molecular probes have limitations in terms of rapid diffusion and metabolic clearance from the target lesion, resulting in a short imaging window and compromised tumor-to-background ratios (TBR).

A new theoretical model for high-order harmonics of SH mode ultrasonic guided waves based on magnetostrictive mechanism.

In recent years, it was found that magnetostrictive ultrasonic guided wave transducers experimentally excited nonlinear harmonic components under a certain combination of dynamic and static magnetic fields. However, a satisfactory model for the relevant excitation mechanisms is not available. In this study, a new magnetostrictive guided wave excitation model was established and the causes for harmonics generation were analyzed.

Difficulty-Guided Variant Degradation Learning for Blind Image Super-Resolution.

Recent blind super-resolution (BSR) methods are explored to handle unknown degradations and achieve impressive performance. However, the prevailing assumption in most BSR methods is the spatial invariance of degradation kernels across the entire image, which leads to significant performance declines when faced with spatially variant degradations caused by object motion or defocusing. Additionally, these methods do not account for the human visual system's tendency to focus differently on areas of varying perceptual difficulty, as they uniformly process each pixel during reconstruction.

Covalent Organic Framework-Involved Sensors for Efficient Enrichment and Monitoring of Food Hazards: A Systematic Review.

The food safety issues caused by environmental pollution have posed great risks to human health that cannot be ignored. Hence, the precise monitoring of hazard factors in food has emerged as a critical concern for the food safety sector. As a novel porous material, covalent organic frameworks (COFs) have garnered significant attention due to their large specific surface area, excellent thermal and chemical stability, modifiability, and abundant recognition sites.

CUMS induces depressive-like behaviors and cognition impairment by activating the ERS-NLRP3 signaling pathway in mice.

Background And Objective: Endoplasmic reticulum stress (ERS), as a primary defense mechanism against stress, is closely related to mental disorders, but its pathogenesis is still unclear. This research seeks to explore the influence of ERS-nucleotide-bound oligomerized domain-like receptor protein 3 (NLRP3) signaling on mice's depressive-like behaviors and cognitive impairment.

Design And Method: We carried out a study on 32 male C57BL/6J mice to investigate how chronic unpredictable mild stress (CUMS) can give rise to depressive-like behaviors and cognitive dysfunction, randomly dividing them into control, model, inhibitor, and agonist groups.

The role of microorganisms in phosphorus cycling at river-lake confluences: Insights from a study on microbial community dynamics.

River-lake confluences are key zones in the river-lake network, essential for managing contaminant transport and transformation. However, the role of biogeochemical transformations, particularly in phosphorus (P) dynamics, has been underexplored. As a result, this study looks into the dynamics of microbial communities and how important microbes are to the cycling of P.

Nickel/Photoredox-Catalyzed Asymmetric Three-Component Cross-Coupling To Access Enantioenriched 1,1-Diaryl(heteroaryl)alkanes.

An enantioselective 1,2-dicarbofunctionalization of vinyl (hetero)arenes with alkyl bromides and aryl bromides through nickel/photoredox catalysis is described. This three-component enantioselective domino alkyl arylation of vinyl (hetero)arenes could generate a diverse array of enantioenriched 1,1-diaryl(heteroaryl)alkanes with good to excellent yields (up to 88%) and high enantioselectivities (up to 99% ). This transformation could proceed well under mild conditions with excellent chemo- and regioselectivity due to the avoidance of the use of air- and moisture-sensitive organometallic reagents and stoichiometric metal reductants.

Self-compassion and work engagement among Chinese nurses: exploring mediating effects of depression, anxiety, and stress.

Objective: Work engagement significantly influences both the quality of nursing care and nurses' job performance. In this study, we aimed to explore the mediating effects of negative emotions on the relationship between self-compassion and work engagement among Chinese nurses.

Method: A cross-sectional study was performed on nurses in a tertiary A hospital located in Henan province from September, 2023 to December, 2023.

Activatable Near-Infrared Fluorescence Probe for Hypochlorous Acid Detection in Early Diagnosis of Keloids.

Keloids represent pathologic conditions characterized by the presence of hyalinized collagen bundles and chronic inflammatory reactions. Recently, increased ROS production and disrupted apoptosis mechanisms in keloids have been reported, although the detailed mechanisms remain unclear. Herein, we developed a specific fluorescence probe, , to investigate ClO levels in keloids.

ABRACL upregulated by transcription factor CBX4 promotes proliferation and migration and inhibits the apoptosis of gastric cancer cells.

Background: Gastric cancer (GC) is a predominant health concern in many countries. Actin-binding Rho activating C-terminal-like (ABRACL) belongs to a new family of low molecular weight proteins and has been implicated in cancers. This study was implemented to elucidate the role and mechanism of ABRACL in GC.

A bidirectional pedestrian macroscopic speed model construction based on pedestrian microscopic simulation experiments.

Studies of macroscopic speed modeling of bidirectional pedestrian cross-flows have relied heavily on scenario experiments, but the data itself may be deficient because large-scale scenario experiments are not easy to organize and subjects may not be walking under normal conditions. In order to explore the possibility of using microscopic pedestrian flow simulations for macroscopic speed modeling of pedestrian flows, a series of two-way pedestrian cross-flow simulation experiments were designed. Bidirectional pedestrian flows are defined as Peds1 and Peds2.

Broad-Spectrum Engineered Multivalent Nanobodies Against SARS-CoV-1/2.

SARS-CoV-2 Omicron sublineages escape most preclinical/clinical neutralizing antibodies in development, suggesting that previously employed antibody screening strategies are not well suited to counteract the rapid mutation of SARS-CoV-2. Therefore, there is an urgent need to screen better broad-spectrum neutralizing antibody. In this study, a comprehensive approach to design broad-spectrum inhibitors against both SARS-CoV-1 and SARS-CoV-2 by leveraging the structural diversity of nanobodies is proposed.