Big data analysis and machine learning of the role of cuproptosis-related long non-coding RNAs (CuLncs) in the prognosis and immune landscape of ovarian cancer.

Background: Ovarian cancer (OC) is a severe malignant tumor with a significant threat to women's health, characterized by a high mortality rate and poor prognosis despite conventional treatments such as cytoreductive surgery and platinum-based chemotherapy. Cuproptosis, a novel form of cell death triggered by copper ion accumulation, has shown potential in cancer therapy, particularly through the involvement of CuLncs. This study aims to identify risk signatures associated with CuLncs in OC, construct a prognostic model, and explore potential therapeutic drugs and the impact of CuLncs on OC cell behavior.

Heat-shock protein 70 reduces apoptosis in the gills and hepatopancreas of Marsupenaeus japonicus under low-temperature stress.

The heat shock response (HSR) has important functions in a cell's reaction to stresses. The HSR is regulated and effected by heat shock proteins (HSPs) and heat shock factors (HSFs). Herein, the full-length cDNA of Marsupenaeus japonicus heat shock protein 70 (MjHSP70) was isolated and sequenced.

Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways.

Periodontal ligament stem cells (PDLSCs) bring new hope to patients with poor periodontium recovery and impaired regeneration. However, the complex inflammatory microenvironment continually inhibits stem cell function and hinders stem cell therapy effectiveness. Melatonin is a naturally occurring neurohormone that participates in the regulation of a large spectrum of biological functions.

Self-assembled patient-derived tumor-like cell clusters for personalized drug testing in diverse sarcomas.

Several patient-derived tumor models have emerged recently. However, soft tissue sarcomas (STSs) present a challenge in developing preclinical drug-testing models due to their non-epithelial and complex nature. Here, we report a model termed patient-derived tumor-like cell clusters (PTCs) derived from STS patients.

Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research.

Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in the field of biosciences for their role in intercellular communication in various physiological and pathological processes. Their ubiquitous presence in bodily fluids and cell-specific characteristics make them promising candidates as biomarkers. Additionally, their ability to transport biological therapeutics across different biological barriers to specific target cells underscores their significant translational potential for diagnostic and therapeutic purposes.

increases serum vitamin D metabolite levels and modulates intestinal flora to alleviate osteoporosis in mice.

The elderly population is prone to osteoporosis, owing to the deterioration of the skin, liver, and kidney functions. Vitamin D (VD) supplementation has a limited effect, and VD deficiency is mostly treated with medication. Several studies have shown that the gut microbiota alters intestinal VD metabolism and that probiotic supplements can influence circulating VD levels.

Crystal symmetry modification enables high-ranged in-plane thermoelectric performance in n-type SnSe crystals.

SnSe crystal has witnessed significant advancements as a promising thermoelectric material over the past decade. Its in-plane direction shows robust mechanical strength for practical thermoelectric applications. Herein, we optimize the in-plane thermoelectric performance of n-type SnSe by crystal symmetry modification.

The effects of test on associative memory depend on semantic relevancy levels: evidence of event-related potentials.

This study aims to investigate how the level of semantic relevance influences the effects of test on associative memory through bottom-up cognitive processes. This study manipulated the levels of semantic relevancy using synonym and nonsynonym pairs in a three-phase testing effect paradigm (an initial encoding phase, a cued-recall test as retrieval practice, and a final test phase) to explore the effects of testing effect and semantic relevancy on associative recognition by bottom-up processes using the event-related potential (ERP). The behavioral results suggested that the test practice (relative to the restudy) significantly facilitated memory retrieval in high semantic relevancy pairs during the final test phase.

Magnetic circularly polarized luminescence in Fe-sensitized YbPO: Phase transition, energy transfer and magneto-optical effect.

This study explores the photoluminescence (PL) and chiral luminescence properties of Fe-sensitized YbPO nanocrystals embedded in magneto-optical (MO) glass matrices. A combination of advanced characterization techniques, including X-ray diffraction (XRD), photoluminescence excitation (PLE) and emission (PL) spectroscopy, circular dichroism (CD), circularly polarized luminescence (CPL), magnetic circularly polarized luminescence (MCPL), and vibrating sample magnetometry (VSM), was employed to investigate the material's structural, optical, and magnetic properties. The XRD and electron diffraction results reveal the tetragonal-to-monoclinic phase transition of YbPO upon doping, introducing asymmetric YbO coordination.

Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2.

Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. This study demonstrates that TRPC1 is modified by small ubiquitin-related modifier (SUMO)ylation. Our findings suggest a notable increase in microglial TRPC1 SUMOylation within both the middle cerebral artery occlusion reperfusion (MCAO/R) model and the in vitro oxygen-glucose deprivation/regeneration model.

Simulation of Interface Characteristics and Charge Transfer Dynamics for Layered Electrodes Using Cascade Capacitance in Supercapacitors by COMSOL Software.

In this investigation, the performance disparity between layer-by-layer (LbL) electrodes and uniformly mixed (UM) electrodes in supercapacitors is evaluated using COMSOL Multiphysics software by utilizing a two-dimensional asymmetric structure simulation model where the LbL electrodes consist of ZnMnO and graphene oxide (GO) with varying layering sequences and scales ranging from millimeters to microns. The results revealed that the LbL electrodes significantly augmented the supercapacitor's performance by enhancing charge and mass transport mechanisms. Across both millimeter and micrometer scales, the LbL electrodes surpassed the uniformly mixed electrodes due to their larger surface area and greater ionic accessibility, resulting in more effective charge storage and faster electron transfer.

Triglyceride-glucose index and triglyceride-glucose-body mass index as prognostic factors for early stage breast cancer patients receiving neoadjuvant chemotherapy.

Background: Insulin resistance (IR) is closely associated with the risk of breast cancer. The triglyceride-glucose (TyG) index and the triglyceride-glucose-body mass index (TyG-BMI) are considered surrogate indicators of IR; however, their prognostic value in breast cancer patients has not been discussed. The purpose of this study is not only to explore whether the TyG index and the TyG-BMI can predict the chemotherapy response and long-term prognosis of breast cancer patients receiving neoadjuvant chemotherapy (NACT) but also to investigate the possible mediating mechanism and to analyze the relationship between TyG-related enzyme expression and drug resistance and prognosis.

Study of the role of transmembrane emp24 domain-containing protein 2 in oral squamous cell carcinoma.

Objective: This study aimed to investigate the role of transmembrane emp24 domain-containing protein 2 (TMED2) in oral squamous cell carcinoma (OSCC).

Methodology: A bioinformatics analysis was first conducted to explore TMED2 expression in OSCC and its relation with overall survival. The analysis results were further verified by assessing TMED2 expression levels in human normal oral keratinocyte cells and human OSCC cell lines using quantitative real-time polymerase chain reaction and the Western blot.

Designing High-Damping, Optically Clear Ionogels through Competitive Binding for Flexible and Impact-Resistant Applications.

Developing damping materials that are both optically transparent and mechanically robust, while offering broad frequency damping capacity, is a significant challenge─particularly for devices that require protection without compromising visual clarity. Conventional methods often either fail to maintain transparency or involve complex designs that are difficult to implement. Here, we present an ionogel system that integrates a physically cross-linked elastic copolymer network with a viscous ionic liquid.

Diversity and Multigene Phylogeny of the Genus (Agaricales, Basidiomycota).

is known as a northern-hemisphere-distributed genus with important economic values, especially in Western China. However, its species diversity in Asia and the phylogeny of this genus have not been critically studied. Based on worldwide sampling and multi-locus DNA sequence data (ITS, LSU, , ), the phylogeny of was reconstructed, and the species diversity in Asia was critically studied on the basis of morphology and phylogeny.

Alkylated DNA repair by a novel HhH-GPD family protein from Crenarchaea.

HhH-GPD (helix-hairpin-helix-glycine/proline/aspartate) family proteins are involved in DNA damage repair. Currently, mechanism of alkylated DNA repair in Crenarchaea has not been fully clarified. The hyperthermophilic model crenarchaeon Saccharolobus islandicus REY15A possesses a novel HhH-GPD family protein (Sis-HhH-GPD), where its Ser152 corresponds to a conserved catalytic Asp in other HhH-GPD homologs.

Photodynamic therapy combined with quaternized chitosan antibacterial strategy for instant and prolonged bacterial infection treatment.

Drug-resistant bacterial infections represent a critical global public health challenge, driven largely by the misuse and overuse of antibiotics. Tackling the growing threat of bacterial resistance necessitates the development of innovative antibacterial agents that function independently of traditional antibiotics. In this study, novel antibacterial nano-micelles were rationally designed by conjugating quaternized chitosan with the photosensitizer chlorin e6.

Structure and function of the uracil DNA glycosylases from hyperthermophiles: Elucidating DNA uracil repair mechanisms: A review.

Base deamination can lead to DNA base damage, among which cytosine deamination to uracil occurs frequently. Before repair, replication of uracil in DNA will generate GC → AT transversion mutation. Since base deamination is accelerated by high temperature, genomic DNA stability of hyperthermophiles, which grow optimally above 75 °C, is facing a severe threat by the elevated base deamination created by their living high temperature environments.

Intratumoral oncolytic virus OH2 injection in patients with locally advanced or metastatic sarcoma: a phase 1/2 trial.

Background: Intratumoral oncolytic herpes simplex virus 2-GM CSF (OH2) injection has shown safety and antitumor efficacy in patients with solid tumors. Here, we examined the safety and efficacy of OH2 as a single agent or in combination with HX008, an NMPA-approved PD-1 inhibitor, in locally advanced or metastatic sarcoma patients.

Methods: This multicenter, phase 1/2 trial enrolled patients with injectable sarcoma lesions, who had failed at least 1 or more lines of standard treatment.

Skeletal Muscle Stem Cells and the Microenvironment Regulation in Sarcopenia:A Review.

Sarcopenia is an age-related degenerative skeletal muscle disorder characterized by the loss of skeletal muscle mass and function during aging.Sarcopenia can impair the elderly's ability to perform daily activities and is associated with high risks of falls,fractures,and hospitalization.It seriously affects the quality of life of the elderly and becomes one of the major health problems in the aging society.

Synthesis of 2,7-Dihydrooxepine-spirodithiophene Derivatives via an Intramolecular Ring Closure Reaction.

Spiro architectures with π-conjugation have improved thermal stability and stronger photosensitivity, making them potentially useful for organic optoelectronic devices. Our recent work has demonstrated the synthetic chemistry of a novel thiophene oligomer combining 2,7-dihydrooxepine and dispiro structure and derived it into A-D-A-type compounds. The optical spectroscopy and electrochemical characteristics were investigated.

The symbiont Wolbachia increases resistance to bifenthrin in Ectropis grisescens by regulating the host detoxification function.

The global issue of insecticide resistance among pests is a major concern. Ectropis grisescens Warren (Lepidoptera: Geometridae), is a highly destructive leaf-eating pest distributed in tea plantations throughout China and Japan, and has exhibited resistance to various insecticides. Recent studies suggest that insect symbionts play a role in influencing insecticide resistance, however, their specific involvement in E.

A thermosensitive chitin hydrogel with mild photothermal-chemotherapy for facilitating multidrug-resistant bacteria infected wound healing.

Bacterial infection of skin wounds leads to serious health problems, including skin defects, inflammatory pain, and even death. To meet the requirements for successful treatment of complicated wounds, a multifunctional dressing is thus highly desirable. In this work, a thermosensitive hydrogel dressing (HBCA) exhibiting injectability, adaptiveness and mild photothermal antibacterial activity was developed for effective infected wound treatment.

Assessing the ecological effects of the World's Largest Forestry Eco-engineering: Three-North Protective Forest Program within the initially scheduled range from 1978 to 2022.

China's Three-North Protective Forest Program (TNP) is the world's most ambitious afforestation project (ongoing from 1978 to 2050), which aims to increase forest coverage through afforestation and reforestation, protect agriculture, reduce soil erosion, and control desertification. Although TNP has been ongoing for 45 years, its rationales and effects remain uncertain. Here, we conducted a range-wide assessment of TNP by analyzing data from >10,000 scenes of satellite images and >50,000 field survey plots.

Ovarian cancer-derived TGF-β1 induces cancer-associated adipocytes formation by activating SMAD3/TRIB3 pathway to establish pre-metastatic niche.

Ovarian cancer (OC) is prone to adipose tissue metastasis. However, the underlying molecular mechanisms remain elusive. Here, we observed that omental adipocytes were induced into cancer-associated adipocytes (CAAs) by OC-derived TGF-β1 to establish a pre-metastatic niche (PMN) through collagen and fibronectin secretion.