AVE0991 ameliorates dopaminergic neuronal damage in Parkinson's disease through HOTAIRM1/miR-223-3p/α-synuclein axis.

Parkinson's disease (PD) is a prevalent type of neurodegenerative disorder. AVE0991, a non-peptide analogue of Ang-(1-7), by which the progression of PD has been discovered to be ameliorated, but the specific mechanism whereby AVE0991 modulates the progression of PD re-mains unclear. The mice overexpressing human α-syn (A53T) were established to simulate PD pathology, and we also constructed an in vitro model of mouse dopaminergic neurons overexpressing hα-syn (A53T).

Supramolecular assembly strategy of modified starch chains for achieving recyclable emulsion biocatalysis within a narrow pH range.

Stimuli-responsive Pickering emulsions are promising in biocatalysis for their ease of product separation and emulsifier recovery. However, pH responsiveness, though simple and cost-effective, faces challenges in precise control and narrow transition ranges, limiting its use in enzymatic catalysis. Herein we introduced amorphous octenyl succinic anhydride-modified debranched starch chains (Am-OSA-St) to control emulsion properties within a pH range suitable for enzymatic catalysis.

Effects of moisture regulation and heat treatment synergy on structural properties and digestibility of jackfruit seed starch.

To investigate the impact of moisture regulation and heat treatment synergy on the structural properties and digestibility of jackfruit seed starch (JSS), starch samples underwent heat-moisture treatment (HMT) and annealing treatment (ANN) with varying moisture content (10-30 % for HMT at 120 °C, and 50-90 % for ANN at 40 °C). The physicochemical properties and in vitro digestibility of modified-JSS were systematically investigated. Results showed that the birefringence intensity of HMT-JSS decreased at high moisture levels but remained unchanged for HMT-JSS and ANN-JSS at low moisture levels.

Revealing the mechanism of bifunctional PtLa electrocatalyst for highly efficient methanol oxidation, hydrogen evolution, and coupling reaction.

The development of clean energy solutions, such as fuel cells and hydrogen energy, is crucial for addressing the global energy shortage. Platinum (Pt)-based catalysts are widely used in fuel cells and hydrogen energy generation (for example, via water electrolysis). However, reducing the amount of Pt used while maintaining the catalytic performance of such catalysts is essential.

Endothelin-1 potentiated constriction in preeclampsia placental veins: Role of ETAR/ETBR/CaV1.2/CALD1.

Background: Placenta plays a vital role in preeclampsia. The present study investigated the role of endothelin-1 (ET-1) and its receptors in preeclampsia placenta.

Method: Placenta samples were collected from normal and preeclampsia pregnancies, with one single fetus.

Single-cell and spatial transcriptome characterize coinhibitory cell-cell communications during histological progression of lung adenocarcinoma.

Introduction: Lung adenocarcinoma, a prevalent and lethal malignancy globally, is characterized by significant tumor heterogeneity and a complex tumor immune microenvironment during its histologic pattern progression. Understanding the intricate interplay between tumor and immune cells is of paramount importance as it could potentially pave the way for the development of effective therapeutic strategies for lung adenocarcinoma.

Methods: In this study, we run comparative analysis of the single-cell transcriptomic data derived from tumor tissues exhibiting four distinct histologic patterns, lepidic, papillary, acinar and solid, in lung adenocarcinoma.

Electronic Modulation and Symmetry-Breaking Engineering of Single-Atom Catalysts Driving Long-Cycling Li-S Battery.

Developing efficient and durable single-atom catalysts is vitally important for the sulfur redox reaction (SROR) in Li-S battery, while it remains enormous challenging. Herein, undercoordinated Ni-N moieties anchored on N,S-codoped porous carbon (Ni-NSC) is obtained to enhance the SROR. The experiments and theoretical calculations indicate that the symmetry-breaking charge transfer in Ni single-atom catalyst originates from tuning effect of sulfur atoms mediated Ni-N moieties, which can both facilitate the chemical adsorption by formation of N-Ni⋅⋅⋅S , and achieve a rapid redox conversion of polysulfides because of the enhanced electron transfer.

2D Membranes Interlayered with Bimetallic Metal-Organic Frameworks for Lithium Separation from Brines.

Efficient lithium extraction from salt lakes is essential for a sustainable resource supply. This study tackles the challenge of separating Li from Mg in complex brines by innovatively integrating two-dimensional (2D) graphene oxide (GO) with bimetallic metal-organic frameworks (MOFs). Zn and Co ions are confined within GO interlayers through an in situ synthesis, forming a 2D Zn-Co MOFs/GO membrane (Zn-Co-GOM).

Nursing bibliometric analysis of wound infections.

Background: This paper aims to perform a bibliometric analysis of research pertaining to the nursing care of infected wounds. It also aims to examine the current focal points and trends in research development. The paper offers research references that may be useful for practitioners interested in related areas.

Effects of different carbapenemase and siderophore production on cefiderocol susceptibility in .

The resistance mechanism of Gram-negative bacteria to the siderophore antibiotic cefiderocol is primarily attributed to carbapenemase and siderophore uptake pathways; however, specific factors and their relationships remain to be fully elucidated. Here, we constructed cefiderocol-resistant (CRKP) strains carrying different carbapenemases and knocked out siderophore genes to investigate the roles of various carbapenemases and siderophores in the development of cefiderocol resistance. Antimicrobial susceptibility testing revealed that both and significantly increased the minimum inhibitory concentration (MIC) of (KP) to cefiderocol, while showed a modest increase.

BES-Designer: A Web Tool to Design Guide RNAs for Base Editing to Simplify Library.

CRISPR/Cas base editors offer precise conversion of single nucleotides without inducing double-strand breaks. This technology finds extensive applications in gene therapy, gene function analysis, and other domains. However, a crucial challenge lies in selecting the appropriate guide RNAs (gRNAs) for base editing.

Mechanistic Studies of Small Molecule Ligands Selective to RNA Single G Bulges.

Small-molecule RNA binders have emerged as an important pharmacological modality. A profound understanding of the ligand selectivity, binding mode, and influential factors governing ligand engagement with RNA targets is the foundation for rational ligand design. Here, we report a novel class of coumarin derivatives exhibiting selective binding affinity towards single G RNA bulges.

Marker-Assisted Selection of Jacalin-Related Lectin Genes and Derived from Sea Rice 86 Enhances Salt Tolerance in Rice.

Soil salinization limits rice growth and is an important restriction on grain yield. Jacalin-related lectins are involved in multiple stress responses, but their role in salt stress responses and use as molecular markers for salt tolerance remain poorly understood. Salt stress treatments and RT-qPCR analyses of Sea Rice 86 (SR86), 9311, and Nipponbare (Nip) showed that and enhanced tolerance of salt stress in SR86.

Antidiabetic and Antigout Properties of the Ultrasound-Assisted Extraction of Total Biflavonoids from Revealed by In Vitro and In Silico Studies.

In this study, the extraction, purification and metabolic enzyme inhibition potential of were investigated. In order to extract the total biflavonoids from (SDTBs), the optimum extraction process was obtained by optimizing the ultrasonic extraction parameters using response-surface methodology. This resulted in a total biflavonoid content of 22.

[Evolution Characteristics and Typical Pollution Episodes of PM and O Complex Pollution in Bozhou City from 2017 to 2022].

In China, atmospheric pollution exhibits a complex pattern, with simultaneous exceedances of fine particulate matter （PM） and ozone （O） levels becoming evident. To understand the complex pollution characteristics and evolution patterns of PM and O in Bozhou City, various methods such as weather classification, analysis of typical pollution processes, and investigation of precursor sources were employed to explore the pollution and variations of PM and O in Bozhou City from 2017 to 2022 and subsequently analyze their causes and precursor sources. The results indicated that： ① PM-O complex pollution in Bozhou City mostly occurred under high-pressure weather conditions, with daytime high temperatures and low humidity promoting the formation of O pollution, whereas nighttime high humidity and atmospheric oxidative conditions promoted the generation of secondary components such as nitrates and ammonium salts in PM.