Effects of psychosocial factors on postpartum depression: a half-longitudinal mediation analysis of cognitive reactivity.

Background: The prevention and treatment of perinatal depression are currently the focus of perinatal health care, with cognitive reactivity confirmed to be an important predictor. However, how cognitive reactivity mediates the relationship between psychosocial factors (e.g.

Determinative sleep traits associated with dyslipidemia in obstructive sleep apnea patients.

Background: Obstructive sleep apnea (OSA) is recognized to increase the risk of dyslipidemia; however, the specific sleep traits in OSA that influence dyslipidemia are poorly understood. This study sought to determine which sleep traits are independently associated with dyslipidemia and serum lipid profiles in patients with OSA.

Methods: In this cohort study, 5239 participants were included from the Sleep Heart Health Study.

Ureases in nature: Multifaceted roles and implications for plant and human health - A review.

Urease, a multifunctional enzyme that catalyzes the hydrolysis of urea into ammonia, plays a pivotal role in nitrogen metabolism across diverse organisms. While essential for survival, its unregulated activity is implicated in numerous pathologies, including peptic ulcers, nephropathy, and gastric cancer, as well as agricultural challenges such as soil ammonium depletion and reduced nitrogen-use efficiency. Beyond its canonical enzymatic function, urease engages in protein-protein interactions with bioactive counterparts like jaburetox, canatoxin, and soyuretox plant-derived proteins with insecticidal, antifungal, and membranolytic properties.

Medical experiences of patients with breast cancer using smart hospital apps: A qualitative study.

Objective: To examine medical experiences of patients with breast cancer with smart hospital apps and their expectations for future development.

Methods: A descriptive qualitative research method was employed to conduct in-depth interviews with 40 patients with breast cancer who used smart hospital apps. Content analysis was performed to analyze and organize the interview data.

Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells.

This study reports the isolation and characterization of six novel tetrahydroxanthone derivatives, paraconixanthones A - F (1-6), a new diphenyl ether (7), and thirteen known compounds (8-20) from the endophytic fungus Paraconiothyrium sp. AC31. The chemical structures were elucidated using NMR, MS, X-ray diffraction, and ECD analyses.

AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity.

Bile acid metabolism and antitumor immunity are both disrupted during liver cancer progression. However, the complex regulatory relationship between them remains largely unclear. Here, we find that loss of aldo-keto reductase 1D1 (AKR1D1) promotes the accumulation of isolithocholic acid (iso-LCA) through gut microbiome dysregulation, thereby impairing the cytotoxic function of natural killer (NK) cells and leading to the accelerated development of hepatocellular carcinoma (HCC).

Global, regional, and national burden of breast, cervical, uterine, and ovarian cancer and their risk factors among women from 1990 to 2021, and projections to 2050: findings from the global burden of disease study 2021.

Background: Female breast cancer, cervical cancer, uterine cancer, and ovarian cancer (FBCUO) pose a significant threat to global public health. Data from the Global Burden of Disease, Injuries, and Risk Factors Study (GBD) 2021 provide critical insights that can guide the understanding and management of these cancers. Our study aims to offer comprehensive global, regional, and national estimates of the FBCUO cancer burden and its attributable risk factors from 1990 to 2021, as well as project future incidence trends up to 2050.

Optimal fiber mix and prediction model for compressive strength of hybrid fiber reinforced concrete.

Incorporating single or mixed types of fibers into concrete is an effective method for enhancing its performance. This study aimed to investigate the optimal fiber mix for hybrid fiber reinforced concrete (HFRC) that includes end-hooked steel fibers (ESF), corrugated steel fibers (CSF), and polypropylene fibers (PF), and to predict its compressive strength. To this end, three combinations of HFRC were designed: ESF and CSF (EC-HFRC), ESF and PF (EP-HFRC), and CSF and PF (CP-HFRC), respectively.

ENO1-BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism.

Enolase 1 (ENO1) is a glycolytic enzyme involved in tumour progression that performs a variety of classical and nonclassical functions. However, the mechanism by which it promotes tumour progression is still not fully understood. Here, we found that ENO1 can bind to β-site amyloid precursor protein cleaving enzyme 2 (BACE2), a codependent gene of ENO1, in liver cancer cells.

GADD45α is a direct target of TFEB and contributes to tacrolimus-induced chronic nephrotoxicity.

Tacrolimus-induced chronic nephrotoxicity (TICN) hinders its long-term use, but its mechanism remains unclear. Tacrolimus exerts its pharmacological effect by inhibiting calcineurin and its substrate NFAT. Whether the inhibition of other calcineurin substrates is related to TICN remains to be explored.

Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.

Metabolic enzymes play significant roles in the pathogenesis of various cancers through both canonical and noncanonical functions. Hexokinase domain-containing protein 1 (HKDC1) functions beyond glucose metabolism, but its underlying mechanisms in tumorigenesis are not fully understood. Here, we demonstrate that nuclear-localized HKDC1 acts as a protein kinase to promote hepatocellular carcinoma (HCC) cell proliferation.

VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis.

Ferroptosis is a form of iron-dependent programmed cell death, which is distinct from apoptosis, necrosis, and autophagy. Mitochondria play a critical role in initiating and amplifying ferroptosis in cancer cells. Voltage-Dependent Anion Channel 1 (VDAC1) embedded in the mitochondrial outer membrane, exerts roles in regulation of ferroptosis.

Aculeapyridones A-Q, Pyranopyridone Alkaloids with Protective Effects against Acetaminophen-Induced Acute Liver Injury Discovered from a Coculture of WHUF0198 and a sp.

In the search for novel natural products with hepatoprotective effects against acetaminophen-induced acute liver injury, the marine-derived fungus WHUF0198 was investigated. Seventeen undescribed pyranopyridone alkaloids, aculeapyridones A-Q (-), were isolated by bioactivity-guided fractionation of an extract obtained by coculture of the WHUF0198 with the mangrove-associated fungus sp. DM27.

Improving the Effectiveness of Sample Size Re-Estimation: An Operating Characteristic Focused, Hybrid Frequentist-Bayesian Approach.

Sample size re-estimation (SSR) is perhaps the most used adaptive procedure in both frequentist and Bayesian adaptive designs for clinical trials. The primary focus of all current frequentist and Bayesian SSR procedures is type I error control. We propose a hybrid frequentist-Bayesian SSR approach that focuses on optimizing operating characteristics (OC), which uses simulations to investigate the associated OC and adjusts accordingly.

Biocontrol Potential of Rhizospheric Bacillus Strains Against Jagger Causing Lettuce Drop.

Phytopathogenic Jagger causes lettuce drop, a destructive soil-borne disease. As potential biocontrol agents for this disease, 2 of 31 bacterial strains isolated from soil samples from fields containing Jagger were identified using in vitro antagonistic assays against Jagger. Bioactivity experiments showed that Bac20 had higher inhibitory activity against Jagger than Bac45.

Influence of Ag-18Cu-10Zn Filler Material on Microstructure and Properties of Laser-Welded Al/Cu Dissimilar Butt Joints.

Dissimilar welding between aluminum and copper poses significant challenges, primarily due to differences in their thermal and mechanical properties, resulting in brittle intermetallic compounds, limited joint strength, and high electrical resistivity. This study aims to overcome these issues by employing Ag-18Cu-10Zn filler material and optimizing laser power with a focus on improving joint strength and electrical conductivity. The results indicate that the incorporation of silver and zinc enhances the phase composition and microstructure of the weld.

Retraction: The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice.

[This retracts the article DOI: 10.1039/C9RA07262D.].

Advancing autotrophic nitrogen removal in low C/N ratio wastewater: Innovative application of supercapacitor to enhance microbial electrolysis cells.

This study presents a novel approach, the Supercapacitor Microbial Electrolysis Cell (SC-MEC), which utilizes a supercapacitor as an external power source to enhance the efficiency of autotrophic nitrogen removal in low C/N ratio wastewater. The results demonstrated that the SC-MEC system, operating under anaerobic conditions and devoid of any organic carbon source, exhibited exceptional performance in ammonia oxidation and total nitrogen (TN) removal when solely relying on ammonia nitrogen as the electron donor. Operating at a voltage of 1.

Q&A with Ping Gao.

Ping Gao, guest editor of the cancer metabolism special issue, spoke with Cell Reports about his scientific interests and his lab's focus on investigating the metabolic reprogramming in cancer cells and immune cells in the tumor microenvironment. Ping also discussed recent developments and future directions in the field.

Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.

Mitochondria contain a 16-kb double stranded DNA genome encoding 13 proteins essential for respiration, but the mechanisms regulating transcription and their potential role in cancer remain elusive. Although methyl-CpG-binding domain (MBD) proteins are essential for nuclear transcription, their role in mitochondrial DNA (mtDNA) transcription is unknown. Here we report that the MBD2c splicing variant translocates into mitochondria to mediate mtDNA transcription and increase mitochondrial respiration in triple-negative breast cancer (TNBC) cells.

Carbonic anhydrase 2 facilitates sorafenib resistance by counteracting MCT4-mediated intracellular pH dysregulation in HCC.

Sorafenib, the targeted therapy for hepatocellular carcinoma (HCC), has been utilized in clinics for over a decade. However, its effectiveness is severely hindered by acquired drug resistance, the mechanisms of which remain largely elusive. In this study, we identify that carbonic anhydrase 2 (CA2) is a key regulator of sorafenib resistance.

Case report: Mullerian cyst of mediastinum: report of two cases.

Posterior mediastinal Mullerian cyst is rare. Due to its special location, it is easy to be misdiagnosed clinically, imaging and pathologically. Imaging is often misdiagnosed as a bronchial cyst or neurogenic tumor.