Comparative Analysis of Myofiber Characteristics, Shear Force, and Amino Acid Contents in Slow- and Fast-Growing Broilers.

Skeletal muscle fiber characteristics are pivotal in assessing meat quality. However, there is currently a lack of research precisely quantifying the total number of myofibers (TNM) of skeletal muscles. This study used Arbor Acres (AA) broilers and Wenchang (WC) chickens to determine the TNM of several skeletal muscles and the meat quality of the pectoralis major muscle (PM).

Construction of a mitochondrial-targeting near-infrared fluorescent probe for detection of viscosity changes in type 2 diabetes mellitus and nonalcoholic steatohepatitis.

The intracellular viscosity plays a pivotal role as a physicochemical factor and an important indicator of organelles performance. Abnormal changes in subcellular viscosity are often associated with cellular malfunction and various diseases. Nonalcoholic steatohepatitis (NASH) is the most common liver disease related with type 2 diabetes mellitus (T2DM), and both are linked to aberrant mitochondrial viscosity.

The effects of perceived sport environment on sport gains of Chinese university students: chain mediation between physical activity behavior and sport learning self-efficacy.

Introduction: Sports gains reflect the sports development of college students, which is a direct reflection of the quality of school sports work, while the perception of sports environment, physical activity behavior, and self-efficacy in sports learning are closely related to their sports gains, which directly affects their effectiveness and interest in sports learning.

Objective: To investigate the effects of perceived sports environment on Chinese college students' sport gains, and to verify the mediating roles of physical activity behavior and self-efficacy in sport learning.

Methods: A survey of 2,207 Chinese university students was conducted using the sport environment perception scale, sport gain scale, physical activity behavior scale, and sport learning self-efficacy scale.

Molecular Regulation of Photosynthetic Carbon Assimilation in Oat Leaves Under Drought Stress.

Common oat ( L.) is one of the important minor grain crops in China, and drought stress severely affects its yield and quality. To investigate the drought resistance characteristics of oat seedlings, this study used Baiyan 2, an oat cultivar at the three-leaf stage, as the experimental material.

A pilot study of tofacitinib citrate with 308-nm excimer laser for the treatment of vitiligo.

Background: Vitiligo is a clinically prevalent acquired skin disorder characterized by depigmentation. Currently, the therapeutic options for vitiligo are restricted, and numerous issues exist, such as a prolonged treatment course, unsatisfactory therapeutic efficacy, adverse reactions, and a high propensity for recurrence after treatment cessation.

Aim: To assess the safety and efficacy of combined treatment involving oral tofacitinib citrate (TC) and a 308-nm excimer laser (EL), with the aim of discovering a rapid and effective treatment approach to minimize the side effects of various drugs.

Epitope-imprinted biomaterials with tailor-made molecular targeting for biomedical applications.

Molecular imprinting technology (MIT), a synthetic strategy to create tailor-made molecular specificity, has recently achieved significant advancements. Epitope imprinting strategy, an improved MIT by imprinting the epitopes of biomolecules (e.g.

ZIF-8 as efficient carriers for polysaccharide from Tetrastigma Hemsleyanum Diels et Gilg in acute lung injury induced by lipopolysaccharides.

Acute lung injury (ALI) is a critical respiratory syndrome significantly impacting patient health. Tetrastigma hemsleyanum Diels et Gilg (Sanyeqing, SYQ) is a traditional Chinese medicine and its polysaccharides (SYQP) have demonstrated efficacy in counteracting lipopolysaccharide-induced ALI. This study characterized the structure of SYQP and synthesized the SYQP@ZIF-8 composite using biomimetic mineralization, evaluating encapsulation and release efficiency.

Integrated analysis of transcriptome and proteome reveals a core set of genes involved in osteoblast under oxidative stress.

Osteoblasts dysfunction, induced by oxidative stress (OS), is a significant contributor to the pathogenesis of osteoporosis. However, the genes implicated in regulating osteoblast dysfunction remain unclear. Here, we employed the hydrogen peroxide (HO)-induced osteoblast dysfunction model to assess its impact on osteoblast phenotype and to conduct transcriptome and proteome analyses in osteoblasts under OS.

Role of the PGAM5-CypD mitochondrial pathway in methylglyoxal-induced bone loss in diabetic osteoporosis.

Diabetic osteoporosis (DOP) is a skeletal complication with a high rate of disability. It results in a great burden to the patient's family and society. Methylglyoxal (MG) is a toxic by-product of the glycolytic process that occurs during diabetic conditions.

Integrative multi-omics and network pharmacology reveal the mechanisms of Fangji Huangqi Decoction in treating IgA nephropathy.

Ethnopharmacological Relevance: Fangji Huangqi Decoction (FJHQD), a classical Chinese herbal formulation, has demonstrated significant clinical efficacy in the treatment of IgA nephropathy (IgAN), although its mechanisms remain poorly understood.

Aim Of The Study: This study aims to investigate the renal protective mechanisms of FJHQD using an integrated approach that combines transcriptomics, proteomics, and network pharmacology.

Methods: Renal glomerular structure changes were assessed via hematoxylin and eosin (H&E) and Masson staining.

Identification of novel natural anti-browning agents based on phenotypic and metabolites differences in potato cultivars.

This study aimed to elucidate the changes of browning-related metabolite in fresh-cut potato and to identify anti-browning agents. Metabolomics and weighted correlation network analysis (WGCNA) were used to identify metabolites and correlate them with potato browning traits. A total of 79 browning trait-positive-related metabolites and 19 browning trait-negative-related metabolites were obtained from four key modules via WGCNA.

Safety and efficacy of a novel dexmedetomidine nasal spray for pre-anesthetic sedation in children: a randomized, double-blind, placebo-controlled trial.

Background: Off-label intranasal administration of injectable dexmedetomidine has been widely applied in the pediatric sedation setting. However, the development of an improved drug delivery system that is easy to use is needed. We developed a novel dexmedetomidine nasal spray that can be administered directly without dilution or configuration for pediatric pre-anesthetic sedation.

DNA sequences alignment method using sparse index on pan-genome graph.

The graph of sequences represents the genetic variations of pan-genome concisely and space-efficiently than multiple linear reference genome. In order to accelerate aligning reads to the graph, an index of graph-based reference genomes is used to obtain candidate locations. However, the potential combinatorial explosion of nodes on the sequence graph leads to increasing the index space and maximum memory usage of alignment process considerably, especially for large-scale datasets.

Chromolaena odorata affects soil nitrogen transformations and competition in tropical coral islands by altering soil ammonia oxidizing microbes.

Invasive plants can change the community structure of soil ammonia-oxidizing microbes, affect the process of soil nitrogen (N) transformation, and gain a competitive advantage. However, the current researches on competition mechanism of Chromolaena odorata have not involved soil nitrogen transformation. In this study, we compared the microbially mediated soil transformations of invasive C.

Fulminant fatal pneumonia and bacteremia due to in an immunocompetent man: a case report and literature review.

Background: is associated with soft tissue infection, bacteremia and gastroenteritis. Involvement of respiratory system in adults is extremely rare. We report a case of fulminant pneumonia and bacteremia due to in a patient without underlying diseases.