Charge-transfer complexation of coordination cages for enhanced photochromism and photocatalysis.

Intensified host-guest electronic interplay within stable metal-organic cages (MOCs) presents great opportunities for applications in stimuli response and photocatalysis. Zr-MOCs represent a type of robust discrete hosts for such a design, but their host-guest chemistry in solution is hampered by the limited solubility. Here, by using pyridinium-derived cationic ligands with tetrakis(3,5-bis(trifluoromethyl)phenyl)borate (BAr) as solubilizing counteranions, we report the preparation of soluble Zr-MOCs of different shapes (1-4) that are otherwise inaccessible through a conventional method.

Extracellular PKM2 Preserves Cardiomyocytes and Reduces Cardiac Fibrosis During Myocardial Infarction.

Substantial loss of cardiomyocytes during heart attacks and onset of other cardiovascular diseases is a major cause of mortality. Preservation of cardiomyocytes during cardiac injury would be the most effective strategy to manage these diseases in clinic. However, there is no effective treatment strategy that is able to prevent cardiomyocyte loss.

Novel carbon dots with dual Modulatory effects on the bone marrow and spleen as a potential therapeutic candidate for treating spinal cord injury.

Spinal cord injury triggers leukocyte mobilization from the peripheral circulation to the injury site, exacerbating spinal cord damage. Simultaneously, bone marrow hematopoietic stem cells (HSCs) and splenic leukocytes rapidly mobilize to replenish the depleted peripheral blood leukocyte pool. However, current treatments for spinal cord injuries overlook interventions targeting peripheral immune organs and tissues, highlighting the need to develop novel drugs capable of effectively regulating peripheral immunity and treating spinal cord injuries.

Adipocyte-derived small extracellular vesicles exacerbate diabetic ischemic heart injury by promoting oxidative stress and mitochondrial-mediated cardiomyocyte apoptosis.

Background: Diabetes increases ischemic heart injury via incompletely understood mechanisms. We recently reported that diabetic adipocytes-derived small extracellular vesicles (sEV) exacerbate myocardial reperfusion (MI/R) injury by promoting cardiomyocyte apoptosis. Combining in vitro mechanistic investigation and in vivo proof-concept demonstration, we determined the underlying molecular mechanism responsible for diabetic sEV-induced cardiomyocyte apoptosis after MI/R.

Enhanced oxidative potential and SO heterogeneous oxidation on candle soot after photochemical aging: Influencing mechanisms of different irradiation wavelengths.

Photochemistry plays a significant role in the atmospheric aging processes of soot. However, the physicochemical properties and changes in environmental and health effects of soot particles from sacrificial sources after photochemical aging remain unclear. The reaction mechanisms of soot under different irradiation wavelengths require further investigation.

Device-related patient outcomes for coronary stents: A MAUDE database analysis.

The growing prevalence of coronary artery diseases in the US corresponds to the increasing use of minimally invasive techniques that require coronary stents. Although extensive research is available on the perioperative outcomes of the 3 stent options - bare-metal stents (BMS), drug-eluting stents (DES), and bioresorbable drug-eluting stents (BVS), a knowledge gap exists in the longitudinal monitoring of patient outcomes due to device-related causes. Therefore, our study examines the device-related patient outcome and the relative performance for BMS, DES, and BVS.

Circulating tumor cells are associated with lung cancer subtypes: a large-scale retrospective study.

Background: Circulating tumor cells (CTCs) provide a unique resource to decipher cell molecular properties of lung cancer. However, the clinicopathologic and radiological features associated with CTCs in different lung cancer subtypes remain poorly characterized. The aim of this study was to explore the clinicopathological and radiological features of CTCs in different lung cancer subtypes.

LncRNA MIAT binding to GATA3 activates MAPK signaling pathway and influences bronchopulmonary dysplasia.

Bronchopulmonary dysplasia (BPD) manifests in premature neonates with aberrant pulmonary function. Numerous long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of BPD. This study aims to elucidate the impact of the lncRNA myocardial infarction-associated transcript (MIAT) on the initiation and progression of BPD.

Artificial intelligence facial recognition of obstructive sleep apnea: a Bayesian meta-analysis.

Purpose: Conventional obstructive sleep apnea (OSA) diagnosis via polysomnography can be costly and inaccessible. Recent advances in artificial intelligence (AI) have enabled the use of craniofacial photographs to diagnose OSA. This meta-analysis aims to clarify the diagnostic accuracy of this innovative approach.

S100A1ct: A Synthetic Peptide Derived From S100A1 Protein Improves Cardiac Performance and Survival in Preclinical Heart Failure Models.

Background: The EF-hand Ca sensor protein S100A1 has been identified as a molecular regulator and enhancer of cardiac performance. The ability of S100A1 to recognize and modulate the activity of targets such as SERCA2a (sarcoplasmic reticulum Ca ATPase) and RyR2 (ryanodine receptor 2) in cardiomyocytes has mostly been ascribed to its hydrophobic C-terminal α-helix (residues 75-94). We hypothesized that a synthetic peptide consisting of residues 75 through 94 of S100A1 and an N-terminal solubilization tag (S100A1ct) could mimic the performance-enhancing effects of S100A1 and may be suitable as a peptide therapeutic to improve the function of diseased hearts.

Comparative analysis of differentially expressed genes and transcripts in the ovary of yak in estrus and anestrus.

Since most yaks have a long postpartum anestrus period, postpartum anestrus is the main factor affecting the reproductive efficiency of yaks. In this study, the third-generation sequencing technology was used to successfully screen differentially expressed genes (DEGs) and differentially expressed transcripts (DETs) in the ovarian tissues of yaks during estrus and anestrus. The functional references of DEGs and DETs were Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Clusters of Orthologous Genes database.

Tunable triple plasmon-induced transparency in E-type graphene metamaterials.

Enhancing light-matter interaction is crucial for boosting the performance of nanophotonic devices, which can be achieved via plasmon-induced transparency (PIT). This study introduces what we believe to be a novel E-type metamaterial structure crafted from a single graphene layer. The structure, comprising a longitudinal graphene ribbon and three horizontal graphene strips, leverages destructive interference at terahertz frequencies to manifest triple plasmon-induced transparency (triple-PIT).

Distributed parameter model of dynamic contrast-enhanced MRI in the identification of IDH mutation, 1p19q codeletion, and tumor cell proliferation in glioma patients.

Objectives: To investigate the clinical value of hemodynamic parameters derived from dynamic contrast-enhanced MRI (DCE-MRI) in predicting glioma genotypes including isocitrate dehydrogenase () mutation, codeletion status and the tumor proliferation index () noninvasively. And to compare the diagnostic performance of parameters of distributed parameter (DP)model and extended Tofts (Ex-Tofts) model.

Materials And Methods: Dynamic contrast-enhanced MRI (DCE-MRI) data of patients with glioma were prospectively enrolled from April 2021 to May 2023.

Medium and long-term regional water demand prediction using Harris hawks optimisation-backpropagation neural network model.

Precise water demand prediction is essential for the efficient allocation and rational utilisation of regional water resources. This study addressed the challenge associated with medium and long-term water demand prediction by introducing a novel coupled model, HHO-BPNN (Harris Hawks Optimisation-Backpropagation Neural Network). Principal component analysis was employed to reduce the dimensionality of potential water demand factors.

Autophagy is essential for somatic embryogenesis in citrus through regulating amyloplast degradation and lipid homeostasis.

Autophagy is a conserved degradation pathway that regulates the clearance of paternal substrate at the early embryogenesis stage of animals. However, its mode of action is likely different in plants, which can regenerate through apomixis without fertilisation. Somatic embryogenesis (SE) is a unique plant process widely used for plant propagation and germplasm utilisation.

Unveiling the Role of Strong Metal-Support Interactions in Gold-Catalyzed CO Oxidation on MnO Polymorphs.

The effectiveness of gold (Au)-based catalysts in CO oxidation is significantly influenced by strong metal-support interactions with surface oxygen structures, the mechanisms of which remain elusive. To investigate this property, we selected γ-MnO, featuring Mn(-O-)Mn and Mn-O-Mn structural motifs, and β-MnO, characterized by Mn-O-Mn linkages, as support materials. The CO oxidation process was investigated by fabricating Au nanoparticles supported on these two MnO polymorphs.

HIV/AIDS-related knowledge and attitudes toward people living with HIV among college students in Xuzhou, Jiangsu Province, China: a cross-sectional survey.

Background: In the contemporary landscape, college students have emerged as a demographic increasingly vulnerable to AIDS. Recognizing that heightened awareness and progressive attitudes toward HIV are pivotal in its prevention, this study was conceived with the intent to meticulously evaluate the level of HIV understanding amongst college students, gauge their sentiments toward people living with HIV (PLHIV), and scrutinize factors influencing these perceptions.

Method: This study used an anonymous online questionnaire to collect data through a cross-sectional survey.

Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration.

Timely and effective interventions after tracheal mucosal injury are lack in clinical practices, which elevate the risks of airway infection, tracheal cartilage deterioration, and even asphyxiated death. Herein, we proposed a biomaterial-based strategy for the repair of injured tracheal mucosal based on a copper hydrogen phosphate nanosheets (CuHP NSs) functionalized commercial hydrogel (polyethylene glycol disuccinimidyl succinate-human serum albumin, PH). Such CuHP/PH hydrogel achieved favorable injectability, stable gelation, and excellent adhesiveness within the tracheal lumen.

Experimental species removal reveals species contributions to positive pollinator-mediated reproductive interactions.

Pollinator-mediated reproductive interactions among co-flowering plant species provide a canonical example of how biotic factors may contribute to species coexistence, yet we lack understanding of the exact mechanisms. Flowering-dominant and unusually attractive "magnet species" with disproportionate contributions to pollination may play key roles in such reproductive interactions, but their relative roles within the same community have rarely been assessed. We experimentally removed either a flowering-dominant or a highly attractive magnet species and compared effects on visitation frequency, pollinator richness, and seed set of co-flowering plants.

Survival Outcomes of Neoadjuvant Therapy Followed by Sleeve Lobectomy in Non-Small Cell Lung Cancer.

Background: This study was carried out to evaluate the impact of neoadjuvant therapy on long-term survival of patients with non-small cell lung cancer undergoing sleeve lobectomy.

Methods: A total of 613 patients were retrospectively analyzed, including 124 who received neoadjuvant therapy. A 1:2 propensity score matching method was adopted to create a balanced cohort including 110 with neoadjuvant therapy and 169 without neoadjuvant therapy.

Revealing the intrinsic nature of Cu- and Ce-doped MnO catalysts with positive and negative effects on CO oxidation using DRIFTS-MS.

Aiming at the problem of the poor performance of an Mn-MOF-74-derived MnO catalyst in low-temperature carbon monoxide (CO) oxidation, copper (Cu) and cerium (Ce) elements were used to modify the MnO catalyst to improve its performance in low-temperature CO oxidation. According to the results of catalytic performance testing, the CO oxidation activity of the CuMnO catalyst was significantly improved compared with that of the pristine MnO catalyst, when a CO conversion rate of 90% was achieved at 118 °C. According to X-ray photoelectron spectroscopy and Brunauer-Emmett-Teller analyses, the (Mn + Mn)/(Mn + Mn + Mn) ratio and the O/O ratio increased after Cu doping, indicating promoted oxygen vacancy generation.

Associations of urinary nicotine metabolites and essential metals with metabolic syndrome in older adults: The mediation effect of insulin resistance.

Exposure to tobacco smoke and essential metals is linked with metabolic syndrome (MS). However, the joint effect of them on MS in older adults and the underlying mechanisms are still unclear. This large-scale study measured the urinary concentrations of 8 nicotine metabolites and 8 essential metals in 4564 older adults from Shenzhen, China.