[About the impact of the dendritic cell autovaccine on the results of treatment of non-small-cell lung cancer patients].

In thoracic department of the National Cancer Institute studied the effectiveness of dendritic cell autovaccine in the postoperative period in non-small-cell lung cancer patients. The results, showing good tolerance dendritic cell autovaccine. Shows the formation of the expressed antigen immune response after repeated injections dendritic cell autovaccine, as manifested after 4 revaccination.

Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial.

Background: Use of cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), has the potential to increase survival in patients with advanced non-small-cell lung cancer. We therefore compared chemotherapy plus cetuximab with chemotherapy alone in patients with advanced EGFR-positive non-small-cell lung cancer.

Methods: In a multinational, multicentre, open-label, phase III trial, chemotherapy-naive patients (>or=18 years) with advanced EGFR-expressing histologically or cytologically proven stage wet IIIB or stage IV non-small-cell lung cancer were randomly assigned in a 1:1 ratio to chemotherapy plus cetuximab or just chemotherapy.

Randomized phase III trial comparing single-agent paclitaxel Poliglumex (CT-2103, PPX) with single-agent gemcitabine or vinorelbine for the treatment of PS 2 patients with chemotherapy-naïve advanced non-small cell lung cancer.

Background: Patients with advanced non-small cell lung cancer (NSCLC) and impaired performance status (PS >or= 2) have limited life expectancies and decreased tolerance for drug-induced toxicities. Current treatment guidelines indicate that PS 2 patients benefit from systemic therapy. Further refinement of treatment in these patients requires reduction of treatment-associated toxicities while maintaining or improving efficacy.

[The use of copper sulfate in the treatment of esophageal cancer].

The authors have developed and approbated a methodology involving the use of copper sulphate as a radio sensitizer. The methods permit the enhancement of the immediate efficiency of treatment up to the level comparative with the best results of radiosensibilization at the expense of cytostatic agents. The incidence of complete regression of the tumor came up to 43.

[The application of combined antibacterial preparation Unazin for the prophylaxis of purulent postop complications at the clinic of thoracic oncology].

Antimicrobal preparation Unazin, combining sodium sulbactam and sodium ampicillin, characterized by broad antibacterial spectrum and potency to overcome the microorganisms stability, was applied in 15 patients in the early postoperative period after operations for pulmonary, esophageal, cardial cancers and mediastinal tumor. In these patients purulent-septic complications were not noted. According to the retrospective analysis data, of 846 patients, operated earlier, the complications have occurred in 131 (13.

[The puncture cytological diagnosis of neoplasms of the mediastinum (11 years of experience)].

Routinely stained cytological preparations of puncture biopsy specimens of mediastinal tumors from 870 patients are examined. Diagnostically informative material is investigated in 759 (87.3%) cases; malignant tumors are diagnosed in 538 (62%) cases, benign in 221 (25.

[Blood triboluminescence in patients with cancer of the proximal stomach and esophagus].

Total triboluminescence, i.e. optic radiation induced as a result of mechanic activation of venous blood in a TPA-2 triboluminometer, was measured in patients with cancer of the gastric cardia and esophagus, and in healthy subjects.

[A method for the combined treatment of cancer of the esophagus and cardia by using intensive preoperative gamma teletherapy and intracavity hyperthermia].

Local intracavitary hyperthermia and simultaneous intensive-concentrated irradiation were used in 23 patients with esophageal cancer and 64 cases of cardioesophageal malignancy prior to surgery. The procedure for thermometry is described. Hyperthermia was carried out after the second and fifth (out of six) radiation fractions, thermotolerability being taken into account.

[Prevention of postoperative complications in the surgical treatment of cancer of the lung, esophagus, stomach, large intestine and the rectum in patients over 60 years old].

The study including 414 patients aged over 60 years suffering lung esophageal, gastric and colorectal cancer was carried out to assess the possibility of preventing postoperative complications. Preoperative preparation, anesthesiologic medication and drug treatment in the early postoperative period included vitamins, eleutherococcus, sodium oxybutyrate, retabolil, splenin, curantyl, heparin, panangin, sulfalen and trichopol. In that group, the overall postoperative complication rate was 1.

[Questionnaire-based determination of groups at high risk for lung cancer].

The factor analysis of qualitative parameters carried out in 968 patients with lung cancer helped identify certain features which may play the key role in the development and, consequently, diagnosis of various types of the disease. In workers of major industries, smoking proved a significant factor of higher incidence of lung cancer. Formation of the habit at an earlier age, its intensity and concomitant occupational hazards were found to increase the risk of cancer, particularly, in males.

[The effect of age-related changes on the hypophyseo-adrenal and sympathetico-adrenal systems in patients with cancer of the digestive tract and lungs].

An analysis of the activity of pituitary-adrenal and sympathetic-adrenal systems in patients with cancer of the digestive canal and lungs with consideration of age, sex and stage of the disease indicates that not age but the development of the tumour process is the leading factor in disorders of the neuroendocrine homeostasis. Therapeutic measures are discussed.

[Choice of the method in the surgical treatment of cancer of the thoracic part of the esophagus].

The optimal approaches to the choice of the surgical treatment of carcinoma of the thoracic esophagus are discussed from analysis of 425 operations. Louis' operation providing for a convenient approach for a rather high resection of the esophagus with one-stage esophagogastric anastomosis is recommended in localization of the tumor in the inferior third of the esophagus. Garlock's operation is indicated only in low localization of the carcinoma (diaphragmatic and supradiaphragmatic segments).

[Radioimmunologic analysis of ferritin, carcinoembryonic antigen and prolactin for evaluating the prognosis and effectiveness of treating breast cancer].

The levels of tumor markers--CEA, ferritin and prolactin (the hormone of the anterior pituitary gland) were studied in the blood serum of 178 breast cancer patients in the menopause during combined therapy using a radioimmunoassay. This combination was shown to be informative for assessment of prognosis of disease and efficacy of antitumor therapy which was confirmed by clinical and x-ray findings and observation of a tumor process in breast cancer patients over a 5-year period.