Robust T estimation with balanced steady state free precession.

Purpose: To develop a novel signal representation for balanced steady state free precession (bSSFP) displaying its T independence on B and on magnetization transfer (MT) effects.

Methods: A signal model for bSSFP is developed that shows only an explicit dependence (up to a scaling factor) on E (and, therefore, T) and a novel parameter c (with implicit dependence on the flip angle and E). Moreover, it is shown that MT effects, entering the bSSFP signal via a binary spin bath model, can be captured by a redefinition of T and, therefore, leading to modification of E, resulting in the same signal model.

Simultaneous 18-FDG PET and MR imaging in lower extremity arterial disease.

Background: Simultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a novel hybrid imaging method integrating the advances of morphological tissue characterization of MRI with the pathophysiological insights of PET applications.

Aim: This study evaluated the use of simultaneous 18-FDG PET/MR imaging for characterizing atherosclerotic lesions in lower extremity arterial disease (LEAD).

Methods: Eight patients with symptomatic stenoses of the superficial femoral artery (SFA) under simultaneous acquisition of 18-FDG PET and contrast-enhanced MRI using an integrated whole-body PET/MRI scanner.

Getting the phase consistent: The importance of phase description in balanced steady-state free precession MRI of multi-compartment systems.

Purpose: Determine the correct mathematical phase description for balanced steady-state free precession (bSSFP) signals in multi-compartment systems.

Theory And Methods: Based on published bSSFP signal models, different phase descriptions can be formulated: one predicting the presence and the other predicting the absence of destructive interference effects in multi-compartment systems. Numerical simulations of bSSFP signals of water and acetone were performed to evaluate the predictions of these different phase descriptions.

Metabolic disturbances potentially attributable to clogging during continuous renal replacement therapy.

Background: Clogging is characterized by a progressive impairment of transmembrane patency in renal replacement devices and occurs due to obstruction of pores by unknown molecules. If citrate-based anti-coagulation is used, clogging can manifest as a metabolic alkalosis accompanied by hypernatremia and hypercalcemia, primarily a consequence of NaCitrate infusion. An increased incidence of clogging has been observed during the COVID-19 pandemic.

Older Adult Woman in a Coma After Acute Laryngitis.

A 72-year-old woman with a history of adenocarcinoma of the lung, for which she was receiving tyrosine kinase inhibitor therapy with osimertinib, was admitted to the ED because of clinical deterioration with extreme fatigue and fever. She was already receiving antibiotic therapy initiated by her general practitioner because of symptoms of an upper respiratory tract infection. She was febrile (38.

Is the internet a sufficient source of information on sarcoidosis?

Introduction: Many patients use the internet as a source of health information. Sarcoidosis is a complex disease, and internet resources have not yet been analyzed for reliability and content on sarcoidosis.

Aims: Our study aimed to investigate the content and the quality of information on sarcoidosis provided by internet resources.

[OCT, Triple H or anything else?].

Hyperammonemia is a life-threatening condition, the prognosis of which depends on a rapid reduction of ammonia. If a hepatic cause is excluded, the differential diagnosis is broad and even in adulthood includes hereditary metabolic diseases. Here, the case of a 25-year-old female patient with severe hyperammonemia refractory to standard therapy is described and the relevance of extracorporeal elimination of ammonia emphasized.

Indications and Outcomes of Patients Receiving Therapeutic Plasma Exchange under Critical Care Conditions: A Retrospective Eleven-Year Single-Center Study at a Tertiary Care Center.

Therapeutic plasma exchange (TPE) is frequently performed in critical care settings for heterogenous indications. However, specific intensive care unit (ICU) data regarding TPE indications, patient characteristics and technical details are sparse. : We performed a retrospective, single-center study using data from January 2010 until August 2021 for patients treated with TPE in an ICU setting at the University Hospital Zurich.

How Informed Are German Patients with Pulmonary Sarcoidosis about Their Disease?

Background: Sarcoidosis is a multisystemic disease with a heterogenous course of disease. Comprehensive information about the complexity and treatment indications is essential for improving patient knowledge and adhering to therapy.

Objectives: The aim of our study was to investigate the level and resources of information in patients with sarcoidosis and to analyze differences in patient subgroups including age and gender.

Approximate scaling of the SSFP steady state.

Purpose: It is shown that the steady state of rapid, TR-periodic steady-state free precession (SSFP) sequences at small to moderate flip angles exhibits a universal, approximate scaling law with respect to variations of . Implications for the accuracy and precision of relaxometry experiments are discussed.

Methods: The approximate scaling law is derived from and numerically tested against known analytical solutions.

Immunomodulatory treatment in unclassifiable interstitial lung disease: A retrospective study of treatment response.

Background And Objective: The optimal management of unclassifiable Interstitial lung disease (ILD) remains a challenge. The aim of this study was to describe pulmonary function trajectories for patients treated with immunomodulatory therapy and for untreated patients.

Methods: Clinical information and treatment data were obtained retrospectively at two ILD centres.

Outcomes of patients with acute respiratory failure on veno-venous extracorporeal membrane oxygenation requiring additional circulatory support by veno-venoarterial extracorporeal membrane oxygenation.

Objective: Veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) is increasingly used to support patients with severe acute respiratory distress syndrome (ARDS). In case of additional cardio-circulatory failure, some experienced centers upgrade the V-V ECMO with an additional arterial return cannula (termed V-VA ECMO). Here we analyzed short- and long-term outcome together with potential predictors of mortality.

Elimination of Herpes Simplex Virus-2 and Epstein-Barr Virus With Seraph 100 Microbind Affinity Blood Filter and Therapeutic Plasma Exchange: An Explorative Study in a Patient With Acute Liver Failure.

Unlabelled: Herpes simplex virus (HSV)-2 is a rare cause of hepatitis that can lead to acute liver failure (ALF) and often death. The earlier the initiation of acyclovir treatment the better the survival. With regard to ALF, controlled randomized data support the use of therapeutic plasma exchange (TPE) both as bridge to recovery or transplantation-possibly by modulating the systemic inflammatory response and by replacing coagulation factors.

Renal Tubular Acidosis in Pregnant Critically Ill COVID-19 Patients: A Secondary Analysis of a Prospective Cohort.

Background: Renal tubular acidosis (RTA) is an extremely rare cause of metabolic acidosis (10 in 100,000). RTA has been linked neither to pregnancy nor to severe coronavirus disease 2019 (COVID-19). The purpose of this study was to analyze the prevalence and clinical course of normal anion gap metabolic acidosis in critically ill pregnant COVID-19 patients and to compare them to an age-matched nonpregnant female patient cohort.

YouTube-videos for patient education in lymphangioleiomyomatosis?

Background: The Internet is commonly used by patients to acquire health information. To date, no studies have evaluated the quality of information available on YouTube regarding lymphangioleiomyomatosis (LAM). Our aim was to determine the quality and content of YouTube videos regarding LAM and to compare the information provided with current knowledge and guidelines about the disease.

Highly Deep-Blue Luminescent Twisted Diphenylamino Terphenyl Emitters by Bromine-Lithium Exchange Borylation-Suzuki Sequence.

Four novel intensively blue luminescent chromophores were readily synthesized by bromine-lithium exchange borylation-Suzuki (BLEBS) sequence in moderate to good yields. Their electronic properties were studied by absorption and emission spectroscopy and quantum chemical calculations revealing deep-blue emission in solution as well as in the solid state and upon embedding into a PMMA (polymethylmethacrylate) matrix with small FWHM (full width at half maximum) values and CIE y values smaller than 0.1.

Configuration space representation of MRI sequences.

Purpose: Local solutions provide little intuition about the contrast, generated by MRI sequences with unbalanced gradients. A configuration space representation of the spin density allows to formalize signal localization and thereby overcome these limitations.

Theory And Methods: The continuous configuration model (CCM) constitutes a Fourier integral decomposition of the spin density, such that intrinsic tissue properties are separated from accumulated effects due to gradients and/or bulk off-resonance.

Linear Carbene Pyridine Copper Complexes with Sterically Demanding ,'-Bis(trityl)imidazolylidene: Syntheses, Molecular Structures, and Photophysical Properties.

The sterically demanding carbene ITr ('-bis(triphenylmethyl)imidazolylidene) was used as a ligand for the preparation of luminescent copper(I) complexes of the type [(ITr)Cu(R-pyridine/R'-quinoline)]BF (R = H, 4-CN, 4-CHO, 2,6-NH, and R' = 8-Cl, 6-Me). The selective formation of linear, bis(coordinated) complexes was observed for a series of pyridine and quinoline derivatives. Only in the case of 4-cyanopyridine a one-dimensional coordination polymer was formed, in which the cyano group of the cyanopyridine ligand additionally binds to another Cu atom in a bridging manner, thus leading to a trigonal planar coordination environment.

Pure balanced steady-state free precession imaging (pure bSSFP).

Purpose: To show that for tissues the conspicuous asymmetries in the frequency response function of bSSFP can be mitigated by using a short enough TR.

Theory And Methods: Configuration theory indicates that bSSFP becomes apparently "pure" (i.e.

Complex B mapping with Carr-Purcell spin echoes and its application to electrical properties tomography.

Purpose: To present a new complex-valued B mapping method for electrical properties tomography using Carr-Purcell spin echoes.

Methods: A Carr-Purcell (CP) echo train generates pronounced flip-angle dependent oscillations that can be used to estimate the magnitude of B . To this end, a dictionary is used that takes into account the slice profile as well as T relaxation along the echo train.