Publications by authors named "Gantala Srilatha"
Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.
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- Oxidative stress is a significant factor in cancer development, particularly in breast cancer, and is linked to NADPH oxidase (NOX) and the CYBA gene, which has specific polymorphisms.
- A study was conducted comparing 300 breast cancer patients to 300 healthy controls, examining the association of CYBA gene SNPs (-930 A/G and 242 C/T) with oxidative stress as indicated by higher plasma MDA levels.
- Results indicated that certain haplotypes of CYBA polymorphisms increased the risk of breast cancer and were correlated with elevated oxidative stress, suggesting that these genetic variations may contribute to cancer development.
Collagenase-1 (-1607 1G/2G), Gelatinase-A (-1306 C/T), Stromelysin-1 (-1171 5A/6A) functional promoter polymorphisms in risk prediction of type 2 diabetic nephropathy.
Gene
October 2018
Type 2 Diabetic Nephropathy (DN) is a common multifactorial disorder. Degradation of glomerular basement membrane (GBM) by matrix metalloproteases (MMPs) is a key event in the progression of renal disease. A functional polymorphism at position -1607 1G/2G, -1306 C/T and -1171 5A/6A has been shown to alter the transcriptional activity of MMP-1, MMP-2, and MMP-3 respectively, and also associated with several diseases contributing to inter-individual differences in susceptibility to type 2 DN.
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- * Researchers genotyped specific SNPs in 300 breast cancer patients and 300 healthy controls, utilizing various statistical software for analysis to find significant associations between certain alleles and increased breast cancer susceptibility.
- * Findings indicated that specific MMP polymorphisms are associated with clinical characteristics like hormone receptor status and metastasis, suggesting that these genetic variations collectively increase breast cancer risk and may influence patient survival.
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- * The study analyzes polymorphisms in CASP8 and CASP3 genes among 300 CAD patients and 300 healthy controls, using genetic testing methods to identify variations linked to disease risk.
- * Findings indicate that certain genotypes of CASP8 and CASP3 are associated with an increased risk of CAD, suggesting these polymorphisms could serve as genetic markers for the disease.
Coronary artery disease (CAD) remains to be the prominent health problem in India, and its incidence is growing in developing countries as well. Matrix metalloproteinase 1 (MMP 1) is highly expressed in disruption-prone shoulder regions of the fibrous plaques. The present study aims to investigate association of MMP 1 gene polymorphisms (-1607 1G/2G) and serum circulating levels with CAD.
View Article and Find Full Text PDFAim: Atherosclerosis, the underlying pathology of cardiovascular disease, is a common, multifactorial disorder with both genetic and environmental components as risk factors. Gelatinase B, also known as MMP-9, is one of the matrix metalloproteinases that is highly expressed in the disruption-prone regions of atherosclerotic plaques. It has been hypothesized that a genetic variation affecting the expression or activity of MMP-9 influences the susceptibility and progression of atherosclerosis.
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