Effect of apple polyphenol concentrate on lipid metabolism in rats under experimental insulin resistance.

Introduction: Obesity is strongly associated with an increased risk of developing insulin resistance as the metabolic indicator of prediabetes and a major risk factor in diabetes mellitus type 2 pathogenesis. Medicinal products obtained from apples can be used as potent prophylactic and therapeutic remedies in treatment of diabetes mellitus.

Aim: Experiment was designed to study the effect of total apple polyphenol food concentrate on lipid metabolism under experimental IR.

Grape polyphenols increase the activity of HDL enzymes in old and obese rats.

HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from "Enoant" obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle.