MiR-652-3p promotes malignancy and metastasis of cancer cells via inhibiting TNRC6A in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) was one of the most prevalent life-threatening cancers. Metastasis is the leading cause of cancer-related death in HCC. MiRNAs play essential roles in cancer metastasis.

Itaconate prolongs the healthy lifespan by activating UPR in Caenorhabditis elegans.

Itaconate (ItA), a byproduct of the Krebs cycle, has recently emerged as an anti-inflammatory metabolite for inhibiting the overactive immune response. In addition to its immunomodulatory and antimicrobial effects, ItA may have other therapeutic avenues. Herein, the effect of ItA on aging was explored in order to better establish the therapeutic potential of this promising metabolite.

Metal ion induced-assembly of amylose in aqueous solution.

Cu(2+)/amylose assemblies of various sizes were prepared through the Cu(2+) ion induced-assembly of amylose. These assembly structures were characterized via transmission electronic microscopy (TEM), scanning electronic microscopy (SEM), dynamic light scattering (DLS), (1)H NMR analysis, fluorescence spectroscopy (FL) and UV-vis absorption spectroscopy (UV-vis). The results from these characterizations revealed the existence of a complexation effect and/or a bridging effect between the hydroxyl groups of amylose and Cu(2+) ions, and that the formation of the hydrophobic domains promoted the formation of Cu(2+)/amylose assemblies.