Publications by authors named "Gangrui He"
Article Synopsis
- Cerebral ischemic stroke is a major cause of neurological disability, and the lncRNA GAS5 is upregulated during such events, though its exact role in inflammation is unclear.
- Researchers used mouse models and cell cultures to study the interactions between GAS5, microRNA-9 (miR-9), and FOXO3, finding that GAS5 knockdown reduced stroke-related damage and inflammation.
- The study suggests that GAS5 can mitigate neuronal injury by competitively binding to miR-9, which in turn regulates the expression of FOXO3, offering new insights into potential therapeutic targets for ischemic stroke.
