Phosphodiesters quaternary ammonium nanoparticles as label-free light scattering probe for turn-off detection of tyrosine.

In this contribution, a new highly sensitive and selective sensor of the determination of tyrosine has been proposed based on the downturn effect of light scattering (LS) using phosphodiesters quaternary ammonium nanoparticles (PQANPs). Phosphodiesters quaternary ammonium (PQA), one of Gemini zwitterionic surfactants, self-aggregated into the micelle named as PQANPs, which generated strong LS signal in aqueous solution under the optimum condition. Interestingly, the powerful LS intensity of PQANPs with the maximum peak located at 391 nm significantly decreased after introducing trace amount of tyrosine.