Publications by authors named "Gangfeng Ren"
J Transl Med
October 2024
Article Synopsis
- In mouse models, knocking out the PLA2G2A gene reduces atherosclerotic plaque volume, but clinical trials with the sPLA2 inhibitor Varespladib haven’t effectively lowered cardiovascular risk, highlighting the need for further research on PLA2G2A's mechanisms.
- Using single-cell transcriptome data from carotid plaques with patient info, researchers found that PLA2G2A is mainly expressed in vascular fibroblasts and interacts significantly with macrophages, especially in early plaque stages related to inflammation.
- The study concludes that PLA2G2A promotes early plaque progression by activating macrophage-related pathways and suggests its serum levels could be valuable for diagnosing mild carotid artery stenosis.
